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. 1989 Jul;60(1):126–131. doi: 10.1038/bjc.1989.235

A pilot trial to evaluate the acute toxicity and feasibility of tamoxifen for prevention of breast cancer.

T J Powles 1, J R Hardy 1, S E Ashley 1, G M Farrington 1, D Cosgrove 1, J B Davey 1, M Dowsett 1, J A McKinna 1, A G Nash 1, H D Sinnett 1, et al.
PMCID: PMC2247327  PMID: 2679843

Abstract

Epidemiological and experimental evidence indicates that oestrogens are involved in the carcinogenic promotion of human breast cancer. We have undertaken a pilot trial of tamoxifen, an anti-oestrogen, compared to placebo given to 200 women at a high risk of developing breast cancer. The results of this trial show that acute toxicity is low and that accrual and compliance are satisfactory. Furthermore, biochemical monitoring of lipids and clotting factors indicate that tamoxifen may reduce the risk of cardiovascular deaths. At this stage no untoward long-term risks have been identified, and it is therefore proposed that a large multicentre trial should be started.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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