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. 1988 Feb;57(2):178–181. doi: 10.1038/bjc.1988.37

Carcinoma of the cervix uteri: an assessment of tumour proliferation using the monoclonal antibody Ki67.

D C Brown 1, D Cole 1, K C Gatter 1, D Y Mason 1
PMCID: PMC2246434  PMID: 3282535

Abstract

Thirty-one cervical biopsies of invasive carcinoma have been studied by immunohistochemical means using the monoclonal antibody Ki67 to determine tumour cell proliferation rates. A wide range (10-50%) in the extent of Ki67 staining (expressed as the percentage of labelled tumour cells) was observed indicating considerable variation on tumour growth rates. There was no significant relationship between the percentage of positive cells and conventional histological parameters such as cell type or tumour differentiation. Immunostaining with monoclonal antibody Ki67 therefore provides a new approach to the assessment of cervical tumour biopsies which will require long term clinical follow-up to establish its prognostic significance.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barnard N. J., Hall P. A., Lemoine N. R., Kadar N. Proliferative index in breast carcinoma determined in situ by Ki67 immunostaining and its relationship to clinical and pathological variables. J Pathol. 1987 Aug;152(4):287–295. doi: 10.1002/path.1711520407. [DOI] [PubMed] [Google Scholar]
  2. Bobrow L. G., Makin C. A., Law S., Bodmer W. F. Expression of low molecular weight cytokeratin proteins in cervical neoplasia. J Pathol. 1986 Feb;148(2):135–140. doi: 10.1002/path.1711480203. [DOI] [PubMed] [Google Scholar]
  3. Breur K. Growth rate and radiosensitivity of human tumours. I. Growth rate of human tumours. Eur J Cancer. 1966 Jun;2(2):157–171. doi: 10.1016/0014-2964(66)90008-9. [DOI] [PubMed] [Google Scholar]
  4. Cordell J. L., Falini B., Erber W. N., Ghosh A. K., Abdulaziz Z., MacDonald S., Pulford K. A., Stein H., Mason D. Y. Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes). J Histochem Cytochem. 1984 Feb;32(2):219–229. doi: 10.1177/32.2.6198355. [DOI] [PubMed] [Google Scholar]
  5. Crissman J. D., Makuch R., Budhraja M. Histopathologic grading of squamous cell carcinoma of the uterine cervix. An evaluation of 70 stage Ib patients. Cancer. 1985 Apr 1;55(7):1590–1596. doi: 10.1002/1097-0142(19850401)55:7<1590::aid-cncr2820550730>3.0.co;2-o. [DOI] [PubMed] [Google Scholar]
  6. Crocker J., Nar P. Nucleolar organizer regions in lymphomas. J Pathol. 1987 Feb;151(2):111–118. doi: 10.1002/path.1711510203. [DOI] [PubMed] [Google Scholar]
  7. Crocker J., Skilbeck N. Nucleolar organiser region associated proteins in cutaneous melanotic lesions: a quantitative study. J Clin Pathol. 1987 Aug;40(8):885–889. doi: 10.1136/jcp.40.8.885. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Fray R. E., Husain O. A., To A. C., Watts K. C., Lader S., Rogers G. T., Taylor-Papadimitriou J., Morris N. F. The value of immunohistochemical markers in the diagnosis of cervical neoplasia. Br J Obstet Gynaecol. 1984 Oct;91(10):1037–1041. doi: 10.1111/j.1471-0528.1984.tb03684.x. [DOI] [PubMed] [Google Scholar]
  9. Gatter K. C., Dunnill M. S., Gerdes J., Stein H., Mason D. Y. New approach to assessing lung tumours in man. J Clin Pathol. 1986 Jun;39(6):590–593. doi: 10.1136/jcp.39.6.590. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Gerdes J., Dallenbach F., Lennert K., Lemke H., Stein H. Growth fractions in malignant non-Hodgkin's lymphomas (NHL) as determined in situ with the monoclonal antibody Ki-67. Hematol Oncol. 1984 Oct-Dec;2(4):365–371. doi: 10.1002/hon.2900020406. [DOI] [PubMed] [Google Scholar]
  11. Gerdes J., Lelle R. J., Pickartz H., Heidenreich W., Schwarting R., Kurtsiefer L., Stauch G., Stein H. Growth fractions in breast cancers determined in situ with monoclonal antibody Ki-67. J Clin Pathol. 1986 Sep;39(9):977–980. doi: 10.1136/jcp.39.9.977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Gerdes J., Lemke H., Baisch H., Wacker H. H., Schwab U., Stein H. Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol. 1984 Oct;133(4):1710–1715. [PubMed] [Google Scholar]
  13. Goellner J. R. Carcinoma of the cervix. Clinicopathologic correlation of 196 cases. Am J Clin Pathol. 1976 Nov;66(5):775–785. doi: 10.1093/ajcp/66.5.775. [DOI] [PubMed] [Google Scholar]
  14. Macgregor J. E. Rapid onset cancer of the cervix. Br Med J (Clin Res Ed) 1982 Feb 13;284(6314):441–442. doi: 10.1136/bmj.284.6314.441. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Meyer J. S., Bauer W. C., Rao B. R. Subpopulations of breast carcinoma defined by S-phase fraction, morphology, and estrogen receptor content. Lab Invest. 1978 Sep;39(3):225–235. [PubMed] [Google Scholar]
  16. Prioleau P. G., Santa Cruz D. J., Meyer J. S., Bauer W. C. Verrucous carcinoma: a light and electron microscopic, autoradiographic, and immunofluorescence study. Cancer. 1980 Jun 1;45(11):2849–2857. doi: 10.1002/1097-0142(19800601)45:11<2849::aid-cncr2820451122>3.0.co;2-s. [DOI] [PubMed] [Google Scholar]
  17. REAGAN J. W., HAMONIC M. J., WENTZ W. B. Analytical study of the cells in cervical squamous-cell cancer. Lab Invest. 1957 May-Jun;6(3):241–250. [PubMed] [Google Scholar]
  18. Richart R. M., Barron B. A. A follow-up study of patients with cervical dysplasia. Am J Obstet Gynecol. 1969 Oct 1;105(3):386–393. doi: 10.1016/0002-9378(69)90268-3. [DOI] [PubMed] [Google Scholar]
  19. Straus M. J., Moran R. E. The cell cycle kinetics of human breast cancer. Cancer. 1980 Dec 15;46(12):2634–2639. doi: 10.1002/1097-0142(19801215)46:12<2634::aid-cncr2820461217>3.0.co;2-k. [DOI] [PubMed] [Google Scholar]
  20. Van Nagell J. R., Jr, Donaldson E. S., Wood E. G., Maruyama Y., Utley J. Small cell cancer of the uterine cervix. Cancer. 1977 Nov;40(5):2243–2249. doi: 10.1002/1097-0142(197711)40:5<2243::aid-cncr2820400534>3.0.co;2-h. [DOI] [PubMed] [Google Scholar]
  21. Wells M., Brown L. J., Jackson P. Low molecular weight cytokeratin proteins in cervical neoplasia. J Pathol. 1986 Sep;150(1):69–71. doi: 10.1002/path.1711500112. [DOI] [PubMed] [Google Scholar]

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