. 2008 Jan 18;5:5. doi: 10.1186/1742-4690-5-5

Table 2.

Non-parametric two-tailed Spearman analysis for correlations between R5 envelope macrophage-tropism and sensitivity to entry inhibitors.

Inhibitor/Antibody	Target of reagent	Stage of entry blocked³.	Correlation with Macrophage-tropism (p Values)
Q4120	CD4	env: CD4 interactions	<0.0001**
sCD4	gp120, CD4bs	env: CD4 interactions	<0.0001**
PRO 542 (IgG-CD4)	gp120, CD4bs	env: CD4 interactions	<0.0001**
BMS-378806	gp120, CD4bs channel¹.	env: CD4 interactions	0.0002**
b12	gp120, overlapping CD4bs².		0.6843
TAK779	CCR5	env: CCR5 interactions	0.7964
SCH350581	CCR5	env: CCR5 interactions	0.7587
2D7	CCR5	env: CCR5 interactions
2G12	gp120 glycan	env: CCR5 interactions	0.0138*
T20	gp41 conformational changes	gp41 conformational changes	0.7061
2F5	gp41 membrane proximal region	gp41 conformational changes⁴.	0.3741
4E10	gp41 membrane proximal region	gp41 conformational changes⁴.	0.3502

1. BMS-378806 binds to a hydrophobic channel deep in the channel targeted by CD4 [42].

2. Mab b12 binds an epitope that overlaps the CD4bs [57].

3. Mab 2G12 binds to a glycan on gp120. 2G12 blocks env:CCR5 interactions but may also block earlier stages of entry [73].

4. Mabs 2F5 and 4E10 block gp41 conformational changes but may also block earlier stages of entry [73].

* Significant (p ≤ 0.05).

** Highly significant (p ≤ 0.01)