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. 1989 May;59(5):692–695. doi: 10.1038/bjc.1989.144

Expression of the small cell carcinoma antigens of cluster-5 and cluster-5A in primary lung tumours.

A Maier 1, U Schmidt 1, R Waibel 1, W Hartung 1, R A Stahel 1
PMCID: PMC2247226  PMID: 2544218

Abstract

The expression of the small cell carcinoma (SCLC) antigens cluster-5 (antibody LAM8) and cluster-5A (antibody SWA20) was examined on a panel of routinely processed biopsy or surgical specimens of 290 lung tumours by immunoperoxidase staining. Antigen expression was largely restricted to SCLC. Of over 150 tissue samples evaluated, moderate or strong antigen expression was found in 49% (cluster-5) and 45% (cluster-5A). Concordance in expression of the two antigens was seen in 71% of SCLC samples, with 35% expressing both antigens strongly, 8% moderately and 28% being negative for both antigens. Antigen expression was independent of the morphological subtype of SCLC. Primary lung tumours of other histology, including squamous cell carcinoma, large cell carcinoma, adenocarcinoma, mesothelioma or carcinoid had no significant antigen expression. Of 135 tumours, strong or moderate expression of both antigens was seen only in two cases. 20%, mostly carcinoids, were weakly positive for cluster 5 and 4% for cluster 5A antigen. The remainder were antigen negative. No significant antigen expression was seen in 25 normal lung tissues. The membrane antigens of SCLC cluster 5 and 5A are markers for SCLC and their expression in tissues is tumour-associated.

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Selected References

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  1. Baylin S. B., Gazdar A. F., Minna J. D., Bernal S. D., Shaper J. H. A unique cell-surface protein phenotype distinguishes human small-cell from non-small-cell lung cancer. Proc Natl Acad Sci U S A. 1982 Aug;79(15):4650–4654. doi: 10.1073/pnas.79.15.4650. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bernal S., Weinberg K., Kakefuda M., Stahel R., O'Hara C., Wong Y. C. Membrane antigens of human bronchial epithelial cells identified by monoclonal antibodies. In Vitro Cell Dev Biol. 1988 Feb;24(2):117–125. doi: 10.1007/BF02623888. [DOI] [PubMed] [Google Scholar]
  3. Caillaud J. M., Benjelloun S., Bosq J., Braham K., Lipinski M. HNK-1-defined antigen detected in paraffin-embedded neuroectoderm tumors and those derived from cells of the amine precursor uptake and decarboxylation system. Cancer Res. 1984 Oct;44(10):4432–4439. [PubMed] [Google Scholar]
  4. International Federation of Gynecology and Obstetrics FIGO. World Health Organization WHO FIGO/WHO Workshop on Innovative Approaches to Maternal and Neonatal Care As Part of Primary Health Care, Tokyo, 22-24 October, 1979. Malays J Reprod Health. 1984 Dec;2(2):123–127. [PubMed] [Google Scholar]
  5. Souhami R. L., Beverley P. C., Bobrow L. G. Antigens of small-cell lung cancer. First International Workshop. Lancet. 1987 Aug 8;2(8554):325–326. doi: 10.1016/s0140-6736(87)90904-4. [DOI] [PubMed] [Google Scholar]
  6. Stahel R. A., O'Hara C. J., Mabry M., Waibel R., Sabbath K., Speak J. A., Bernal S. D. Cytotoxic murine monoclonal antibody LAM8 with specificity for human small cell carcinoma of the lung. Cancer Res. 1986 Apr;46(4 Pt 2):2077–2084. [PubMed] [Google Scholar]
  7. Stahel R. A., Speak J. A., Bernal S. D. Murine monoclonal antibody LAM2 defines cell membrane determinant with preferential expression on human lung small-cell carcinoma and squamous-cell carcinomas. Int J Cancer. 1985 Jan 15;35(1):11–17. doi: 10.1002/ijc.2910350104. [DOI] [PubMed] [Google Scholar]
  8. Takahashi T., Ueda R., Song X., Nishida K., Shinzato M., Namikawa R., Ariyoshi Y., Ota K., Kato K., Nagatsu T. Two novel cell surface antigens on small cell lung carcinoma defined by mouse monoclonal antibodies NE-25 and PE-35. Cancer Res. 1986 Sep;46(9):4770–4775. [PubMed] [Google Scholar]
  9. Waibel R., O'Hara C. J., Smith A., Stahel R. A. Tumor-associated membrane sialoglycoprotein on human small cell lung carcinoma identified by the IgG2a monoclonal antibody SWA20. Cancer Res. 1988 Aug 1;48(15):4318–4323. [PubMed] [Google Scholar]
  10. Waibel R., O'Hara C. J., Stahel R. A. Characterization of an epithelial and a tumor-associated human small cell lung carcinoma glycoprotein antigen. Cancer Res. 1987 Jul 15;47(14):3766–3770. [PubMed] [Google Scholar]
  11. Watanabe J., Okabe T., Fujisawa M., Takaku F., Hirohashi S., Shimosato Y. Monoclonal antibody that distinguishes small-cell lung cancer from non-small-cell lung cancer. Cancer Res. 1987 Feb 1;47(3):826–829. [PubMed] [Google Scholar]
  12. de Leij L., Poppema S., Nulend J. K., ter Haar A., Schwander E., Ebbens F., Postmus P. E., The T. H. Neuroendocrine differentiation antigen on human lung carcinoma and Kulchitski cells. Cancer Res. 1985 May;45(5):2192–2200. [PubMed] [Google Scholar]

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