Skip to main content
NCBI home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1988 Dec;58(6):710–714. doi: 10.1038/bjc.1988.295

Partial deletion of chromosome 11p in breast cancer correlates with size of primary tumour and oestrogen receptor level.

J Mackay 1, P A Elder 1, D J Porteous 1, C M Steel 1, R A Hawkins 1, J J Going 1, U Chetty 1
PMCID: PMC2246883  PMID: 3066395

Abstract

In a study of DNAs from 100 breast cancer patients and 100 controls, there were no differences in the frequencies of common or rare alleles at the Harvey ras (c-Ha-ras) locus on chromosome 11. However, one Ha-ras allele was deleted from the tumour DNA in 14 of 65 informative patients. Loss of a Ha-ras allele correlates with paucity of oestrogen receptor protein and with increased tumour size at presentation, but is not associated with microscopic evidence of lymph node invasion. The findings on Ha-ras and other informative loci are consistent with the possibility that a tumour suppressor gene involved in the early stages of breast cancer is located on the short arm of chromosome 11.

Full text

PDF
710

Images in this article

711Figure 1
on p.711
711Figure 2
on p.711

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ali I. U., Lidereau R., Theillet C., Callahan R. Reduction to homozygosity of genes on chromosome 11 in human breast neoplasia. Science. 1987 Oct 9;238(4824):185–188. doi: 10.1126/science.3659909. [DOI] [PubMed] [Google Scholar]
  2. Capon D. J., Chen E. Y., Levinson A. D., Seeburg P. H., Goeddel D. V. Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue. Nature. 1983 Mar 3;302(5903):33–37. doi: 10.1038/302033a0. [DOI] [PubMed] [Google Scholar]
  3. Cavenee W. K., Dryja T. P., Phillips R. A., Benedict W. F., Godbout R., Gallie B. L., Murphree A. L., Strong L. C., White R. L. Expression of recessive alleles by chromosomal mechanisms in retinoblastoma. 1983 Oct 27-Nov 2Nature. 305(5937):779–784. doi: 10.1038/305779a0. [DOI] [PubMed] [Google Scholar]
  4. Croton R., Cooke T., Holt S., George W. D., Nicolson R., Griffiths K. Oestrogen receptors and survival in early breast cancer. Br Med J (Clin Res Ed) 1981 Nov 14;283(6302):1289–1291. doi: 10.1136/bmj.283.6302.1289. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Deisseroth A., Nienhuis A., Lawrence J., Giles R., Turner P., Ruddle F. H. Chromosomal localization of human beta globin gene on human chromosome 11 in somatic cell hybrids. Proc Natl Acad Sci U S A. 1978 Mar;75(3):1456–1460. doi: 10.1073/pnas.75.3.1456. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Friend S. H., Dryja T. P., Weinberg R. A. Oncogenes and tumor-suppressing genes. N Engl J Med. 1988 Mar 10;318(10):618–622. doi: 10.1056/NEJM198803103181007. [DOI] [PubMed] [Google Scholar]
  7. Gosden J. R., Middleton P. G., Rout D., De Angelis C. Chromosomal localization of the human oncogene ERBA2. Cytogenet Cell Genet. 1986;43(3-4):150–153. doi: 10.1159/000132313. [DOI] [PubMed] [Google Scholar]
  8. Gustafsson K., Wiman K., Emmoth E., Larhammar D., Böhme J., Hyldig-Nielsen J. J., Ronne H., Peterson P. A., Rask L. Mutations and selection in the generation of class II histocompatibility antigen polymorphism. EMBO J. 1984 Jul;3(7):1655–1661. doi: 10.1002/j.1460-2075.1984.tb02026.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Hawkins R. A., Black R., Steele R. J., Dixon J. M., Forrest A. P. Oestrogen receptor concentration in primary breast cancer and axillary node metastases. Breast Cancer Res Treat. 1981;1(3):245–251. doi: 10.1007/BF01806264. [DOI] [PubMed] [Google Scholar]
  10. Hayward N. K., Keegan R., Nancarrow D. J., Little M. H., Smith P. J., Gardiner R. A., Seymour G. J., Kidson C., Lavin M. F. c-Ha-ras-1 alleles in bladder cancer, Wilms' tumour and malignant melanoma. Hum Genet. 1988 Feb;78(2):115–120. doi: 10.1007/BF00278178. [DOI] [PubMed] [Google Scholar]
  11. Heighway J., Thatcher N., Cerny T., Hasleton P. S. Genetic predisposition to human lung cancer. Br J Cancer. 1986 Apr;53(4):453–457. doi: 10.1038/bjc.1986.72. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Höppener J. W., Steenbergh P. H., Zandberg J., Bakker E., Pearson P. L., Geurts van Kessel A. H., Jansz H. S., Lips C. J. Localization of the polymorphic human calcitonin gene on chromosome 11. Hum Genet. 1984;66(4):309–312. doi: 10.1007/BF00287635. [DOI] [PubMed] [Google Scholar]
  13. Knudson A. G., Jr Hereditary cancer, oncogenes, and antioncogenes. Cancer Res. 1985 Apr;45(4):1437–1443. [PubMed] [Google Scholar]
  14. Knudson A. G., Jr Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci U S A. 1971 Apr;68(4):820–823. doi: 10.1073/pnas.68.4.820. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Kok K., Osinga J., Carritt B., Davis M. B., van der Hout A. H., van der Veen A. Y., Landsvater R. M., de Leij L. F., Berendsen H. H., Postmus P. E. Deletion of a DNA sequence at the chromosomal region 3p21 in all major types of lung cancer. Nature. 1987 Dec 10;330(6148):578–581. doi: 10.1038/330578a0. [DOI] [PubMed] [Google Scholar]
  16. Koufos A., Hansen M. F., Copeland N. G., Jenkins N. A., Lampkin B. C., Cavenee W. K. Loss of heterozygosity in three embryonal tumours suggests a common pathogenetic mechanism. Nature. 1985 Jul 25;316(6026):330–334. doi: 10.1038/316330a0. [DOI] [PubMed] [Google Scholar]
  17. Krontiris T. G., DiMartino N. A., Colb M., Parkinson D. R. Unique allelic restriction fragments of the human Ha-ras locus in leukocyte and tumour DNAs of cancer patients. 1985 Jan 31-Feb 6Nature. 313(6001):369–374. doi: 10.1038/313369a0. [DOI] [PubMed] [Google Scholar]
  18. Leclercq G., Bojar H., Goussard J., Nicholson R. I., Pichon M. F., Piffanelli A., Pousette A., Thorpe S., Lonsdorfer M. Abbott monoclonal enzyme immunoassay measurement of estrogen receptors in human breast cancer: a European multicenter study. Cancer Res. 1986 Aug;46(8 Suppl):4233s–4236s. [PubMed] [Google Scholar]
  19. Lidereau R., Escot C., Theillet C., Champeme M. H., Brunet M., Gest J., Callahan R. High frequency of rare alleles of the human c-Ha-ras-1 proto-oncogene in breast cancer patients. J Natl Cancer Inst. 1986 Sep;77(3):697–701. doi: 10.1093/jnci/77.3.697. [DOI] [PubMed] [Google Scholar]
  20. Lundberg C., Skoog L., Cavenee W. K., Nordenskjöld M. Loss of heterozygosity in human ductal breast tumors indicates a recessive mutation on chromosome 13. Proc Natl Acad Sci U S A. 1987 Apr;84(8):2372–2376. doi: 10.1073/pnas.84.8.2372. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. McBride O. W., Swan D. C., Santos E., Barbacid M., Tronick S. R., Aaronson S. A. Localization of the normal allele of T24 human bladder carcinoma oncogene to chromosome 11. Nature. 1982 Dec 23;300(5894):773–774. doi: 10.1038/300773a0. [DOI] [PubMed] [Google Scholar]
  22. Moore D. H., Moore D. H., 2nd, Moore C. T. Breast carcinoma etiological factors. Adv Cancer Res. 1983;40:189–253. doi: 10.1016/s0065-230x(08)60681-8. [DOI] [PubMed] [Google Scholar]
  23. Porteous D. J., Bickmore W., Christie S., Boyd P. A., Cranston G., Fletcher J. M., Gosden J. R., Rout D., Seawright A., Simola K. O. HRAS1-selected chromosome transfer generates markers that colocalize aniridia- and genitourinary dysplasia-associated translocation breakpoints and the Wilms tumor gene within band 11p13. Proc Natl Acad Sci U S A. 1987 Aug;84(15):5355–5359. doi: 10.1073/pnas.84.15.5355. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Rigby P. W., Dieckmann M., Rhodes C., Berg P. Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. J Mol Biol. 1977 Jun 15;113(1):237–251. doi: 10.1016/0022-2836(77)90052-3. [DOI] [PubMed] [Google Scholar]
  25. Roberts M. M., Hawkins R. A., Alexander F. E., Anderson T. J., Steele R. J. Oestrogen receptor activity in breast cancer detected at a prevalence screening examination. Breast Cancer Res Treat. 1987 Dec;10(3):267–272. doi: 10.1007/BF01805763. [DOI] [PubMed] [Google Scholar]
  26. Roberts R. J., Wilson G. A., Young F. E. Recognition sequence of specific endonuclease BamH.I from Bacillus amyloliquefaciens H. Nature. 1977 Jan 6;265(5589):82–84. doi: 10.1038/265082a0. [DOI] [PubMed] [Google Scholar]
  27. Seizinger B. R., Martuza R. L., Gusella J. F. Loss of genes on chromosome 22 in tumorigenesis of human acoustic neuroma. Nature. 1986 Aug 14;322(6080):644–647. doi: 10.1038/322644a0. [DOI] [PubMed] [Google Scholar]
  28. Shih C., Weinberg R. A. Isolation of a transforming sequence from a human bladder carcinoma cell line. Cell. 1982 May;29(1):161–169. doi: 10.1016/0092-8674(82)90100-3. [DOI] [PubMed] [Google Scholar]
  29. Solomon E., Voss R., Hall V., Bodmer W. F., Jass J. R., Jeffreys A. J., Lucibello F. C., Patel I., Rider S. H. Chromosome 5 allele loss in human colorectal carcinomas. Nature. 1987 Aug 13;328(6131):616–619. doi: 10.1038/328616a0. [DOI] [PubMed] [Google Scholar]
  30. Taggart R. T., Mohandas T. K., Bell G. I. Parasexual analysis of human pepsinogen molecular heterogeneity. Somat Cell Mol Genet. 1987 Mar;13(2):167–172. doi: 10.1007/BF01534696. [DOI] [PubMed] [Google Scholar]
  31. Taggart R. T., Mohandas T. K., Shows T. B., Bell G. I. Variable numbers of pepsinogen genes are located in the centromeric region of human chromosome 11 and determine the high-frequency electrophoretic polymorphism. Proc Natl Acad Sci U S A. 1985 Sep;82(18):6240–6244. doi: 10.1073/pnas.82.18.6240. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Theillet C., Lidereau R., Escot C., Hutzell P., Brunet M., Gest J., Schlom J., Callahan R. Loss of a c-H-ras-1 allele and aggressive human primary breast carcinomas. Cancer Res. 1986 Sep;46(9):4776–4781. [PubMed] [Google Scholar]
  33. Thein S. L., Oscier D. G., Flint J., Wainscoat J. S. Ha-ras hypervariable alleles in myelodysplasia. Nature. 1986 May 1;321(6065):84–85. doi: 10.1038/321084a0. [DOI] [PubMed] [Google Scholar]
  34. Williams M. R., Todd J. H., Ellis I. O., Dowle C. S., Haybittle J. L., Elston C. W., Nicholson R. I., Griffiths K., Blamey R. W. Oestrogen receptors in primary and advanced breast cancer: an eight year review of 704 cases. Br J Cancer. 1987 Jan;55(1):67–73. doi: 10.1038/bjc.1987.14. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Wong Z., Wilson V., Patel I., Povey S., Jeffreys A. J. Characterization of a panel of highly variable minisatellites cloned from human DNA. Ann Hum Genet. 1987 Oct;51(Pt 4):269–288. doi: 10.1111/j.1469-1809.1987.tb01062.x. [DOI] [PubMed] [Google Scholar]
  36. Wyllie F. S., Wynford-Thomas V., Lemoine N. R., Williams G. T., Williams E. D., Wynford-Thomas D. Ha-ras restriction fragment length polymorphisms in colorectal cancer. Br J Cancer. 1988 Feb;57(2):135–138. doi: 10.1038/bjc.1988.28. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES