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. 2008 Jan 18;5:5. doi: 10.1186/1742-4690-5-5

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Copyright © 2008 Peters et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Sensitivity of HIV-1 R5 envelopes to reagents that interfere with gp120:CCR5 interactions. Pseudovirions carrying envelopes encoded by envelope genes amplified from patient samples were tested for sensitivity to inhibition by (A) TAK779, (B) SCH350581 and (C) anti-CCR5, 2D7. Macrophage-tropic envelopes (light symbols) and non-macrophage-tropic envelopes (dark symbols) were examined. Statistical analysis showed no overall correlation between macrophage-tropism and sensitivity to TAK779 or SCH350581 (Table 2).