Skip to main content
PMC home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1988 Jan;57(1):105–108. doi: 10.1038/bjc.1988.19

Serum thyroglobulin as a preclinical tumour marker in subgroups of thyroid cancer.

S O Thoresen 1, O Myking 1, E Glattre 1, K Rootwelt 1, A Andersen 1, O P Foss 1
PMCID: PMC2246681  PMID: 3348941

Abstract

Serum samples from a biological serum bank taken several years before the diagnosis of cancer, were analysed for S-Tg and S-TSH in 43 patients with thyroid cancer and compared to 128 healthy controls matched for age, sex, geographical region and time of blood sampling. The main finding was the difference in S-Tg between cases and controls, the highest values being found in sera from cases. Relative risk of thyroid cancer increases with increasing S-Tg levels (the global test giving P less than 0.0005). Extremely high levels were found in 4 cases with follicular and 3 with anaplastic cancers. No such statistically significant difference was found in S-TSH concentration. Possible explanations for the elevated S-Tg observed several years before clinically evident malignant tumour are discussed.

Full text

PDF
105

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Black E. G., Cassoni A., Gimlette T. M., Harmer C. L., Maisey M. N., Oates G. D., Hoffenberg R. Serum thyroglobulin in thyroid cancer. Lancet. 1981 Aug 29;2(8244):443–445. doi: 10.1016/s0140-6736(81)90776-5. [DOI] [PubMed] [Google Scholar]
  2. Christensen S. B., Ljungberg O., Tibblin S. Thyroid carcinoma in Malmö, 1960-1977. Epidemiologic, clinical, and prognostic findings in a defined urban population. Cancer. 1984 Apr 1;53(7):1625–1633. doi: 10.1002/1097-0142(19840401)53:7<1625::aid-cncr2820530735>3.0.co;2-9. [DOI] [PubMed] [Google Scholar]
  3. Ericsson U. B., Tegler L., Lennquist S., Christensen S. B., Ståhl E., Thorell J. I. Serum thyroglobulin in differentiated thyroid carcinoma. Acta Chir Scand. 1984;150(5):367–375. [PubMed] [Google Scholar]
  4. Feldt-Rasmussen U., Hansen H. S., Rasmusson B. Serum-tyreoglobulin-bestemmelse ved differentieret thyreoideakarcinom. En oversigt samt 3 sygehistorier. Ugeskr Laeger. 1983 Apr 11;145(15):1132–1136. [PubMed] [Google Scholar]
  5. Girelli M. E., Busnardo B., Amerio R., Scotton G., Casara D., Betterle C., Piccolo M., Pelizzo M. R. Serum thyroglobulin levels in patients with well-differentiated thyroid cancer during suppression therapy: study on 429 patients. Eur J Nucl Med. 1985;10(5-6):252–254. doi: 10.1007/BF00254469. [DOI] [PubMed] [Google Scholar]
  6. Thoresen S. O., Glattre E., Johansen A. Thyreoidea cancer i Norge 1970-79. Regional variasjon av histologiske typer. Tidsskr Nor Laegeforen. 1986 Nov 10;106(31):2616–2620. [PubMed] [Google Scholar]
  7. Torrigiani G., Doniach D., Roitt I. M. Serum thyroglobulin levels in healthy subjects and in patients with thyroid disease. J Clin Endocrinol Metab. 1969 Mar;29(3):305–314. doi: 10.1210/jcem-29-3-305. [DOI] [PubMed] [Google Scholar]
  8. Williams E. D., Doniach I., Bjarnason O., Michie W. Thyroid cancer in an iodide rich area: a histopathological study. Cancer. 1977 Jan;39(1):215–222. doi: 10.1002/1097-0142(197701)39:1<215::aid-cncr2820390134>3.0.co;2-#. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES