Abstract
The control of oxygen delivery to mechanically ventilated newborn infants is a time intensive process that must balance adequate tissue oxygenation against possible toxic effects of oxygen exposure. Investigation in computer assisted control of mechanical ventilation is increasing, although very few studies involve newborn infants. We have implemented a fuzzy controller for the adjustment of inspired oxygen concentration (FIO2) in ventilated newborns. The controller utilizes rules produced by neonatologists, and operates in real-time. A clinical trial of this controller is currently taking place in the neonatal intensive care unit (NICU) of Children's Hospital, Boston, MA.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- Avery G. B., Glass P. Retinopathy of prematurity: what causes it? Clin Perinatol. 1988 Dec;15(4):917–928. [PubMed] [Google Scholar]
- Carollo A., Tobar A., Hernandez C. A rule-based postoperative pain controller: simulation results. Int J Biomed Comput. 1993 Nov;33(3-4):267–276. doi: 10.1016/0020-7101(93)90040-d. [DOI] [PubMed] [Google Scholar]
- East T. D., Böhm S. H., Wallace C. J., Clemmer T. P., Weaver L. K., Orme J. F., Jr, Morris A. H. A successful computerized protocol for clinical management of pressure control inverse ratio ventilation in ARDS patients. Chest. 1992 Mar;101(3):697–710. doi: 10.1378/chest.101.3.697. [DOI] [PubMed] [Google Scholar]
- Morozoff P. E., Evans R. W. Closed-loop control of SaO2 in the neonate. Biomed Instrum Technol. 1992 Mar-Apr;26(2):117–123. [PubMed] [Google Scholar]
- O'Hara D. A., Bogen D. K., Noordergraaf A. The use of computers for controlling the delivery of anesthesia. Anesthesiology. 1992 Sep;77(3):563–581. doi: 10.1097/00000542-199209000-00024. [DOI] [PubMed] [Google Scholar]
- Rutledge G., Thomsen G., Farr B., Tovar M., Sheiner L., Fagan L. VentPlan: a ventilator-management advisor. Proc Annu Symp Comput Appl Med Care. 1991:869–871. [PMC free article] [PubMed] [Google Scholar]
- Saugstad O. D. Oxygen toxicity in the neonatal period. Acta Paediatr Scand. 1990 Oct;79(10):881–892. doi: 10.1111/j.1651-2227.1990.tb11348.x. [DOI] [PubMed] [Google Scholar]
- Strickland J. H., Jr, Hasson J. H. A computer-controlled ventilator weaning system. Chest. 1991 Oct;100(4):1096–1099. doi: 10.1378/chest.100.4.1096. [DOI] [PubMed] [Google Scholar]
- Tong D. A. Weaning patients from mechanical ventilation. A knowledge-based system approach. Comput Methods Programs Biomed. 1991 Aug;35(4):267–278. doi: 10.1016/0169-2607(91)90005-e. [DOI] [PubMed] [Google Scholar]
- Wispe J. R., Roberts R. J. Molecular basis of pulmonary oxygen toxicity. Clin Perinatol. 1987 Sep;14(3):651–666. [PubMed] [Google Scholar]
- Ying H., McEachern M., Eddleman D. W., Sheppard L. C. Fuzzy control of mean arterial pressure in postsurgical patients with sodium nitroprusside infusion. IEEE Trans Biomed Eng. 1992 Oct;39(10):1060–1070. doi: 10.1109/10.161338. [DOI] [PubMed] [Google Scholar]
- Yu C., He W. G., So J. M., Roy R., Kaufman H., Newell J. C. Improvement in arterial oxygen control using multiple-model adaptive control procedures. IEEE Trans Biomed Eng. 1987 Aug;34(8):567–574. doi: 10.1109/tbme.1987.326067. [DOI] [PubMed] [Google Scholar]