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Sensitivity of HIV-1 R5 envelopes to reagents that interfere with gp120:CD4 interactions. Pseudovirions carrying envelopes encoded by envelope genes amplified from patient samples were tested for sensitivity to inhibition by (A) anti-CD4 mab, Q4120, (B) sCD4, (C) PRO 542 and (D) BMS-378806. Macrophage-tropic envelopes (light symbols) were more sensitive to sCD4 and PRO 542 compared to non-macrophage-tropic envelopes (dark symbols) but were more resistant to the anti-CD4 mab, Q4120.
