Abstract
Following the recent identification of gastric parietal cell carcinoma (Capella et al., 1984), a histological and clinical review of 125 consecutive cases of gastric cancers treated surgically during a 9-year period was undertaken. The pathology was reviewed blind and in addition to H & E sections, staining with Luxol Fast Blue, phosphotungstic acid haematoxylin and E-M studies were performed to identify parietal cell differentiation. The surgical procedures performed were curative R2 gastrectomy (n = 56), palliative resection (n = 30), gastro-enterostomy (n = 25) and intubation (n = 14). The 30-day operative mortality was 12/125 (10%) overall and 4/56 (7%) in the curative resection group. Two parietal cell cancers were identified and a further 4 tumours showed areas of parietal cell differentiation. All occurred in male patients (mean age 55 years, range 43-62). Sixteen patients out of the 56 patients (29%) who underwent curative R2 resection have survived long-term (mean 5.5 years, range 2.5-11): 4/5 mucosal/submucosal cancers (T1N0), 5/29 intestinal cancers (T2N0-2) 2/16 diffuse cancers (T2N1) and 5/6 with parietal cell cancer/differentiation (T2-3N0-2). There were no survivors beyond 14 months in the patients who were treated by palliative resection, bypass or intubation irrespective of histology. This study suggests that gastric parietal cell carcinoma carries a good prognosis after curative resection despite the advanced stage at presentation.
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- AZZOPARDI J. G., POLLOCK D. J. ARGENTAFFIN AND ARGYROPHIL CELLS IN GASTRIC CARCINOMA. J Pathol Bacteriol. 1963 Oct;86:443–451. doi: 10.1002/path.1700860219. [DOI] [PubMed] [Google Scholar]
- Capella C., Frigerio B., Cornaggia M., Solcia E., Pinzon-Trujillo Y., Chejfec G. Gastric parietal cell carcinoma--a newly recognized entity: light microscopic and ultrastructural features. Histopathology. 1984 Sep;8(5):813–824. doi: 10.1111/j.1365-2559.1984.tb02397.x. [DOI] [PubMed] [Google Scholar]
- Cuschieri A. Gastrectomy for gastric cancer: definitions and objectives. Br J Surg. 1986 Jul;73(7):513–514. doi: 10.1002/bjs.1800730702. [DOI] [PubMed] [Google Scholar]
- Gaffney E. F. Favourable prognosis in gastric carcinoma with parietal cell differentiation. Histopathology. 1987 Feb;11(2):217–218. [PubMed] [Google Scholar]
- LAUREN P. THE TWO HISTOLOGICAL MAIN TYPES OF GASTRIC CARCINOMA: DIFFUSE AND SO-CALLED INTESTINAL-TYPE CARCINOMA. AN ATTEMPT AT A HISTO-CLINICAL CLASSIFICATION. Acta Pathol Microbiol Scand. 1965;64:31–49. doi: 10.1111/apm.1965.64.1.31. [DOI] [PubMed] [Google Scholar]
- Nagata T., Ikeda M., Nakayama F. Changing state of gastric cancer in Japan. Histologic perspective of the past 76 years. Am J Surg. 1983 Feb;145(2):226–233. doi: 10.1016/0002-9610(83)90068-5. [DOI] [PubMed] [Google Scholar]
- Sasano N., Nakamura K., Arai M., Akazaki K. Ultrastructural cell patterns in human gastric carcinoma compared with non-neoplastic gastric mucosa--histogenetic analysis of carcinoma by mucin histochemistry. J Natl Cancer Inst. 1969 Oct;43(4):783–802. [PubMed] [Google Scholar]
- Yamashiro K., Suzuki H., Nagayo T. Electron microscopic study of signet-ring cells in diffuse carcinoma of the human stomach. Virchows Arch A Pathol Anat Histol. 1977 Jul 11;374(4):275–284. doi: 10.1007/BF00432651. [DOI] [PubMed] [Google Scholar]