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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1969 Mar;62(3):867–872. doi: 10.1073/pnas.62.3.867

CYTOCHROME OXIDASE DEFICIENCY IN WILSON'S DISEASE: A SUGGESTED CERULOPLASMIN FUNCTION*

M H K Shokeir 1, D C Shreffler 1
PMCID: PMC223678  PMID: 4308098

Abstract

The hypothesis is advanced that ceruloplasmin functions in enzymatic transfer of copper to copper-containing enzymes, such as cytochrome oxidase. To test this hypothesis, leucocytes from Wilson's disease patients, heterozygous carriers, and normal subjects were assayed for cytochrome-oxidase activity. The data reported here show markedly reduced levels of activity in Wilson's disease cases and moderate reductions in heterozygous individuals relative to normal controls. These observations and a close correlation between the level of cytochrome-oxidase activity in the leucocytes and ceruloplasmin in the serum tend to support the hypothesis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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