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. 1969 Mar;62(3):793–799. doi: 10.1073/pnas.62.3.793

EVIDENCE FOR INTERGENIC COMPLEMENTATION IN HYBRID CELLS DERIVED FROM TWO HUMAN DIPLOID STRAINS EACH CARRYING AN X-LINKED MUTATION*

Marcello Siniscalco 1,2,3,†, Harold P Klinger 1,2,3,‡, Harry Eagle 1,2,3,§, Hilary Koprowski 1,2,3, Wilfred Y Fujimoto 1,2,3, J Edwin Seegmiller 1,2,3
PMCID: PMC223668  PMID: 5257005

Abstract

Two male diploid fibroblast strains, each carrying deficiency mutations at different X-linked loci (glucose-6-phosphate dehydrogenase and hypoxanthine-guanine-phosphoribosyltransferase) have been successfully hybridized. The resulting mononucleated hybrid cells have been shown to synthesize both normal gene products, indicating that both X chromosomes are functionally active in the hybrid cells. We believe this is the first reported example of intergenic complementation in fused human diploid cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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