Skip to main content
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1968 Jun;60(2):713–720. doi: 10.1073/pnas.60.2.713

The mechanism and direction of RNA synthesis templated by free minus strands of a "little" variant of Q-beta RNA.

D R Mills, H L Bishop, S Spiegelman
PMCID: PMC225104  PMID: 5248825

Full text

PDF
713

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bishop D. H., Claybrook J. R., Pace N. R., Spiegelman S. An analysis by gel electrophoresis of Q-beta-RNA complexes formed during the latent period of an in vitro synthesis. Proc Natl Acad Sci U S A. 1967 May;57(5):1474–1481. doi: 10.1073/pnas.57.5.1474. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bishop D. H., Claybrook J. R., Spiegelman S. Electrophoretic separation of viral nucleic acids on polyacrylamide gels. J Mol Biol. 1967 Jun 28;26(3):373–387. doi: 10.1016/0022-2836(67)90310-5. [DOI] [PubMed] [Google Scholar]
  3. Bishop D. H., Pace N. R., Spiegelman S. The mechanism of replication: a novel polarity reversal in the in vitro synthesis of Q-beta-RNA and its complement. Proc Natl Acad Sci U S A. 1967 Oct;58(4):1790–1797. doi: 10.1073/pnas.58.4.1790. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Feix G., Pollet R., Weissmann C. Replication of viral RNA, XVI. Enzymatic synthesis of infectious virual RNA with noninfectious Q-beta minus strands as template. Proc Natl Acad Sci U S A. 1968 Jan;59(1):145–152. doi: 10.1073/pnas.59.1.145. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Francke B., Hofschneider P. H. Infectious nucleic acids of e. Coli bacteriophages, ix. Sedimentation constants and strand integrity of infectious m12 phage replicative-form RNA. Proc Natl Acad Sci U S A. 1966 Dec;56(6):1883–1890. doi: 10.1073/pnas.56.6.1883. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Franklin R. M. Purification and properties of the replicative intermediate of the RNA bacteriophage R17. Proc Natl Acad Sci U S A. 1966 Jun;55(6):1504–1511. doi: 10.1073/pnas.55.6.1504. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Haruna I., Spiegelman S. Specific template requirments of RNA replicases. Proc Natl Acad Sci U S A. 1965 Aug;54(2):579–587. doi: 10.1073/pnas.54.2.579. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Mills D. R., Pace N. R., Spiegelman S. The in vitro synthesis of a noninfectious complex containing biologically active viral RNA. Proc Natl Acad Sci U S A. 1966 Dec;56(6):1778–1785. doi: 10.1073/pnas.56.6.1778. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Mills D. R., Peterson R. L., Spiegelman S. An extracellular Darwinian experiment with a self-duplicating nucleic acid molecule. Proc Natl Acad Sci U S A. 1967 Jul;58(1):217–224. doi: 10.1073/pnas.58.1.217. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Pace N. R., Bishop D. H., Spiegelman S. Examination of the Qbeta-replicase reaction by sucrose gradient and gel electrophoresis. J Virol. 1967 Aug;1(4):771–778. doi: 10.1128/jvi.1.4.771-778.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Pace N. R., Bishop D. H., Spiegelman S. The immediate precursor of viral RNA in the Q-beta-repicase reaction. Proc Natl Acad Sci U S A. 1968 Jan;59(1):139–144. doi: 10.1073/pnas.59.1.139. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Pace N. R., Bishop D. H., Spiegelman S. The kinetics of product appearance and template involvement in the in vitro replication of viral RNA. Proc Natl Acad Sci U S A. 1967 Aug;58(2):711–718. doi: 10.1073/pnas.58.2.711. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Pace N. R., Spiegelman S. In vitro synthesis of an infectious mutant RNA with a normal RNA replicase. Science. 1966 Jul 1;153(3731):64–67. doi: 10.1126/science.153.3731.64. [DOI] [PubMed] [Google Scholar]
  14. Pace N. R., Spiegelman S. The synthesis of infectious RNA with a replicase purified according to its size and density. Proc Natl Acad Sci U S A. 1966 Jun;55(6):1608–1615. doi: 10.1073/pnas.55.6.1608. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Spiegelman S., Haruna I., Holland I. B., Beaudreau G., Mills D. The synthesis of a self-propagating and infectious nucleic acid with a purified enzyme. Proc Natl Acad Sci U S A. 1965 Sep;54(3):919–927. doi: 10.1073/pnas.54.3.919. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES