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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1969 Apr;62(4):1077–1084. doi: 10.1073/pnas.62.4.1077

COMPLEX MITOCHONDRIAL DNA IN LEUKEMIC AND NORMAL HUMAN MYELOID CELLS*

David A Clayton 1,2, Jerome Vinograd 1,2
PMCID: PMC223617  PMID: 5256408

Abstract

Mitochondrial DNA's from the peripheral blood of 14 patients with granulocytic leukemia contained a circular dimer form. No such structure could be found in M DNA's from three patients with nonmalignant proliferations of granulocytes. The frequency of the circular dimer form is reduced upon treatment with antileukemic drugs. The above results suggest that a significant relation exists between the formation and presence of the circular dimer M DNA form and granulocytic leukemia in man.

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Selected References

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  1. Attardi B., Attardi G. A membrane-associated RNA of cytoplasmic origin in HeLa cells. Proc Natl Acad Sci U S A. 1967 Sep;58(3):1051–1058. doi: 10.1073/pnas.58.3.1051. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Clayton D. A., Smith C. A., Jordan J. M., Teplitz M., Vinograd J. Occurrence of complex mitochondrial DNA in normal tissues. Nature. 1968 Dec 7;220(5171):976–979. doi: 10.1038/220976a0. [DOI] [PubMed] [Google Scholar]
  3. Clayton D. A., Vinograd J. Circular dimer and catenate forms of mitochondrial DNA in human leukaemic leucocytes. Nature. 1967 Nov 18;216(5116):652–657. doi: 10.1038/216652a0. [DOI] [PubMed] [Google Scholar]
  4. Goebel W., Helinski D. R. Generation of higher multiple circular DNA forms in bacteria. Proc Natl Acad Sci U S A. 1968 Dec;61(4):1406–1413. doi: 10.1073/pnas.61.4.1406. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Hickson F. T., Roth T. F., Helinski D. R. Circular DNA forms of a bacterial sex factor. Proc Natl Acad Sci U S A. 1967 Oct;58(4):1731–1738. doi: 10.1073/pnas.58.4.1731. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hudson B., Vinograd J. Catenated circular DNA molecules in HeLa cell mitochondria. Nature. 1967 Nov 18;216(5116):647–652. doi: 10.1038/216647a0. [DOI] [PubMed] [Google Scholar]
  7. NOWELL P. C., HUNGERFORD D. A. Chromosome studies in human leukemia. II. Chronic granulocytic leukemia. J Natl Cancer Inst. 1961 Nov;27:1013–1035. [PubMed] [Google Scholar]
  8. Pikó L., Blair D. G., Tyler A., Vinograd J. Cytoplasmic DNA in the unfertilized sea urchin egg: physical properties of circular mitochondrial DNA and the occurrence of catenated forms. Proc Natl Acad Sci U S A. 1968 Mar;59(3):838–845. doi: 10.1073/pnas.59.3.838. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Radloff R., Bauer W., Vinograd J. A dye-buoyant-density method for the detection and isolation of closed circular duplex DNA: the closed circular DNA in HeLa cells. Proc Natl Acad Sci U S A. 1967 May;57(5):1514–1521. doi: 10.1073/pnas.57.5.1514. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Roth T. F., Helinski D. R. Evidence for circular DNA forms of a bacterial plasmid. Proc Natl Acad Sci U S A. 1967 Aug;58(2):650–657. doi: 10.1073/pnas.58.2.650. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Rush M. G., Kleinschmidt A. K., Hellmann W., Warner R. C. Multiple-length rings in preparations of phi-X174 replicative form. Proc Natl Acad Sci U S A. 1967 Oct;58(4):1676–1683. doi: 10.1073/pnas.58.4.1676. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Rush M. G., Warner R. C. Multiple length rings of phi-X174 and S13 replicative forms. 3. A possible intermediate in recombination. J Biol Chem. 1968 Sep 25;243(18):4821–4826. [PubMed] [Google Scholar]
  13. Wallach D. F. Cellular membranes and tumor behavior: a new hypothesis. Proc Natl Acad Sci U S A. 1968 Nov;61(3):868–874. doi: 10.1073/pnas.61.3.868. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Woodward D. O., Munkres K. D. Alterations of a maternally inherited mitochondrial structural protein in respiratory-deficient strains of Neurospora. Proc Natl Acad Sci U S A. 1966 Apr;55(4):872–880. doi: 10.1073/pnas.55.4.872. [DOI] [PMC free article] [PubMed] [Google Scholar]

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