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. 1969 Mar;62(3):741–748. doi: 10.1073/pnas.62.3.741

RELEASE OF NEWLY SYNTHESIZED DOPAMINE FROM DOPAMINE-CONTAINING TERMINALS IN THE STRIATUM OF THE RAT*

M J Besson 1, A Cheramy 1, P Feltz 1,†, J Glowinski 1
PMCID: PMC223661  PMID: 4389748

Abstract

The extraneuronal spontaneous efflux of 3H-dopamine synthesized endogenously in dopamine terminals has been demonstrated in vitro, by collecting the 3H amine in superfusates of isolated striatum of the rat previously incubated with 3H-tyrosine. The 3H-dopamine newly synthesized appears to be preferentially released. Furthermore, amphetamine and a monoamine oxidase inhibitor (Carton) markedly increased the release of 3H-dopamine. This effect was also observed with substances normally contained in some striatal neurons: acetylcholine and 5-hydroxytryptamine.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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