Skip to main content
PMC home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1966 Jun;55(6):1511–1517. doi: 10.1073/pnas.55.6.1511

Reactions of quinine, chloroquine, and quinacrine with DNA and their effects on the DNA and RNA polymerase reactions.

R L O'Brien, J G Olenick, F E Hahn
PMCID: PMC224352  PMID: 5336287

Full text

PDF
1511

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allison J. L., O'Brien R. L., Hahn F. E. DNA: reaction with chloroquine. Science. 1965 Sep 3;149(3688):1111–1113. doi: 10.1126/science.149.3688.1111. [DOI] [PubMed] [Google Scholar]
  2. BILLEN D. On the nature of a deoxynucleotide polymerase-deoxyribonucleic acid complex. Biochim Biophys Acta. 1963 Mar 26;68:342–353. doi: 10.1016/0006-3002(63)90156-2. [DOI] [PubMed] [Google Scholar]
  3. CAIRNS J. The bacterial chromosome and its manner of replication as seen by autoradiography. J Mol Biol. 1963 Mar;6:208–213. doi: 10.1016/s0022-2836(63)80070-4. [DOI] [PubMed] [Google Scholar]
  4. CHAMBERLIN M., BERG P. Deoxyribo ucleic acid-directed synthesis of ribonucleic acid by an enzyme from Escherichia coli. Proc Natl Acad Sci U S A. 1962 Jan 15;48:81–94. doi: 10.1073/pnas.48.1.81. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. COHEN S. N., YIELDING K. L. SPECTROPHOTOMETRIC STUDIES OF THE INTERACTION OF CHLOROQUINE WITH DEOXYRIBONUCLEIC ACID. J Biol Chem. 1965 Jul;240:3123–3131. [PubMed] [Google Scholar]
  6. Ciak J., Hahn F. E. Chloroquine: mode of action. Science. 1966 Jan 21;151(3708):347–349. doi: 10.1126/science.151.3708.347. [DOI] [PubMed] [Google Scholar]
  7. Cohen S. N., Yielding K. L. Inhibition of DNA and RNA polymerase reactions by chloroquine. Proc Natl Acad Sci U S A. 1965 Aug;54(2):521–527. doi: 10.1073/pnas.54.2.521. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. GOLDBERG I. H., RABINOWITZ M., REICH E. Basis of actinomycin action. I. DNA binding and inhibition of RNA-polymerase synthetic reactions by actinomycin. Proc Natl Acad Sci U S A. 1962 Dec 15;48:2094–2101. doi: 10.1073/pnas.48.12.2094. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. HASELKORN R. ACTINOMYCIN D AS A PROBE FOR NUCLEIC ACID SECONDARY STRUCTURE. Science. 1964 Feb 14;143(3607):682–684. doi: 10.1126/science.143.3607.682. [DOI] [PubMed] [Google Scholar]
  10. HURWITZ J., FURTH J. J., MALAMY M., ALEXANDER M. The role of deoxyribonucleic acid in ribonucleic acid synthesis. III. The inhibition of the enzymatic synthesis of ribonucleic acid and deoxyribonucleic acid by actinomycin D and proflavin. Proc Natl Acad Sci U S A. 1962 Jul 15;48:1222–1230. doi: 10.1073/pnas.48.7.1222. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Johnson H. G., Bach M. K. Apparent suppression of mutation rates in bacteria by spermine. Nature. 1965 Oct 23;208(5008):408–409. doi: 10.1038/208408a0. [DOI] [PubMed] [Google Scholar]
  12. KRAKOW J. S. RIBONUCLEIC ACID POLYMERASE OF AZOTOBACTER VINELANDII. III. EFFECT OF POLYAMINES. Biochim Biophys Acta. 1963 Aug 20;72:566–571. [PubMed] [Google Scholar]
  13. KURNICK N. B., RADCLIFFE I. E. Reaction between DNA and quinacrine and other antimalarials. J Lab Clin Med. 1962 Oct;60:669–688. [PubMed] [Google Scholar]
  14. LERMAN L. S. The structure of the DNA-acridine complex. Proc Natl Acad Sci U S A. 1963 Jan 15;49:94–102. doi: 10.1073/pnas.49.1.94. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. PARKER F. S., IRVIN J. L. The interaction of chloroquine with nucleic acids and nucleoproteins. J Biol Chem. 1952 Dec;199(2):897–909. [PubMed] [Google Scholar]
  16. PRICER W. E., Jr, WEISSBACH A. THE EFFECT OF LYSOGENIC INDUCTION WITH MITOMYCIN C ON THE DEOXYRIBONUCLEIC ACID POLYMERASE OF ESCHERICHIA COLI K12-LAMBDA. J Biol Chem. 1964 Aug;239:2607–2612. [PubMed] [Google Scholar]
  17. Pricer W. E., Jr, Weissbach A. The effect of lysogenic induction with mitomycin C on the DNA and DNA polymerase of Escherichia coli K12-mu. Biochem Biophys Res Commun. 1964;14:91–95. doi: 10.1016/0006-291x(63)90217-1. [DOI] [PubMed] [Google Scholar]
  18. REICH E. ACTINOMYCIN: CORRELATION OF STRUCTURE AND FUNCTION OF ITS COMPLEXES WITH PURINES AND DNA. Science. 1964 Feb 14;143(3607):684–689. doi: 10.1126/science.143.3607.684. [DOI] [PubMed] [Google Scholar]
  19. SCHELLENBERG K. A., COATNEY G. R. The influence of antimalarial drugs on nucleic acid synthesis in Plasmodium gallinaceum and Plasmodium berghei. Biochem Pharmacol. 1961 May;6:143–152. doi: 10.1016/0006-2952(61)90158-7. [DOI] [PubMed] [Google Scholar]
  20. SEVAG M. G., ASHTON B. EVOLUTION AND PREVENTION OF DRUG-RESISTANCE. Nature. 1964 Sep 26;203:1323–1326. doi: 10.1038/2031323a0. [DOI] [PubMed] [Google Scholar]
  21. STOLLAR D., LEVINE L. Antibodies to denatured deoxyribonucleic acid in lupus erythematosus serum. V. Mechanism of DNA-anti-DNA inhibition by chloroquine. Arch Biochem Biophys. 1963 May;101:335–341. doi: 10.1016/s0003-9861(63)80021-1. [DOI] [PubMed] [Google Scholar]
  22. TABOR H. The protective effect of spermine and other polyamines against heat denaturation of deoxyribonucleic acid. Biochemistry. 1962 May 25;1:496–501. doi: 10.1021/bi00909a021. [DOI] [PubMed] [Google Scholar]
  23. WATSON J. D., CRICK F. H. The structure of DNA. Cold Spring Harb Symp Quant Biol. 1953;18:123–131. doi: 10.1101/sqb.1953.018.01.020. [DOI] [PubMed] [Google Scholar]
  24. Ward D. C., Reich E., Goldberg I. H. Base specificity in the interaction of polynucleotides with antibiotic drugs. Science. 1965 Sep 10;149(3689):1259–1263. doi: 10.1126/science.149.3689.1259. [DOI] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES