Skip to main content
PMC home page
Epidemiology and Infection logoLink to Epidemiology and Infection
. 1991 Jun;106(3):513–521. doi: 10.1017/s0950268800067571

Effects of ceftriaxone on faecal flora: analysis by micromorphometry.

B C Meijer 1, G J Kootstra 1, D G Geertsma 1, M H Wilkinson 1
PMCID: PMC2271876  PMID: 2050206

Abstract

In order to elucidate the effect of ceftriaxone therapy on the morphology of gut microflora, 11 human volunteers were treated with ceftriaxone, 1 g daily, given intramuscularly in one dose. Treatment continued for 5 days. Faecal microflora was analysed by digital image processing before, during and after the treatment period. We derived simple numerical parameters which describe the morphologic composition of the flora. They were significantly influenced by the antibiotic, and returned to their baseline values more than 7 days after treatment was stopped. The procedure holds promise for clinical application.

Full text

PDF
513

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ambrose N. S., Johnson M., Burdon D. W., Keighley M. R. The influence of single dose intravenous antibiotics on faecal flora and emergence of Clostridium difficile. J Antimicrob Chemother. 1985 Mar;15(3):319–326. doi: 10.1093/jac/15.3.319. [DOI] [PubMed] [Google Scholar]
  2. Benno Y., Shiragami N., Uchida K., Yoshida T., Mitsuoka T. Effect of moxalactam on human fecal microflora. Antimicrob Agents Chemother. 1986 Jan;29(1):175–178. doi: 10.1128/aac.29.1.175. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Brumfitt W., Franklin I., Grady D., Hamilton-Miller J. M. Effect of amoxicillin-clavulanate and cephradine on the fecal flora of healthy volunteers not exposed to a hospital environment. Antimicrob Agents Chemother. 1986 Aug;30(2):335–337. doi: 10.1128/aac.30.2.335. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Goldstein E., Donovan R. M., Kim Y. Applications of computerized microscopic image analysis in infectious diseases. Rev Infect Dis. 1988 Jan-Feb;10(1):92–102. doi: 10.1093/clinids/10.1.92. [DOI] [PubMed] [Google Scholar]
  5. Høverstad T., Carlstedt-Duke B., Lingaas E., Norin E., Saxerholt H., Steinbakk M., Midtvedt T. Influence of oral intake of seven different antibiotics on faecal short-chain fatty acid excretion in healthy subjects. Scand J Gastroenterol. 1986 Oct;21(8):997–1003. doi: 10.3109/00365528608996411. [DOI] [PubMed] [Google Scholar]
  6. Meijer-Severs G. J., Joshi J. H. The effect of new broad-spectrum antibiotics on faecal flora of cancer patients. J Antimicrob Chemother. 1989 Oct;24(4):605–613. doi: 10.1093/jac/24.4.605. [DOI] [PubMed] [Google Scholar]
  7. Nord C. E., Bergan T., Thorsteinsson S. B. Impact of ticarcillin/clavulanate on the intestinal microflora. J Antimicrob Chemother. 1989 Nov;24 (Suppl B):221–226. doi: 10.1093/jac/24.suppl_b.221. [DOI] [PubMed] [Google Scholar]
  8. Singh A., Pyle B. H., McFeters G. A. Rapid enumeration of viable bacteria by image analysis. J Microbiol Methods. 1989;10:91–101. doi: 10.1016/0167-7012(89)90005-5. [DOI] [PubMed] [Google Scholar]
  9. van der Waaij D., Berghuis-de Vries J. M., Lekkerkerk Lekkerkerk-v Colonization resistance of the digestive tract in conventional and antibiotic-treated mice. J Hyg (Lond) 1971 Sep;69(3):405–411. doi: 10.1017/s0022172400021653. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Epidemiology and Infection are provided here courtesy of Cambridge University Press

RESOURCES