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. 1988 Apr;57(4):374–377. doi: 10.1038/bjc.1988.85

Loss of polymorphic A and B locus HLA antigens in colon carcinoma.

R C Rees 1, A M Buckle 1, K Gelsthorpe 1, V James 1, C W Potter 1, K Rogers 1, G Jacob 1
PMCID: PMC2246567  PMID: 3291922

Abstract

In the present study we have confirmed that approximately one third of human colorectal carcinomas fail to express the HLA - A,B,C monomorphic determinant reactive with the W6/32 MAb, and 44% express class II HLA antigens as shown by reactivity with NFK-1 MAb. Reduced staining with the W6/32 MAb was not always associated with the loss of beta 2m. In addition, the expression of HLA-A2 and Bw4 class I specific haplotypes on normal colon epithelium and tumour biopsy tissue was assessed. All normal colonic epithelia stained positively with MAb against A2 and Bw4 antigens, but a loss of these determinants was shown on tumour biopsies from patients tissue typed for the respective specificities. Loss of the A2 haplotype was shown in 4 of 15 tumour tissue samples, and loss of Bw4 specificities in 5 out of 7 tissue samples. The failure to detect specific loci determinants was not necessarily associated with loss of reactivity with W6/32 MAb.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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