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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1969 Apr;62(4):1189–1194. doi: 10.1073/pnas.62.4.1189

GIANT NUCLEOPLASMIC RNA IN THE SWITCH-ON OF COMPENSATORY RENAL GROWTH*

Margherita Willems 1,2, Hana A Musilova 1,2, Ronald A Malt 1,2
PMCID: PMC223632  PMID: 5256415

Abstract

Heterogeneous RNA (HnRNA) (ca. 10S-70S) labeled for ten minutes with 3H-uridine was identified by polyacrylamide-gel electrophoresis in the nucleoplasm of kidney cells. In the region >28S several discretely migrating species were present. Ten minutes after the removal of one kidney, labeled HnRNA >28S (“giant” HnRNA) in the remaining kidney began to decrease, and by 60 minutes it had fallen drastically. The presence of labeled giant HnRNA during a pulse label after uninephrectomy and its disappearance after longer labeling suggest that the decrease is a consequence of faster processing. Accelerated processing of giant HnRNA is antecedent to the increased synthesis of renal cytoplasmic RNA that follows uninephrectomy.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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