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. 1988 Mar;57(3):277–280. doi: 10.1038/bjc.1988.59

Response to flavone acetic acid (NSC 347512) of primary and metastatic human colorectal carcinoma xenografts.

R Giavazzi 1, A Garofalo 1, G Damia 1, S Garattini 1, M D'Incalci 1
PMCID: PMC2246519  PMID: 3355765

Abstract

The antitumour activity of flavone acetic acid (FAA) was evaluated against two human colorectal carcinoma (HCC) lines, HCC-P2988 and HCC-M1410, transplanted into nude mice. On repeated i.v. injection of 200 mg kg-1 every 4 days FAA was moderately active against the s.c. growing HCC-P2988. HCC-M1410 transplanted s.c. was almost unresponsive in the same experimental conditions. In contrast, FAA (200 mg kg-1 i.v. every 4 days, repeated three times) significantly reduced liver tumour colonies produced by the HCC-M1410 cells injected intrasplenically into nude mice. These findings suggest that FAA has potential activity against human colorectal carcinoma, particularly against liver metastases.

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Selected References

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