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. Author manuscript; available in PMC: 2009 Feb 3.
Published in final edited form as: Toxicology. 2007 Nov 7;244(1):25–34. doi: 10.1016/j.tox.2007.10.027

Figure 4. Lipid peroxidation was reduced by SAMe and NAC treatment 1 h after APAP injection.

Figure 4

Animals were randomly divided into vehicle (VEH), acetaminophen treated (APAP), SAMe (500 mg/kg, 1.25 mmol/kg) treated (SAMe), N-acetylcysteine treated (NAC), SAMe administered 1 h after APAP injection (SAMe+APAP) and NAC administered 1 h after APAP injection (NAC+APAP). APAP was injected (ip) at a dose of 250 mg/kg (15 ml/kg). VEH treated were injected with water (15 ml/kg). Lipid peroxidation was reported as nmol malondialdehyde (MDA) per mg protein. Lipid peroxidation was measured in hepatic tissue collected 4 h after APAP injection. Values represent MEAN ± SE. Groups with dissimilar superscripts are different (p<0.05) from each other. SAMe and NAC administered 1 h after APAP diminished the extent of hepatic lipid peroxidation.