Skip to main content
PMC home page
Epidemiology and Infection logoLink to Epidemiology and Infection
. 1988 Oct;101(2):269–278. doi: 10.1017/s0950268800054182

The characterization and pathological significance of gastric Campylobacter-like organisms in the ferret: a model for chronic gastritis?

D S Tompkins 1, J I Wyatt 1, B J Rathbone 1, A P West 1
PMCID: PMC2249373  PMID: 3181311

Abstract

Gastric campylobacter-like organisms (CLO) were isolated from gastric tissues removed at sacrifice from 17 mature ferrets; all animals were colonized, but no macroscopic mucosal lesions or histological features of chronic gastritis were seen. The isolates resembled Campylobacter pylori in many cultural and biochemical characteristics, and produced substantial urease activity, but there were sufficient differences from C. pylori to suggest that ferret gastric CLO represents a separate species. Comparison of human C. pylori and ferret gastric CLO may help to elucidate the pathogenicity of the former in patients with gastritis, and the ferret may serve as a useful animal model for the study of C. pylori infection.

Full text

PDF
269

Images in this article

272Fig. 1
on p.272
273Fig. 2
on p.273
275Fig. 3
on p.275

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bolton F. J., Holt A. V., Hutchinson D. N. Urease-positive thermophilic campylobacters. Lancet. 1985 May 25;1(8439):1217–1218. doi: 10.1016/s0140-6736(85)92898-3. [DOI] [PubMed] [Google Scholar]
  2. Fox J. G., Edrise B. M., Cabot E. B., Beaucage C., Murphy J. C., Prostak K. S. Campylobacter-like organisms isolated from gastric mucosa of ferrets. Am J Vet Res. 1986 Feb;47(2):236–239. [PubMed] [Google Scholar]
  3. Giannella R. A., Broitman S. A., Zamcheck N. Gastric acid barrier to ingested microorganisms in man: studies in vivo and in vitro. Gut. 1972 Apr;13(4):251–256. doi: 10.1136/gut.13.4.251. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Goodwin C. S., Armstrong J. A., Marshall B. J. Campylobacter pyloridis, gastritis, and peptic ulceration. J Clin Pathol. 1986 Apr;39(4):353–365. doi: 10.1136/jcp.39.4.353. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Goodwin C. S., Blincow E. D., Warren J. R., Waters T. E., Sanderson C. R., Easton L. Evaluation of cultural techniques for isolating Campylobacter pyloridis from endoscopic biopsies of gastric mucosa. J Clin Pathol. 1985 Oct;38(10):1127–1131. doi: 10.1136/jcp.38.10.1127. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Goodwin C. S., McCulloch R. K., Armstrong J. A., Wee S. H. Unusual cellular fatty acids and distinctive ultrastructure in a new spiral bacterium (Campylobacter pyloridis) from the human gastric mucosa. J Med Microbiol. 1985 Apr;19(2):257–267. doi: 10.1099/00222615-19-2-257. [DOI] [PubMed] [Google Scholar]
  7. Gray S. F., Wyatt J. I., Rathbone B. J. Simplified techniques for identifying Campylobacter pyloridis. J Clin Pathol. 1986 Nov;39(11):1279–1279. doi: 10.1136/jcp.39.11.1279-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hazell S. L., Lee A. Campylobacter pyloridis, urease, hydrogen ion back diffusion, and gastric ulcers. Lancet. 1986 Jul 5;2(8497):15–17. doi: 10.1016/s0140-6736(86)92561-4. [DOI] [PubMed] [Google Scholar]
  9. Laemmli U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970 Aug 15;227(5259):680–685. doi: 10.1038/227680a0. [DOI] [PubMed] [Google Scholar]
  10. McNulty C. A., Dent J. C. Rapid identification of Campylobacter pylori (C. pyloridis) by preformed enzymes. J Clin Microbiol. 1987 Sep;25(9):1683–1686. doi: 10.1128/jcm.25.9.1683-1686.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Megraud F., Bonnet F., Garnier M., Lamouliatte H. Characterization of "Campylobacter pyloridis" by culture, enzymatic profile, and protein content. J Clin Microbiol. 1985 Dec;22(6):1007–1010. doi: 10.1128/jcm.22.6.1007-1010.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Newell D. G., Hudson M. J., Baskerville A. Naturally occurring gastritis associated with Campylobacter pylori infection in the rhesus monkey. Lancet. 1987 Dec 5;2(8571):1338–1338. doi: 10.1016/s0140-6736(87)91236-0. [DOI] [PubMed] [Google Scholar]
  13. Rathbone B. J., Wyatt J. I., Heatley R. V. Campylobacter pyloridis--a new factor in peptic ulcer disease? Gut. 1986 Jun;27(6):635–641. doi: 10.1136/gut.27.6.635. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Rønne T. Measles virus infection without rash in childhood is related to disease in adult life. Lancet. 1985 Jan 5;1(8419):1–5. doi: 10.1016/s0140-6736(85)90961-4. [DOI] [PubMed] [Google Scholar]
  15. Tompkins D. S., West A. P. Campylobacter pylori, acid, and bile. J Clin Pathol. 1987 Nov;40(11):1387–1387. doi: 10.1136/jcp.40.11.1387-a. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Epidemiology and Infection are provided here courtesy of Cambridge University Press

RESOURCES