Abstract
During a prolonged outbreak of meningococcal disease caused by serogroup B serotype 15 sulphonamide-resistant strains in one British health district, there was considerable variation in attack rates by town. General practitioner (GP) antibiotic prescribing rates were compared in high and low incidence towns. The only significant difference found was that erythromycin prescribing was more frequent in the high incidence towns (rate ratio 4.0, 95% CI 3.2-4.8, in March 1987 and 3.0, 95% CI 2.4-3.7, in November 1987). This was probably due to increased GP consultation rates for upper respiratory tract infection (URTI), but higher erythromycin usage may have increased meningococcal acquisition rates or susceptibility to meningococcal disease. Antibiotic prescribing rates should be further investigated in defined areas of high and low incidence of meningococcal disease.
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Selected References
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- Cartwright K. A., Stuart J. M., Noah N. D. An outbreak of meningococcal disease in Gloucestershire. Lancet. 1986 Sep 6;2(8506):558–561. doi: 10.1016/s0140-6736(86)90124-8. [DOI] [PubMed] [Google Scholar]
- Filice G. A., Hayes P. S., Counts G. W., Griffiss J. M., Fraser D. W. Risk of group A meningococcal disease: bacterial interference and cross-reactive bacteria among mucosal flora. J Clin Microbiol. 1985 Aug;22(2):152–156. doi: 10.1128/jcm.22.2.152-156.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Krasinski K., Nelson J. D., Butler S., Luby J. P., Kusmiesz H. Possible association of mycoplasma and viral respiratory infections with bacterial meningitis. Am J Epidemiol. 1987 Mar;125(3):499–508. doi: 10.1093/oxfordjournals.aje.a114556. [DOI] [PubMed] [Google Scholar]
- Moore P. S., Hierholzer J., DeWitt W., Gouan K., Djoré D., Lippeveld T., Plikaytis B., Broome C. V. Respiratory viruses and mycoplasma as cofactors for epidemic group A meningococcal meningitis. JAMA. 1990 Sep 12;264(10):1271–1275. [PubMed] [Google Scholar]
- Olivares R., Hubert B. Clusters of meningococcal disease in France (1987-1988). Eur J Epidemiol. 1992 Sep;8(5):737–742. doi: 10.1007/BF00145393. [DOI] [PubMed] [Google Scholar]