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. 1990 Jun;104(3):397–404. doi: 10.1017/s0950268800047415

Bismuth subsalicylate in the prevention of colonization of infant mice with Campylobacter jejuni.

M L Hänninen 1
PMCID: PMC2271781  PMID: 2347383

Abstract

Infant mice were used for the evaluation of the efficacy of bismuth subsalicylate (BSS) in the prevention of the growth of Campylobacter jejuni in the intestine. The MIC90 of ten C. jejuni strains was 900 micrograms/ml. Of three dosage regimens tested, continuous treatment before and after the bacterial challenge, mimicking the way BSS is used in the prevention of traveller's diarrhoea, was the most effective. Growth inhibition was dose dependent; the high dose of 2000 micrograms per day was more effective than 300 micrograms per day. After cessation of treatment, campylobacter counts increased to the same level as in the control animals.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abimiku A. G., Dolby J. M., Borriello S. P. Comparison of different vaccines and induced immune response against Campylobacter jejuni colonization in the infant mouse. Epidemiol Infect. 1989 Apr;102(2):271–280. doi: 10.1017/s0950268800029940. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Armstrong J. A., Wee S. H., Goodwin C. S., Wilson D. H. Response of Campylobacter pyloridis to antibiotics, bismuth and an acid-reducing agent in vitro--an ultrastructural study. J Med Microbiol. 1987 Dec;24(4):343–350. doi: 10.1099/00222615-24-4-343. [DOI] [PubMed] [Google Scholar]
  3. Blaser M. J., Berkowitz I. D., LaForce F. M., Cravens J., Reller L. B., Wang W. L. Campylobacter enteritis: clinical and epidemiologic features. Ann Intern Med. 1979 Aug;91(2):179–185. doi: 10.7326/0003-4819-91-2-179. [DOI] [PubMed] [Google Scholar]
  4. Dolby J. M., Newell D. G. The protection of infant mice from colonization with Campylobacter jejuni by vaccination of the dams. J Hyg (Lond) 1986 Apr;96(2):143–151. doi: 10.1017/s0022172400065918. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. DuPont H. L., Sullivan P., Evans D. G., Pickering L. K., Evans D. J., Jr, Vollet J. J., Ericsson C. D., Ackerman P. B., Tjoa W. S. Prevention of traveler's diarrhea (emporiatric enteritis). Prophylactic administration of subsalicylate bismuth). JAMA. 1980 Jan 18;243(3):237–241. [PubMed] [Google Scholar]
  6. Field L. H., Underwood J. L., Pope L. M., Berry L. J. Intestinal colonization of neonatal animals by Campylobacter fetus subsp. jejuni. Infect Immun. 1981 Sep;33(3):884–892. doi: 10.1128/iai.33.3.884-892.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Gorbach S. L., Kean B. H., Evans D. G., Evans D. J., Jr, Bessudo D. Travelers' diarrhea and toxigenic Escherichia coli. N Engl J Med. 1975 May 1;292(18):933–936. doi: 10.1056/NEJM197505012921801. [DOI] [PubMed] [Google Scholar]
  8. Hänninen M. L. Effect of endotoxin on colonisation of Campylobacter jejuni in infant mice. J Med Microbiol. 1989 Nov;30(3):199–206. doi: 10.1099/00222615-30-3-199. [DOI] [PubMed] [Google Scholar]
  9. Lee A., O'Rourke J. L., Barrington P. J., Trust T. J. Mucus colonization as a determinant of pathogenicity in intestinal infection by Campylobacter jejuni: a mouse cecal model. Infect Immun. 1986 Feb;51(2):536–546. doi: 10.1128/iai.51.2.536-546.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Marshall B. J., Goodwin C. S., Warren J. R., Murray R., Blincow E. D., Blackbourn S. J., Phillips M., Waters T. E., Sanderson C. R. Prospective double-blind trial of duodenal ulcer relapse after eradication of Campylobacter pylori. Lancet. 1988 Dec 24;2(8626-8627):1437–1442. doi: 10.1016/s0140-6736(88)90929-4. [DOI] [PubMed] [Google Scholar]
  11. Pitkänen T. Travellers' diarrhoea caused by Campylobacter jejuni. Ann Clin Res. 1982 Apr;14(2):111–113. [PubMed] [Google Scholar]
  12. Steffen R., DuPont H. L., Heusser R., Helminger A., Witassek F., Manhart M. D., Schär M. Prevention of traveler's diarrhea by the tablet form of bismuth subsalicylate. Antimicrob Agents Chemother. 1986 Apr;29(4):625–627. doi: 10.1128/aac.29.4.625. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Svedhem A., Kaijser B. Campylobacter fetus subspecies jejuni: a common cause of diarrhea in Sweden. J Infect Dis. 1980 Sep;142(3):353–359. doi: 10.1093/infdis/142.3.353. [DOI] [PubMed] [Google Scholar]
  14. Walder M. Epidemiology of campylobacter enteritis. Scand J Infect Dis. 1982;14(1):27–33. doi: 10.3109/inf.1982.14.issue-1.06. [DOI] [PubMed] [Google Scholar]
  15. Walker R. I., Caldwell M. B., Lee E. C., Guerry P., Trust T. J., Ruiz-Palacios G. M. Pathophysiology of Campylobacter enteritis. Microbiol Rev. 1986 Mar;50(1):81–94. doi: 10.1128/mr.50.1.81-94.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]

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