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. 1988 Apr;100(2):291–299. doi: 10.1017/s095026880006742x

Serological examination of IgE- and IgG-specific antibodies to egg protein during influenza virus immunization.

N Yamane 1, H Uemura 1
PMCID: PMC2249232  PMID: 3356225

Abstract

The concentrations of serum IgE (PRIST) and IgE- and IgG-specific antibodies to egg protein were determined in paired sera taken from students who had received influenza virus vaccine. Although persons who gave a history of allergy to egg or to chicken feathers were excluded, 10-16% of vaccinees possessed higher titres of serum IgE and IgE-specific antibody (RAST) to egg white (F1) allergen before vaccination. The titres of IgG-specific antibody to egg protein (ovalbumin and ovomucoid antigens) were negligible, and did not show any significant response after vaccination. In contrast, IgE-specific antibody to F1 allergen rose significantly in a considerable number of the vaccines. The results obtained indicate possible contamination of vaccine products with allergens of egg origin and a potential risk of allergic manifestation after influenza vaccination.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Davies R., Pepys J. Egg allergy, influenza vaccine, and immunoglobulin E antibody. J Allergy Clin Immunol. 1976 Apr;57(4):373–383. doi: 10.1016/0091-6749(76)90095-6. [DOI] [PubMed] [Google Scholar]
  2. Francis T., Jr Epidemic influenza: immunization and control. Med Clin North Am. 1967 May;51(3):781–790. doi: 10.1016/s0025-7125(16)33046-2. [DOI] [PubMed] [Google Scholar]
  3. Hosoi S., Shinomiya K., Nakano H., Mikawa H., Harada S. Monoclonal anti-human IgG antibodies for quantitation of allergen-specific IgG in human sera. J Allergy Clin Immunol. 1985 Feb;75(2):320–327. doi: 10.1016/0091-6749(85)90064-8. [DOI] [PubMed] [Google Scholar]
  4. Ishizaka K., Ishizaka T. Human reaginic antibodies and immunoglobulin E. J Allergy. 1968 Dec;42(6):330–363. doi: 10.1016/0021-8707(68)90095-6. [DOI] [PubMed] [Google Scholar]
  5. Ishizaka K., Ishizaka T. Identification of gamma-E-antibodies as a carrier of reaginic activity. J Immunol. 1967 Dec;99(6):1187–1198. [PubMed] [Google Scholar]
  6. Kawashima H. [Study on the contaminating antigen in purified mumps virus antigen from the allantoic fluid of hen's eggs for enzyme-linked immunosorbent assay (ELISA)]. Kansenshogaku Zasshi. 1986 Mar;60(3):257–266. doi: 10.11150/kansenshogakuzasshi1970.60.257. [DOI] [PubMed] [Google Scholar]
  7. Parish W. E. Short-term anaphylactic IgG antibodies in human sera. Lancet. 1970 Sep 19;2(7673):591–592. doi: 10.1016/s0140-6736(70)90170-4. [DOI] [PubMed] [Google Scholar]
  8. Tsuji M., Sasaki K., Nakagawa M., Mori T., Nakayama T., Makino S., Okamura M. Improved enzyme-linked immunosorbent assay (ELISA) for the detection of mumps virus antibodies. Kitasato Arch Exp Med. 1983 Dec;56(4):137–147. [PubMed] [Google Scholar]
  9. Yamane N., Hiratsuka M., Arikawa J., Odagiri T., Ishida N. Antibody responses after repeated influenza A virus immunizations among schoolchildren in Japan. J Hyg (Lond) 1981 Dec;87(3):383–392. doi: 10.1017/s002217240006962x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Yamane N., Nakamura Y., Yuki M., Odagiri T., Ishida N. Serological evaluation of an influenza A virus cold-adapted reassortant live vaccine, CR-37 (H1N1), in Japanese adult volunteers. J Hyg (Lond) 1984 Apr;92(2):231–242. doi: 10.1017/s0022172400064251. [DOI] [PMC free article] [PubMed] [Google Scholar]

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