Abstract
An outbreak of measles occurred in a community school and the surrounding area in Crowborough, East Sussex, UK, from December 1992 to February 1993. There were 96 suspected cases reported: 66 cases among 1673 students at one school and 30 community cases. The majority of suspected cases were in those aged 11-17 (78%), 2 cases occurred in infants < 1 year old and 8 cases in adults aged 18 years or over. Data collected on 60 (91%) of the 66 suspect school cases showed 56 (93%) had an illness which met a case definition of measles. Eighteen had confirmatory IgM measles antibody. Two cases were hospitalized. The local percentage uptake for measles immunization for the school age years affected varied between 64% and 84%. A survey of parents showed that approximately 74% of the students attending the school had a history of measles immunization. The immunization rates reported by parents for children who developed measles was 21%, (29% based on GP records) compared with 77% for those who remained well. Vaccine efficacy was estimated to be 92%. This outbreak, along with others recently reported in older unimmunized children in the UK, reinforces the need for catch-up immunization programmes to reach this susceptible group of adolescents.
Full text
PDFImages in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Birkhead G. S., Morse D. L., Mills I. J., Novick L. F. New York State's two-dose schedule for measles immunization. Public Health Rep. 1991 May-Jun;106(3):338–344. [PMC free article] [PubMed] [Google Scholar]
- Carter H., Gorman D. Measles outbreak in Fife: which MMR policy? Public Health. 1993 Jan;107(1):25–30. doi: 10.1016/s0033-3506(05)80489-5. [DOI] [PubMed] [Google Scholar]
- Carter H., Gorman D. Measles, mumps, and rubella vaccine: time for a two stage policy? BMJ. 1992 Mar 7;304(6827):637–637. doi: 10.1136/bmj.304.6827.637. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Centers for Disease Control (CDC) Classification of measles cases and categorization of measles elimination programs. MMWR Morb Mortal Wkly Rep. 1983 Jan 7;31(52):707–711. [PubMed] [Google Scholar]
- Cohen B. J., Mortimer P. P., Pereira M. S. Diagnostic assays with monoclonal antibodies for the human serum parvovirus-like virus (SPLV). J Hyg (Lond) 1983 Aug;91(1):113–130. doi: 10.1017/s0022172400060095. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Edmonson M. B., Addiss D. G., McPherson J. T., Berg J. L., Circo S. R., Davis J. P. Mild measles and secondary vaccine failure during a sustained outbreak in a highly vaccinated population. JAMA. 1990 May 9;263(18):2467–2471. [PubMed] [Google Scholar]
- Hill A. Measles, mumps, and rubella vaccination. BMJ. 1992 Mar 21;304(6829):779–779. doi: 10.1136/bmj.304.6829.779. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Markowitz L. E., Preblud S. R., Orenstein W. A., Rovira E. Z., Adams N. C., Hawkins C. E., Hinman A. R. Patterns of transmission in measles outbreaks in the United States, 1985-1986. N Engl J Med. 1989 Jan 12;320(2):75–81. doi: 10.1056/NEJM198901123200202. [DOI] [PubMed] [Google Scholar]
- Morgan-Capner P., Wright J., Miller C. L., Miller E. Surveillance of antibody to measles, mumps, and rubella by age. BMJ. 1988 Sep 24;297(6651):770–772. doi: 10.1136/bmj.297.6651.770. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Perry K. R., Brown D. W., Parry J. V., Panday S., Pipkin C., Richards A. Detection of measles, mumps, and rubella antibodies in saliva using antibody capture radioimmunoassay. J Med Virol. 1993 Jul;40(3):235–240. doi: 10.1002/jmv.1890400312. [DOI] [PubMed] [Google Scholar]