Skip to main content
PMC home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1989 Apr;59(4):594–599. doi: 10.1038/bjc.1989.120

Cervical intraepithelial neoplasia in lymphoma patients: a cytological and colposcopic study.

R G Hughes 1, M Colquhoun 1, D M Eccles 1, M Alloub 1, A C Parker 1, M Norval 1, G E Smart 1
PMCID: PMC2247154  PMID: 2713244

Abstract

Twenty-seven patients with Hodgkin's (n = 19) and non-Hodgkin's (n = 8) lymphomas underwent cytological and colposcopic screening of the uterine cervix. Colposcopically directed cervical punch biopsies were taken from all patients in whom a colposcopic abnormality was detected. Lymphoma patients were compared with 79 controls with normal cervical cytology and no known haematological abnormality. Colposcopically directed punch biopsies were taken from the cervical transformation zone of all controls. Significantly more lymphoma patients (19%) than controls (3%) had CIN II or III (P less than 0.01) and cervical human papillomavirus infection, as judged by the presence of koilocytes (52% of lymphoma patients; 27% of controls; P less than 0.02). All six lymphoma patients with CIN had Hodgkin's disease (HD), and five had received combination chemotherapy. Half of the cases of CIN in lymphoma patients and all the cases of CIN in control patients were not detected by cervical cytology. This study suggests that female patients with HD are at increased risk of CIN, and that cervical cytology alone may be an inadequate form of screening for these patients.

Full text

PDF
594

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arseneau J. C., Sponzo R. W., Levin D. L., Schnipper L. E., Bonner H., Young R. C., Canellos G. P., Johnson R. E., DeVita V. T. Nonlymphomatous malignant tumors complicating Hodgkin's disease. Possible association with intensive therapy. N Engl J Med. 1972 Nov 30;287(22):1119–1122. doi: 10.1056/NEJM197211302872204. [DOI] [PubMed] [Google Scholar]
  2. Bergmann L., Mitrou P. S., Demmer-Dieckmann M., Ruhmann F. T., Weidmann E. Impaired T- and B-cell functions in patients with Hodgkin's disease. Reduced mitogenic responsibility and Il-2 production is not caused by defective CD4+-cells. Cancer Immunol Immunother. 1987;25(1):59–64. doi: 10.1007/BF00199302. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Buckley C. H., Butler E. B., Fox H. Cervical intraepithelial neoplasia. J Clin Pathol. 1982 Jan;35(1):1–13. doi: 10.1136/jcp.35.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Campion M. J., McCance D. J., Cuzick J., Singer A. Progressive potential of mild cervical atypia: prospective cytological, colposcopic, and virological study. Lancet. 1986 Aug 2;2(8501):237–240. doi: 10.1016/s0140-6736(86)92067-2. [DOI] [PubMed] [Google Scholar]
  5. Giles J. A., Hudson E., Crow J., Williams D., Walker P. Colposcopic assessment of the accuracy of cervical cytology screening. Br Med J (Clin Res Ed) 1988 Apr 16;296(6629):1099–1102. doi: 10.1136/bmj.296.6629.1099. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Jacquillat C., Khayat D., Desprez-Curely J. P., Weil M., Brocheriou C., Auclerc G., Chamseddine N., Bernard J. Non-Hodgkin's lymphoma occurring after Hodgkin's disease. Four new cases and a review of the literature. Cancer. 1984 Feb 1;53(3):459–462. doi: 10.1002/1097-0142(19840201)53:3<459::aid-cncr2820530315>3.0.co;2-v. [DOI] [PubMed] [Google Scholar]
  7. Koss L. G. Dysplasia. A real concept or a misnomer? Obstet Gynecol. 1978 Mar;51(3):374–379. [PubMed] [Google Scholar]
  8. La Vecchia C. The epidemiology of cervical neoplasia. Biomed Pharmacother. 1985;39(8):426–433. [PubMed] [Google Scholar]
  9. Meisels A., Fortin R. Condylomatous lesions of the cervix and vagina. I. Cytologic patterns. Acta Cytol. 1976 Nov-Dec;20(6):505–509. [PubMed] [Google Scholar]
  10. Morison W. L. Viral warts, herpes simplex and herpes zoster in patients with secondary immune deficiencies and neoplasms. Br J Dermatol. 1975 Jun;92(6):625–630. doi: 10.1111/j.1365-2133.1975.tb03141.x. [DOI] [PubMed] [Google Scholar]
  11. Pedersen-Bjergaard J., Ersbøll J., Sørensen H. M., Keiding N., Larsen S. O., Philip P., Larsen M. S., Schultz H., Nissen N. I. Risk of acute nonlymphocytic leukemia and preleukemia in patients treated with cyclophosphamide for non-Hodgkin's lymphomas. Comparison with results obtained in patients treated for Hodgkin's disease and ovarian carcinoma with other alkylating agents. Ann Intern Med. 1985 Aug;103(2):195–200. doi: 10.7326/0003-4819-103-2-195. [DOI] [PubMed] [Google Scholar]
  12. Porreco R., Penn I., Droegemueller W., Greer B., Makowski E. Gynecologic malignancies in immunosuppressed organ homograft recipients. Obstet Gynecol. 1975 Apr;45(4):359–364. [PubMed] [Google Scholar]
  13. Rüdlinger R., Smith I. W., Bunney M. H., Hunter J. A. Human papillomavirus infections in a group of renal transplant recipients. Br J Dermatol. 1986 Dec;115(6):681–692. doi: 10.1111/j.1365-2133.1986.tb06649.x. [DOI] [PubMed] [Google Scholar]
  14. Schneider V., Kay S., Lee H. M. Immunosuppression as a high-risk factor in the development of condyloma acuminatum and squamous neoplasia of the cervix. Acta Cytol. 1983 May-Jun;27(3):220–224. [PubMed] [Google Scholar]
  15. Shokri-Tabibzadeh S., Koss L. G., Molnar J., Romney S. Association of human papillomavirus with neoplastic processes in the genital tract of four women with impaired immunity. Gynecol Oncol. 1981 Oct;12(2 Pt 2):S129–S140. doi: 10.1016/0090-8258(81)90068-8. [DOI] [PubMed] [Google Scholar]
  16. Sillman F., Stanek A., Sedlis A., Rosenthal J., Lanks K. W., Buchhagen D., Nicastri A., Boyce J. The relationship between human papillomavirus and lower genital intraepithelial neoplasia in immunosuppressed women. Am J Obstet Gynecol. 1984 Oct 1;150(3):300–308. doi: 10.1016/s0002-9378(84)90369-7. [DOI] [PubMed] [Google Scholar]
  17. Streilein J. W. Lymphocyte traffic, T-cell malignancies and the skin. J Invest Dermatol. 1978 Sep;71(3):167–171. doi: 10.1111/1523-1747.ep12547071. [DOI] [PubMed] [Google Scholar]
  18. Tester W. J., Kinsella T. J., Waller B., Makuch R. W., Kelley P. A., Glatstein E., DeVita V. T. Second malignant neoplasms complicating Hodgkin's disease: the National Cancer Institute experience. J Clin Oncol. 1984 Jul;2(7):762–769. doi: 10.1200/JCO.1984.2.7.762. [DOI] [PubMed] [Google Scholar]
  19. Winkelstein W., Jr, Shillitoe E. J., Brand R., Johnson K. K. Further comments on cancer of the uterine cervix, smoking, and herpesvirus infection. Am J Epidemiol. 1984 Jan;119(1):1–8. doi: 10.1093/oxfordjournals.aje.a113711. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES