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. 2004;115:137–148.

Microbubbles and Ultrasound: A Bird's Eye View.

Sanjiv Kaul 1
PMCID: PMC2263759  PMID: 17060963

Abstract

Gas-filled microbubbles were initially used as ultrasound contrast agent because of their intravascular rheology, which is similar to that of red blood cells. Their transit through tissue can thus be quantified with ultrasound. More recently, these bubbles have been successfully used for molecular imaging by incorporating ligands on their surfaces that will adhere to cellular and other components within the microvasculature and can be detected by ultrasound. These bubbles have also been used for delivery of genes and drugs which can be released locally by disruption of the bubbles with high-energy ultrasound. Finally, bioeffects produced by localized ultrasound disruption of microbubbles have been shown to induce angiogenesis. This brief review will provide a bird's eye view of these applications.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Christiansen Jonathan P., Leong-Poi Howard, Klibanov Alexander L., Kaul Sanjiv, Lindner Jonathan R. Noninvasive imaging of myocardial reperfusion injury using leukocyte-targeted contrast echocardiography. Circulation. 2002 Apr 16;105(15):1764–1767. doi: 10.1161/01.cir.0000015466.89771.e2. [DOI] [PubMed] [Google Scholar]
  2. Dawson Dana, Vincent Michelle A., Barrett Eugene J., Kaul Sanjiv, Clark Andrew, Leong-Poi Howard, Lindner Jonathan R. Vascular recruitment in skeletal muscle during exercise and hyperinsulinemia assessed by contrast ultrasound. Am J Physiol Endocrinol Metab. 2002 Mar;282(3):E714–E720. doi: 10.1152/ajpendo.00373.2001. [DOI] [PubMed] [Google Scholar]
  3. Ellegala Dilantha B., Leong-Poi Howard, Carpenter Joan E., Klibanov Alexander L., Kaul Sanjiv, Shaffrey Mark E., Sklenar Jiri, Lindner Jonathan R. Imaging tumor angiogenesis with contrast ultrasound and microbubbles targeted to alpha(v)beta3. Circulation. 2003 Jun 30;108(3):336–341. doi: 10.1161/01.CIR.0000080326.15367.0C. [DOI] [PubMed] [Google Scholar]
  4. Fisher Nicholas G., Christiansen Jonathan P., Klibanov Alexander, Taylor Ronald P., Kaul Sanjiv, Lindner Jonathan R. Influence of microbubble surface charge on capillary transit and myocardial contrast enhancement. J Am Coll Cardiol. 2002 Aug 21;40(4):811–819. doi: 10.1016/s0735-1097(02)02038-7. [DOI] [PubMed] [Google Scholar]
  5. Jacobs A. K., Kelsey S. F., Brooks M. M., Faxon D. P., Chaitman B. R., Bittner V., Mock M. B., Weiner B. H., Dean L., Winston C. Better outcome for women compared with men undergoing coronary revascularization: a report from the bypass angioplasty revascularization investigation (BARI) Circulation. 1998 Sep 29;98(13):1279–1285. doi: 10.1161/01.cir.98.13.1279. [DOI] [PubMed] [Google Scholar]
  6. Jayaweera A. R., Edwards N., Glasheen W. P., Villanueva F. S., Abbott R. D., Kaul S. In vivo myocardial kinetics of air-filled albumin microbubbles during myocardial contrast echocardiography. Comparison with radiolabeled red blood cells. Circ Res. 1994 Jun;74(6):1157–1165. doi: 10.1161/01.res.74.6.1157. [DOI] [PubMed] [Google Scholar]
  7. Kaul S., Jayaweera A. R. Coronary and myocardial blood volumes: noninvasive tools to assess the coronary microcirculation? Circulation. 1997 Aug 5;96(3):719–724. [PubMed] [Google Scholar]
  8. Kaul S., Senior R., Dittrich H., Raval U., Khattar R., Lahiri A. Detection of coronary artery disease with myocardial contrast echocardiography: comparison with 99mTc-sestamibi single-photon emission computed tomography. Circulation. 1997 Aug 5;96(3):785–792. [PubMed] [Google Scholar]
  9. Keller M. W., Segal S. S., Kaul S., Duling B. The behavior of sonicated albumin microbubbles within the microcirculation: a basis for their use during myocardial contrast echocardiography. Circ Res. 1989 Aug;65(2):458–467. doi: 10.1161/01.res.65.2.458. [DOI] [PubMed] [Google Scholar]
  10. Leong-Poi H., Le E., Rim S. J., Sakuma T., Kaul S., Wei K. Quantification of myocardial perfusion and determination of coronary stenosis severity during hyperemia using real-time myocardial contrast echocardiography. J Am Soc Echocardiogr. 2001 Dec;14(12):1173–1182. doi: 10.1067/mje.2001.115982. [DOI] [PubMed] [Google Scholar]
  11. Leong-Poi Howard, Christiansen Jonathan, Klibanov Alexander L., Kaul Sanjiv, Lindner Jonathan R. Noninvasive assessment of angiogenesis by ultrasound and microbubbles targeted to alpha(v)-integrins. Circulation. 2003 Jan 28;107(3):455–460. doi: 10.1161/01.cir.0000044916.05919.8b. [DOI] [PubMed] [Google Scholar]
  12. Lepper Wolfgang, Nowak Bernd, Franke Andreas, Schröder Jörg, Janssens Uwe, Kaul Sanjiv, Buell Udalrich, Hanrath Peter, Hoffmann Rainer. Myocardial contrast echocardiography, single-photon emission computed tomography, and regional function analysis for coronary stenosis description during vasodilator stress. Am J Cardiol. 2003 Feb 15;91(4):445–448. doi: 10.1016/s0002-9149(02)03243-5. [DOI] [PubMed] [Google Scholar]
  13. Lindner J. R., Song J., Xu F., Klibanov A. L., Singbartl K., Ley K., Kaul S. Noninvasive ultrasound imaging of inflammation using microbubbles targeted to activated leukocytes. Circulation. 2000 Nov 28;102(22):2745–2750. doi: 10.1161/01.cir.102.22.2745. [DOI] [PubMed] [Google Scholar]
  14. Lindner J. R., Villanueva F. S., Dent J. M., Wei K., Sklenar J., Kaul S. Assessment of resting perfusion with myocardial contrast echocardiography: theoretical and practical considerations. Am Heart J. 2000 Feb;139(2 Pt 1):231–240. [PubMed] [Google Scholar]
  15. Ragosta M., Camarano G., Kaul S., Powers E. R., Sarembock I. J., Gimple L. W. Microvascular integrity indicates myocellular viability in patients with recent myocardial infarction. New insights using myocardial contrast echocardiography. Circulation. 1994 Jun;89(6):2562–2569. doi: 10.1161/01.cir.89.6.2562. [DOI] [PubMed] [Google Scholar]
  16. Rim S. J., Leong-Poi H., Lindner J. R., Couture D., Ellegala D., Mason H., Durieux M., Kassel N. F., Kaul S. Quantification of cerebral perfusion with "Real-Time" contrast-enhanced ultrasound. Circulation. 2001 Nov 20;104(21):2582–2587. doi: 10.1161/hc4601.099400. [DOI] [PubMed] [Google Scholar]
  17. Sabia P. J., Powers E. R., Jayaweera A. R., Ragosta M., Kaul S. Functional significance of collateral blood flow in patients with recent acute myocardial infarction. A study using myocardial contrast echocardiography. Circulation. 1992 Jun;85(6):2080–2089. doi: 10.1161/01.cir.85.6.2080. [DOI] [PubMed] [Google Scholar]
  18. Sabia P. J., Powers E. R., Ragosta M., Sarembock I. J., Burwell L. R., Kaul S. An association between collateral blood flow and myocardial viability in patients with recent myocardial infarction. N Engl J Med. 1992 Dec 24;327(26):1825–1831. doi: 10.1056/NEJM199212243272601. [DOI] [PubMed] [Google Scholar]
  19. Senior R., Kaul S., Soman P., Lahiri A. Power doppler harmonic imaging: a feasibility study of a new technique for the assessment of myocardial perfusion. Am Heart J. 2000 Feb;139(2 Pt 1):245–251. doi: 10.1067/mhj.2000.101488. [DOI] [PubMed] [Google Scholar]
  20. Skyba D. M., Price R. J., Linka A. Z., Skalak T. C., Kaul S. Direct in vivo visualization of intravascular destruction of microbubbles by ultrasound and its local effects on tissue. Circulation. 1998 Jul 28;98(4):290–293. doi: 10.1161/01.cir.98.4.290. [DOI] [PubMed] [Google Scholar]
  21. Song Ji, Qi Ming, Kaul Sanjiv, Price Richard J. Stimulation of arteriogenesis in skeletal muscle by microbubble destruction with ultrasound. Circulation. 2002 Sep 17;106(12):1550–1555. doi: 10.1161/01.cir.0000028810.33423.95. [DOI] [PubMed] [Google Scholar]
  22. Wei K., Jayaweera A. R., Firoozan S., Linka A., Skyba D. M., Kaul S. Quantification of myocardial blood flow with ultrasound-induced destruction of microbubbles administered as a constant venous infusion. Circulation. 1998 Feb 10;97(5):473–483. doi: 10.1161/01.cir.97.5.473. [DOI] [PubMed] [Google Scholar]
  23. Wei K., Le E., Bin J. P., Coggins M., Thorpe J., Kaul S. Quantification of renal blood flow with contrast-enhanced ultrasound. J Am Coll Cardiol. 2001 Mar 15;37(4):1135–1140. doi: 10.1016/s0735-1097(00)01210-9. [DOI] [PubMed] [Google Scholar]

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