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. 1969 Apr;62(4):1218–1225. doi: 10.1073/pnas.62.4.1218

THE INTERACTION OF RNA POLYMERASE WITH HISTONES*

Thomas C Spelsberg 1, Sharon Tankersley 1, Lubomir S Hnilica 1
PMCID: PMC223636  PMID: 5256418

Abstract

Arginine-rich histones (F3) interact with both the bacterial and mammalian RNA polymerase and inhibit the in vitro RNA synthesis to a much greater extent than when associated with the DNA template. The lysine-rich histones (F1) inhibit the RNA synthesis mainly through template inhibition. Neither histone fraction displayed such an interaction with DNA polymerase. The RNA polymerase-F3 histone interaction takes place at ionic strength equal to or greater than those occurring in living cells, suggesting a possible role of arginine-rich histones in the regulation of RNA synthesis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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