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. 1988 May;57(5):451–454. doi: 10.1038/bjc.1988.105

Vascular function and the probability of skin necrosis after photodynamic therapy: an experimental study.

K Benstead 1, J V Moore 1
PMCID: PMC2246401  PMID: 3395550

Abstract

The clearance of an intradermally-injected solution of 133Xenon in 0.9% saline has been used to study the impairment and recovery of blood flow in mouse tail for 5 days following photodynamic therapy (PDT) with 2mg TPPS i.v. per mouse and a range of doses of white light. Impairment of blood flow was observed within 10 min of light exposure. Blood flow increased between day 1 and day 5 at light doses less than 151J cm-2 and had returned to control levels by day 5 at light doses less than 129J cm-2. In mice treated with a light dose that caused a 50% incidence of necrosis, there was no significant difference in the initial xenon clearance half-time (measured at 10 min and 1 day after PDT) between those mice which developed tail necrosis and those which healed. However, the latter showed significantly greater improvement in vascular function on days 2, 3 and 4. This suggests that the timing and extent of recovery of blood flow determined the risk of necrosis in individual mice.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barr H., Tralau C. J., MacRobert A. J., Krasner N., Boulos P. B., Clark C. G., Bown S. G. Photodynamic therapy in the normal rat colon with phthalocyanine sensitisation. Br J Cancer. 1987 Aug;56(2):111–118. doi: 10.1038/bjc.1987.166. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Berenbaum M. C., Hall G. W., Hoyes A. D. Cerebral photosensitisation by haematoporphyrin derivative. Evidence for an endothelial site of action. Br J Cancer. 1986 Jan;53(1):81–89. doi: 10.1038/bjc.1986.12. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bugelski P. J., Porter C. W., Dougherty T. J. Autoradiographic distribution of hematoporphyrin derivative in normal and tumor tissue of the mouse. Cancer Res. 1981 Nov;41(11 Pt 1):4606–4612. [PubMed] [Google Scholar]
  4. Chaudhuri K., Goldblatt P. J., Kreimer-Birnbaum M., Keck R. W., Selman S. H. Histological study of the effect of hematoporphyrin derivative photodynamic therapy on the rat jejunum. Cancer Res. 1986 Jun;46(6):2950–2953. [PubMed] [Google Scholar]
  5. Dougherty T. J., Gomer C. J., Weishaupt K. R. Energetics and efficiency of photoinactivation of murine tumor cells containing hematoporphyrin. Cancer Res. 1976 Jul;36(7 Pt 1):2330–2333. [PubMed] [Google Scholar]
  6. Dougherty T. J. Photoradiation therapy for cutaneous and subcutaneous malignancies. J Invest Dermatol. 1981 Jul;77(1):122–124. doi: 10.1111/1523-1747.ep12479341. [DOI] [PubMed] [Google Scholar]
  7. Gilbert C. W. Computer programmes for fitting Puck and probit survival curves. Int J Radiat Biol Relat Stud Phys Chem Med. 1969;16(4):323–332. doi: 10.1080/09553006914551351. [DOI] [PubMed] [Google Scholar]
  8. KETY S. S. Measurement of regional circulation by the local clearance of radioactive sodium. Am Heart J. 1949 Sep;38(3):321–328. doi: 10.1016/0002-8703(49)90845-5. [DOI] [PubMed] [Google Scholar]
  9. Kaye A. H., Morstyn G. Photoradiation therapy causing selective tumor kill in a rat glioma model. Neurosurgery. 1987 Mar;20(3):408–415. doi: 10.1227/00006123-198703000-00009. [DOI] [PubMed] [Google Scholar]
  10. Kessel D., Thompson P., Saatio K., Nantwi K. D. Tumor localization and photosensitization by sulfonated derivatives of tetraphenylporphine. Photochem Photobiol. 1987 Jun;45(6):787–790. doi: 10.1111/j.1751-1097.1987.tb07883.x. [DOI] [PubMed] [Google Scholar]
  11. Lim H. W., Young L., Hagan M., Gigli I. Delayed phase of hematoporphyrin-induced phototoxicity: modulation by complement, leukocytes, and antihistamines. J Invest Dermatol. 1985 Feb;84(2):114–117. doi: 10.1111/1523-1747.ep12275345. [DOI] [PubMed] [Google Scholar]
  12. Moore J. V., Keene J. P., Land E. J. Dose-response relationships for photodynamic injury to murine skin. Br J Radiol. 1986 Mar;59(699):257–261. doi: 10.1259/0007-1285-59-699-257. [DOI] [PubMed] [Google Scholar]
  13. Moore J. V. Necrosis of murine tail skin following photodynamic treatment with meso-tetra-(p-sulphophenyl) porphine (TPPS). Photochem Photobiol. 1987 Jun;45(6):791–794. doi: 10.1111/j.1751-1097.1987.tb07884.x. [DOI] [PubMed] [Google Scholar]
  14. Selman S. H., Kreimer-Birnbaum M., Goldblatt P. J., Anderson T. S., Keck R. W., Britton S. L. Jejunal blood flow after exposure to light in rats injected with hematoporphyrin derivative. Cancer Res. 1985 Dec;45(12 Pt 1):6425–6427. [PubMed] [Google Scholar]
  15. Selman S. H., Kreimer-Birnbaum M., Keck R. W., Milligan A. J., Goldblatt P. J., Britton S. Correlation of tumor blood flow to tumor regression after hematoporphyrin derivative (HPD) photodynamic therapy to transplantable bladder tumors. Adv Exp Med Biol. 1985;193:97–103. doi: 10.1007/978-1-4613-2165-1_11. [DOI] [PubMed] [Google Scholar]
  16. Zhou C. N., Yang W. Z., Ding Z. X., Wang Y. X., Shen H., Fan X. J., Ha X. W. The biological effects of photodynamic therapy on normal skin in mice--II. An electron microscopic study. Adv Exp Med Biol. 1985;193:111–115. doi: 10.1007/978-1-4613-2165-1_13. [DOI] [PubMed] [Google Scholar]
  17. de Ruiter J., van Putten L. M. Measurement of blood flow in mouse tail after irradiation. Radiat Res. 1975 Mar;61(3):427–438. [PubMed] [Google Scholar]

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