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. 1994 Feb;112(1):13–23. doi: 10.1017/s095026880005737x

Dose-response effects in an outbreak of Salmonella enteritidis.

E D Mintz 1, M L Cartter 1, J L Hadler 1, J T Wassell 1, J A Zingeser 1, R V Tauxe 1
PMCID: PMC2271488  PMID: 8119352

Abstract

The effects of ingested Salmonella enteritidis (SE) dose on incubation period and on the severity and duration of illness were estimated in a cohort of 169 persons who developed gastroenteritis after eating hollandaise sauce made from grade-A shell eggs. The cohort was divided into three groups based on self-reported dose of sauce ingested. As dose increased, median incubation period decreased (37 h in the low exposure group v. 21 h in the medium exposure group v. 17.5 h in the high exposure group, P = 0.006) and greater proportions reported body aches (71 v. 85 v. 94%, P = 0.0009) and vomiting (21 v. 56 v. 57%, P = 0.002). Among 118 case-persons who completed a follow-up questionnaire, increased dose was associated with increases in median weight loss in kilograms (3.2 v. 4.5 v. 5.0, P = 0.0001), maximum daily number of stools (12.5 v. 15.0 v. 20.0, P = 0.02), subjective rating of illness severity (P = 0.0007), and the number of days of confinement to bed (3.0 v. 6.5 v. 6.5, P = 0.04). In this outbreak, ingested dose was an important determinant of the incubation period, symptoms and severity of acute salmonellosis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blaser M. J., Newman L. S. A review of human salmonellosis: I. Infective dose. Rev Infect Dis. 1982 Nov-Dec;4(6):1096–1106. doi: 10.1093/clinids/4.6.1096. [DOI] [PubMed] [Google Scholar]
  2. Centers for Disease Control (CDC) Outbreak of Salmonella enteritidis infection associated with consumption of raw shell eggs, 1991. MMWR Morb Mortal Wkly Rep. 1992 May 29;41(21):369–372. [PubMed] [Google Scholar]
  3. Centers for Disease Control (CDC) Update: Salmonella enteritidis infections and shell eggs--United States, 1990. MMWR Morb Mortal Wkly Rep. 1990 Dec 21;39(50):909–912. [PubMed] [Google Scholar]
  4. Craven P. C., Mackel D. C., Baine W. B., Barker W. H., Gangarosa E. J. International outbreak of Salmonella Eastbourne infection traced to contaminated chocolate. Lancet. 1975 Apr 5;1(7910):788–792. doi: 10.1016/s0140-6736(75)92446-0. [DOI] [PubMed] [Google Scholar]
  5. Fontaine R. E., Cohen M. L., Martin W. T., Vernon T. M. Epidemic salmonellosis from cheddar cheese: surveillance and prevention. Am J Epidemiol. 1980 Feb;111(2):247–253. doi: 10.1093/oxfordjournals.aje.a112892. [DOI] [PubMed] [Google Scholar]
  6. Glynn J. R., Palmer S. R. Incubation period, severity of disease, and infecting dose: evidence from a Salmonella outbreak. Am J Epidemiol. 1992 Dec 1;136(11):1369–1377. doi: 10.1093/oxfordjournals.aje.a116449. [DOI] [PubMed] [Google Scholar]
  7. Hornick R. B., Greisman S. E., Woodward T. E., DuPont H. L., Dawkins A. T., Snyder M. J. Typhoid fever: pathogenesis and immunologic control. N Engl J Med. 1970 Sep 24;283(13):686–691. doi: 10.1056/NEJM197009242831306. [DOI] [PubMed] [Google Scholar]
  8. McCULLOUGH N. B., EISELE C. W. Experimental human salmonellosis. I. Pathogenicity of strains of Salmonella meleagridis and Salmonella anatum obtained from spray-dried whole egg. J Infect Dis. 1951 May-Jun;88(3):278–289. doi: 10.1093/infdis/88.3.278. [DOI] [PubMed] [Google Scholar]
  9. McCULLOUGH N. B., EISELE C. W. Experimental human salmonellosis. III. Pathogenicity of strains of Salmonella newport, Salmonella derby, and Salmonella bareilly obtained from spray-dried whole egg. J Infect Dis. 1951 Nov-Dec;89(3):209–213. doi: 10.1093/infdis/89.3.209. [DOI] [PubMed] [Google Scholar]
  10. McCULLOUGH N., EISELE C. W. Experimental human salmonellosis. IV. Pathogenicity of strains of Salmonella pullorum obtained from spray-dried whole egg. J Infect Dis. 1951 Nov-Dec;89(3):259–265. doi: 10.1093/infdis/89.3.259. [DOI] [PubMed] [Google Scholar]
  11. Mishu B., Griffin P. M., Tauxe R. V., Cameron D. N., Hutcheson R. H., Schaffner W. Salmonella enteritidis gastroenteritis transmitted by intact chicken eggs. Ann Intern Med. 1991 Aug 1;115(3):190–194. doi: 10.7326/0003-4819-115-3-190. [DOI] [PubMed] [Google Scholar]
  12. Rodrigue D. C., Tauxe R. V., Rowe B. International increase in Salmonella enteritidis: a new pandemic? Epidemiol Infect. 1990 Aug;105(1):21–27. doi: 10.1017/s0950268800047609. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Ward L. R., de Sa J. D., Rowe B. A phage-typing scheme for Salmonella enteritidis. Epidemiol Infect. 1987 Oct;99(2):291–294. doi: 10.1017/s0950268800067765. [DOI] [PMC free article] [PubMed] [Google Scholar]

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