Abstract
To be effective, informatics tools for clinical trial protocols must inter-operate and share knowledge. We demonstrate a simple XML-based communication of eligibility criteria information between two independently-developed informatics tools. Using a shared DTD model of criteria, an authoring tool (developed within the Protégé environment) can send a list of eligibility criteria to a commercial system for automatic eligibility determination (the "iKnowChart" system by iKnowMed). The criteria model, developed as a Protégé ontology, includes both the terminology and the logic needed to compute eligibility for a given patient. As a demonstration of cross-tool communication, we have encoded criteria from an active clinical trial protocol (E1199), and shown how use of the authoring tool can effectively update the eligibility knowledge and the behavior of the commercial iKnowChart system. As part of the cross-tool knowledge sharing, we use Common Data Elements, an oncology terminology developed by the National Cancer Institute.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Ohno-Machado L., Gennari J. H., Murphy S. N., Jain N. L., Tu S. W., Oliver D. E., Pattison-Gordon E., Greenes R. A., Shortliffe E. H., Barnett G. O. The guideline interchange format: a model for representing guidelines. J Am Med Inform Assoc. 1998 Jul-Aug;5(4):357–372. doi: 10.1136/jamia.1998.0050357. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Peleg M., Boxwala A. A., Ogunyemi O., Zeng Q., Tu S., Lacson R., Bernstam E., Ash N., Mork P., Ohno-Machado L. GLIF3: the evolution of a guideline representation format. Proc AMIA Symp. 2000:645–649. [PMC free article] [PubMed] [Google Scholar]
- Rubin D. L., Gennari J. H., Srinivas S., Yuen A., Kaizer H., Musen M. A., Silva J. S. Tool support for authoring eligibility criteria for cancer trials. Proc AMIA Symp. 1999:369–373. [PMC free article] [PubMed] [Google Scholar]
- Schadow G., Russler D. C., Mead C. N., McDonald C. J. Integrating medical information and knowledge in the HL7 RIM. Proc AMIA Symp. 2000:764–768. [PMC free article] [PubMed] [Google Scholar]
- Sim I., Owens D. K., Lavori P. W., Rennels G. D. Electronic trial banks: a complementary method for reporting randomized trials. Med Decis Making. 2000 Oct-Dec;20(4):440–450. doi: 10.1177/0272989X0002000408. [DOI] [PubMed] [Google Scholar]
- Tu S. W., Kemper C. A., Lane N. M., Carlson R. W., Musen M. A. A methodology for determining patients' eligibility for clinical trials. Methods Inf Med. 1993 Aug;32(4):317–325. [PubMed] [Google Scholar]
- Wyatt J. C., Altman D. G., Heathfield H. A., Pantin C. F. Development of Design-a-Trial, a knowledge-based critiquing system for authors of clinical trial protocols. Comput Methods Programs Biomed. 1994 Jun;43(3-4):283–291. doi: 10.1016/0169-2607(94)90081-7. [DOI] [PubMed] [Google Scholar]