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. 1969 Mar;62(3):756–763. doi: 10.1073/pnas.62.3.756

D-AMINO ACID OXIDASE IN LEUKOCYTES: A POSSIBLE D-AMINO-ACID-LINKED ANTIMICROBIAL SYSTEM*

Martin J Cline 1,2, Robert I Lehrer 1,2
PMCID: PMC223663  PMID: 4389749

Abstract

D-Amino acid oxidase has been identified within the granule fraction of human neutrophilic leukocytes. Leukocyte homogenates and purified kidney D-amino acid oxidase can utilize either isolated D-amino acids or some species of bacteria as substrates for the generation of hydrogen peroxide. When linked to leukocyte myeloperoxidase in vitro, purified D-amino acid oxidase constitutes a system lethal for certain bacteria. It is proposed that leukocyte D-amino acid oxidase and myeloperoxidase constitute a biochemically specific system for the recognition and killing of certain microorganisms.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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