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. 1988 Nov;58(5):570–574. doi: 10.1038/bjc.1988.261

In vitro sensitivity of clonogenic cells in resisting and relapsing patients with acute myelogenous leukaemia.

J P Marie 1, R Zittoun 1, D Thevenin 1
PMCID: PMC2246830  PMID: 3219266

Abstract

The evolution of in vitro bone marrow clonogenic leukaemic cells (CFU-L) drug sensitivity was studied in 23 patients with acute myeloid leukaemia treated with anthracycline and cytosine arbinoside (ara-C). In 12 patients tested before and after first induction treatment failure (interval: 6 +/- 4 weeks), the sensitivity remained stable for daunorubicin and showed little variation for ara-C. Among eleven patients tested before treatment and at first relapse (interval: 13 +/- 7 months), in vitro CFU-L sensitivity revealed no correlation between the two measurements, and a trend in decreased sensitivity to daunorubicin and ara-C. These findings suggest that induction failures could be related to factors other than simple selection of a resistant CFU-L subclone.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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