Table 3.
Characteristics of the different carbachol-evoked responses
| Iout | Muscarinic receptor reponse | ||||
|---|---|---|---|---|---|
| Iout+↑ sPSCs | ↑ sPSCs | ↓sPSCs | |||
| Iout | Peak amplitude (pA) | 7.2±1.1 (n=20) | 7.0±0.8 (n=18) | – | – |
| Duration (s) | 81.3±7.3 (n=20) | 88.8±7.3 (n=18) | – | – | |
| Latency (s) | 22.7 ± 1.5 (n=20) | 22.6±1.5 (n=17) | – | – | |
| ↑sPSCs | Peak frequency change (%) | – | 43.0±4.6 (n=11) | 64.3±9.5 (n=6) | – |
| Duration (s) | – | 81.5±7.8 (n=7) | 85.6±14.8 (n=6) | – | |
| Latency (s) | – | 28.5±2.6 (n=9) | 28.1±2.3 (n=6) | – | |
| ↓sPSCs | Peak frequency change (%) | – | – | – | −45.5±11.8 (n=5) |
| Duration (s) | – | – | – | 67.0±15.5 (n=5) | |
| Latency (s) | – | – | – | 27.4±2.3 (n=5) | |
Abbreviations: Iout, outward current; sPSCs, spontaneous postsynaptic currents. –, not applicable.