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. 1988 Jun;57(6):587–590. doi: 10.1038/bjc.1988.133

Human angiogenin, an organogenic protein.

J F Riordan 1, B L Vallee 1
PMCID: PMC2246469  PMID: 2457389

Abstract

Angiogenin is a 14 kD protein, initially isolated as a tumour-cell secreted product but subsequently found to be a normal constituent of human plasma. It is a potent inducer of blood vessel formation on the chorioallantoic membrane of the chick embryo. Chemical characterization of the protein reveals a remarkable homology to the pancreatic ribonuclease family and has led to the identification of a unique ribonucleolytic activity for angiogenin. It is a particularly potent inhibitor of in vitro protein synthesis. Treatment with placental ribonuclease inhibitor abolishes the biological and enzymatic activities of angiogenin, an effect with important mechanistic, physiological and pharmacologic implications.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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