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Proceedings of the AMIA Symposium logoLink to Proceedings of the AMIA Symposium
. 2000:903–907.

Text-based discovery in biomedicine: the architecture of the DAD-system.

M Weeber 1, H Klein 1, A R Aronson 1, J G Mork 1, L T de Jong-van den Berg 1, R Vos 1
PMCID: PMC2243779  PMID: 11080015

Abstract

Current scientific research takes place in highly specialized contexts with poor communication between disciplines as a likely consequence. Knowledge from one discipline may be useful for the other without researchers knowing it. As scientific publications are a condensation of this knowledge, literature-based discovery tools may help the individual scientist to explore new useful domains. We report on the development of the DAD-system, a concept-based Natural Language Processing system for PubMed citations that provides the biomedical researcher such a tool. We describe the general architecture and illustrate its operation by a simulation of a well-known text-based discovery: The favorable effects of fish oil on patients suffering from Raynaud's disease [1].

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aronson A. R., Rindflesch T. C. Query expansion using the UMLS Metathesaurus. Proc AMIA Annu Fall Symp. 1997:485–489. [PMC free article] [PubMed] [Google Scholar]
  2. Aronson A. R. The effect of textual variation on concept based information retrieval. Proc AMIA Annu Fall Symp. 1996:373–377. [PMC free article] [PubMed] [Google Scholar]
  3. Ribstein J., Halimi J. M., du Cailar G., Mimran A. Renal characteristics and effect of angiotensin suppression in oral contraceptive users. Hypertension. 1999 Jan;33(1):90–95. doi: 10.1161/01.hyp.33.1.90. [DOI] [PubMed] [Google Scholar]
  4. Rikken F., Vos R. How adverse drug reactions can play a role in innovative drug research. Pharm World Sci. 1995 Nov 24;17(6):195–200. doi: 10.1007/BF01870611. [DOI] [PubMed] [Google Scholar]
  5. Rindflesch T. C., Aronson A. R. Ambiguity resolution while mapping free text to the UMLS Metathesaurus. Proc Annu Symp Comput Appl Med Care. 1994:240–244. [PMC free article] [PubMed] [Google Scholar]
  6. Smalheiser N. R., Swanson D. R. Calcium-independent phospholipase A2 and schizophrenia. Arch Gen Psychiatry. 1998 Aug;55(8):752–753. doi: 10.1001/archpsyc.55.8.752. [DOI] [PubMed] [Google Scholar]
  7. Smalheiser N. R., Swanson D. R. Indomethacin and Alzheimer's disease. Neurology. 1996 Feb;46(2):583–583. doi: 10.1212/wnl.46.2.583. [DOI] [PubMed] [Google Scholar]
  8. Swanson D. R. Fish oil, Raynaud's syndrome, and undiscovered public knowledge. Perspect Biol Med. 1986 Autumn;30(1):7–18. doi: 10.1353/pbm.1986.0087. [DOI] [PubMed] [Google Scholar]
  9. Swanson D. R. Migraine and magnesium: eleven neglected connections. Perspect Biol Med. 1988 Summer;31(4):526–557. doi: 10.1353/pbm.1988.0009. [DOI] [PubMed] [Google Scholar]
  10. Swanson D. R. Somatomedin C and arginine: implicit connections between mutually isolated literatures. Perspect Biol Med. 1990 Winter;33(2):157–186. doi: 10.1353/pbm.1990.0031. [DOI] [PubMed] [Google Scholar]

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