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. 1989 May;59(5):755–760. doi: 10.1038/bjc.1989.158

Thyroid epithelial cell transformation by a retroviral vector expressing SV40 large T.

J S Burns 1, L Lemoine 1, N R Lemoine 1, E D Williams 1, D Wynford-Thomas 1
PMCID: PMC2247228  PMID: 2544221

Abstract

A recombinant murine retroviral vector encoding the SV40 virus large T antigen was used to infect stably an immortal line of differentiated rat thyroid epithelial cells, FRTL-5. Expression of SV40 T transformed these cells to anchorage independence and tumorigenicity but did not alter morphology or abolish tissue-specific functions and growth factor requirements. The resulting phenotype provides a model of well-differentiated human thyroid cancer.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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