Skip to main content
Transactions of the American Clinical and Climatological Association logoLink to Transactions of the American Clinical and Climatological Association
. 1954;65:279–293.

A Comparison of the Effects of Hexamethonium Alone and in Combination with 1-Hydrazinophthalazine (Apresoline) in the Treatment of Hypertension

Edward S Orgain, Charles L Rast Jr, Homer A Sieber
PMCID: PMC2249082  PMID: 13205635

Full text

PDF
279

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BLAINEY J. D. Hexamethonium compounds in the treatment of hypertension. Lancet. 1952 May 17;1(6716):993–996. doi: 10.1016/s0140-6736(52)90641-7. [DOI] [PubMed] [Google Scholar]
  2. CAMPBELL A. J., GRAHAM J. G., MAXWELL R. D. Treatment of hypertension by oral methonium compounds. Br Med J. 1952 Feb 2;1(4752):251–254. doi: 10.1136/bmj.1.4752.251. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. FREIS E. D., FINNERTY F. A., Jr, SCHNAPER N. W., JOHNSON R. L. The treatment of hypertension with hexamethonium. Circulation. 1952 Jan;5(1):20–27. doi: 10.1161/01.cir.5.1.20. [DOI] [PubMed] [Google Scholar]
  4. GRIMSON K. S., ORGAIN E. S., ROWE C. R., Jr, SIEBER H. A. Caution with regard to use of hexamethonium and "apresoline". J Am Med Assoc. 1952 May 17;149(3):215–220. doi: 10.1001/jama.1952.02930200001001. [DOI] [PubMed] [Google Scholar]
  5. HAFKENSCHIEL J. H., LINDAUER M. A. 1-Hydrazinophthalazine; apresoline in the treatment of hypertension: a two year study. Circulation. 1953 Jan;7(1):52–57. doi: 10.1161/01.cir.7.1.52. [DOI] [PubMed] [Google Scholar]
  6. HILKER R. R., RHOADS P. S., BILLINGS C. E. Clinical use of hydralazine and hexamethonium in treatment of hypertension. J Am Med Assoc. 1953 Sep 5;153(1):5–9. doi: 10.1001/jama.1953.02940180007002. [DOI] [PubMed] [Google Scholar]
  7. JOHNSON R. L., FREIS E. D., SCHNAPER H. W. Clinical evaluation of 1-hydrazinophthalazine (C-5968) in hypertension, with special reference to alternating treatment with hexamethonium. Circulation. 1952 Jun;5(6):833–841. doi: 10.1161/01.cir.5.6.833. [DOI] [PubMed] [Google Scholar]
  8. MOYER J. H. Hydrallazine (apresoline) hydrochloride; pharmacological observations and clinical results in the therapy of hypertension. AMA Arch Intern Med. 1953 Apr;91(4):419–439. doi: 10.1001/archinte.1953.00240160005002. [DOI] [PubMed] [Google Scholar]
  9. MOYER J. H., MILLER S. I., FORD R. V. Orally administered hexamethonium chloride in hypertension. J Am Med Assoc. 1953 Jul 18;152(12):1121–1129. doi: 10.1001/jama.1953.03690120037010. [DOI] [PubMed] [Google Scholar]
  10. PALMER R. S., LOOFBOUROW D., DOERING C. R. Prognosis in essential hypertension; 8-year follow-up study of 430 patients on conventional medical treatment. N Engl J Med. 1948 Dec 23;239(26):990–994. doi: 10.1056/NEJM194812232392602. [DOI] [PubMed] [Google Scholar]
  11. REUBI F. C. Renal hyperemia induced in man by a new phthalazine derivative. Proc Soc Exp Biol Med. 1950 Jan;73(1):102–102. doi: 10.3181/00379727-73-17591. [DOI] [PubMed] [Google Scholar]
  12. SCHROEDER H. A. Control of hypertension by hexamethonium and 1-hydrazinophthalazine; preliminary observations. AMA Arch Intern Med. 1952 Apr;89(4):523–540. doi: 10.1001/archinte.1952.00240040002001. [DOI] [PubMed] [Google Scholar]
  13. SCHROEDER H. A., MORROW J. D. The control of arterial hypertension by hyphex, with an evaluation of other methods of therapy. Med Clin North Am. 1953 Jul;1(NATIONWIDE):991–1008. doi: 10.1016/s0025-7125(16)34973-2. [DOI] [PubMed] [Google Scholar]
  14. SCHROEDER N. A. The effect of 1-hydrasinophthalasine in hypertension. Circulation. 1952 Jan;5(1):28–37. doi: 10.1161/01.cir.5.1.28. [DOI] [PubMed] [Google Scholar]
  15. SMIRK F. H., ALSTAD K. S. Treatment of arterial hypertension by penta- and hexamethonium salts; based on 150 tests on hypertensives of varied aetiology and 53 patients treated for periods of two to fourteen months. Br Med J. 1951 Jun 2;1(4717):1217–1228. doi: 10.1136/bmj.1.4717.1217. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. TAYLOR R. D., DUSTAN H. P., CORCORAN A. C., PAGE I. H. Evaluation of l-hydrazinophthalazine (apresoline) in treatment of hypertensive disease. AMA Arch Intern Med. 1952 Dec;90(6):734–749. doi: 10.1001/archinte.1952.00240120009002. [DOI] [PubMed] [Google Scholar]

Articles from Transactions of the American Clinical and Climatological Association are provided here courtesy of American Clinical and Climatological Association

RESOURCES