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. 1994 Dec;113(3):529–536. doi: 10.1017/s0950268800068540

Hepatitis C virus infection in Iceland: a recently introduced blood-borne disease.

A Löve 1, B Stanzeit 1
PMCID: PMC2271308  PMID: 7527781

Abstract

This study demonstrates a very high prevalence of antibodies to hepatitis C virus among Icelandic intravenous (i.v.) drug users. Of 152 identified i.v. drug users 95 (63%) were shown to have antibodies to the hepatitis C virus. In contrast the seroprevalence in the general Icelandic population is low, (0.2%). Almost all cases of hepatitis C virus infection in Iceland are due to i.v. drug use or to use of infected blood or blood products. Sporadic cases with unexplained modes of transmission, a significant portion of hepatitis C infections elsewhere, are virtually non-existent in Iceland. The results of this study are consistent with the hypothesis that the sporadic community-acquired cases could be caused by blood transfer due to bites from insect vectors such as mosquitoes which are not found in Iceland.

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Selected References

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  1. Alter M. J., Coleman P. J., Alexander W. J., Kramer E., Miller J. K., Mandel E., Hadler S. C., Margolis H. S. Importance of heterosexual activity in the transmission of hepatitis B and non-A, non-B hepatitis. JAMA. 1989 Sep 1;262(9):1201–1205. [PubMed] [Google Scholar]
  2. Alter M. J., Margolis H. S., Krawczynski K., Judson F. N., Mares A., Alexander W. J., Hu P. Y., Miller J. K., Gerber M. A., Sampliner R. E. The natural history of community-acquired hepatitis C in the United States. The Sentinel Counties Chronic non-A, non-B Hepatitis Study Team. N Engl J Med. 1992 Dec 31;327(27):1899–1905. doi: 10.1056/NEJM199212313272702. [DOI] [PubMed] [Google Scholar]
  3. Bortolotti F., Tagger A., Cadrobbi P., Crivellaro C., Pregliasco F., Ribero M. L., Alberti A. Antibodies to hepatitis C virus in community-acquired acute non-A, non-B hepatitis. J Hepatol. 1991 Mar;12(2):176–180. doi: 10.1016/0168-8278(91)90935-5. [DOI] [PubMed] [Google Scholar]
  4. Bresters D., Mauser-Bunschoten E. P., Reesink H. W., Roosendaal G., van der Poel C. L., Chamuleau R. A., Jansen P. L., Weegink C. J., Cuypers H. T., Lelie P. N. Sexual transmission of hepatitis C virus. Lancet. 1993 Jul 24;342(8865):210–211. doi: 10.1016/0140-6736(93)92300-i. [DOI] [PubMed] [Google Scholar]
  5. Brettler D. B., Mannucci P. M., Gringeri A., Rasko J. E., Forsberg A. D., Rumi M. G., Garsia R. J., Rickard K. A., Colombo M. The low risk of hepatitis C virus transmission among sexual partners of hepatitis C-infected hemophilic males: an international, multicenter study. Blood. 1992 Jul 15;80(2):540–543. [PubMed] [Google Scholar]
  6. Choo Q. L., Kuo G., Weiner A. J., Overby L. R., Bradley D. W., Houghton M. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science. 1989 Apr 21;244(4902):359–362. doi: 10.1126/science.2523562. [DOI] [PubMed] [Google Scholar]
  7. Everhart J. E., Di Bisceglie A. M., Murray L. M., Alter H. J., Melpolder J. J., Kuo G., Hoofnagle J. H. Risk for non-A, non-B (type C) hepatitis through sexual or household contact with chronic carriers. Ann Intern Med. 1990 Apr 1;112(7):544–545. doi: 10.7326/0003-4819-112-7-544. [DOI] [PubMed] [Google Scholar]
  8. Garson J. A., Tedder R. S., Briggs M., Tuke P., Glazebrook J. A., Trute A., Parker D., Barbara J. A., Contreras M., Aloysius S. Detection of hepatitis C viral sequences in blood donations by "nested" polymerase chain reaction and prediction of infectivity. Lancet. 1990 Jun 16;335(8703):1419–1422. doi: 10.1016/0140-6736(90)91446-h. [DOI] [PubMed] [Google Scholar]
  9. Gordon S. C., Patel A. H., Kulesza G. W., Barnes R. E., Silverman A. L. Lack of evidence for the heterosexual transmission of hepatitis C. Am J Gastroenterol. 1992 Dec;87(12):1849–1851. [PubMed] [Google Scholar]
  10. Hollinger F. B., Lin H. J. Community-acquired hepatitis C virus infection. Gastroenterology. 1992 Apr;102(4 Pt 1):1426–1429. doi: 10.1016/0016-5085(92)90791-v. [DOI] [PubMed] [Google Scholar]
  11. Houghton M., Weiner A., Han J., Kuo G., Choo Q. L. Molecular biology of the hepatitis C viruses: implications for diagnosis, development and control of viral disease. Hepatology. 1991 Aug;14(2):381–388. [PubMed] [Google Scholar]
  12. Janot C., Couroucé A. M., Maniez M. Antibodies to hepatitis C virus in French blood donors. Lancet. 1989 Sep 30;2(8666):796–797. doi: 10.1016/s0140-6736(89)90851-9. [DOI] [PubMed] [Google Scholar]
  13. Kaneko S., Unoura M., Kobayashi K., Kuno K., Murakami S., Hattori N. Detection of serum hepatitis C virus RNA. Lancet. 1990 Apr 21;335(8695):976–976. doi: 10.1016/0140-6736(90)91042-9. [DOI] [PubMed] [Google Scholar]
  14. Kühnl P., Seidl S., Stangel W., Beyer J., Sibrowski W., Flik J. Antibody to hepatitis C virus in German blood donors. Lancet. 1989 Aug 5;2(8658):324–324. doi: 10.1016/s0140-6736(89)90500-x. [DOI] [PubMed] [Google Scholar]
  15. Novati R., Thiers V., Monforte A. D., Maisonneuve P., Principi N., Conti M., Lazzarin A., Brechot C. Mother-to-child transmission of hepatitis C virus detected by nested polymerase chain reaction. J Infect Dis. 1992 Apr;165(4):720–723. doi: 10.1093/infdis/165.4.720. [DOI] [PubMed] [Google Scholar]
  16. Reinus J. F., Leikin E. L., Alter H. J., Cheung L., Shindo M., Jett B., Piazza S., Shih J. W. Failure to detect vertical transmission of hepatitis C virus. Ann Intern Med. 1992 Dec 1;117(11):881–886. doi: 10.7326/0003-4819-117-11-881. [DOI] [PubMed] [Google Scholar]
  17. Roggendorf M., Deinhardt F., Rasshofer R., Eberle J., Hopf U., Möller B., Zachoval R., Pape G., Schramm W., Rommel F. Antibodies to hepatitis C virus. Lancet. 1989 Aug 5;2(8658):324–325. doi: 10.1016/s0140-6736(89)90501-1. [DOI] [PubMed] [Google Scholar]
  18. Sirchia G., Bellobuono A., Giovanetti A., Marconi M. Antibodies to hepatitis C virus in Italian blood donors. Lancet. 1989 Sep 30;2(8666):797–797. doi: 10.1016/s0140-6736(89)90852-0. [DOI] [PubMed] [Google Scholar]
  19. Stevens C. E., Taylor P. E., Pindyck J., Choo Q. L., Bradley D. W., Kuo G., Houghton M. Epidemiology of hepatitis C virus. A preliminary study in volunteer blood donors. JAMA. 1990 Jan 5;263(1):49–53. [PubMed] [Google Scholar]
  20. Transmission of hepatitis C virus. Ann Intern Med. 1990 Sep 1;113(5):411–412. doi: 10.7326/0003-4819-113-5-411. [DOI] [PubMed] [Google Scholar]
  21. Van der Poel C. L., Cuypers H. T., Reesink H. W., Weiner A. J., Quan S., Di Nello R., Van Boven J. J., Winkel I., Mulder-Folkerts D., Exel-Oehlers P. J. Confirmation of hepatitis C virus infection by new four-antigen recombinant immunoblot assay. Lancet. 1991 Feb 9;337(8737):317–319. doi: 10.1016/0140-6736(91)90942-i. [DOI] [PubMed] [Google Scholar]
  22. Verbaan H., Widell A., Lindgren S., Lindmark B., Nordenfelt E., Eriksson S. Hepatitis C in chronic liver disease: an epidemiological study based on 566 consecutive patients undergoing liver biopsy during a 10-year period. J Intern Med. 1992 Jul;232(1):33–42. doi: 10.1111/j.1365-2796.1992.tb00547.x. [DOI] [PubMed] [Google Scholar]
  23. Watanabe J., Minegishi K., Mitsumori T., Ishifuji M., Oguchi T., Ueda M., Tokunaga E., Tanaka E., Kiyosawa K., Furuta S. Prevalence of anti-HCV antibody in blood donors in the Tokyo area. Vox Sang. 1990;59(2):86–88. doi: 10.1111/j.1423-0410.1990.tb05015.x. [DOI] [PubMed] [Google Scholar]
  24. Weiner A. J., Kuo G., Bradley D. W., Bonino F., Saracco G., Lee C., Rosenblatt J., Choo Q. L., Houghton M. Detection of hepatitis C viral sequences in non-A, non-B hepatitis. Lancet. 1990 Jan 6;335(8680):1–3. doi: 10.1016/0140-6736(90)90134-q. [DOI] [PubMed] [Google Scholar]
  25. Wejstål R., Hermodsson S., Iwarson S., Norkrans G. Mother to infant transmission of hepatitis C virus infection. J Med Virol. 1990 Mar;30(3):178–180. doi: 10.1002/jmv.1890300306. [DOI] [PubMed] [Google Scholar]
  26. White T. J., Madej R., Persing D. H. The polymerase chain reaction: clinical applications. Adv Clin Chem. 1992;29:161–196. doi: 10.1016/s0065-2423(08)60224-3. [DOI] [PubMed] [Google Scholar]

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