Skip to main content
PMC home page
Epidemiology and Infection logoLink to Epidemiology and Infection
. 1991 Apr;106(2):355–363. doi: 10.1017/s0950268800048500

Chronic atrophic oral candidiasis among patients with diabetes mellitus--role of secretor status.

F Z Aly 1, C C Blackwell 1, D A MacKenzie 1, D M Weir 1, R A Elton 1, C G Cumming 1, J A Sofaer 1, B F Clarke 1
PMCID: PMC2272001  PMID: 2019303

Abstract

Non-diabetic individuals who are non-secretors of blood group antigens are prone to superficial infections by Candida albicans. In this study, 216 patients with diabetes mellitus who were denture wearers were examined for the presence or absence of denture stomatitis. There was an overall trend for non-secretors to be prone to denture stomatitis compared with secretors. Stepwise linear discriminant analysis was used to dissect the contribution of secretor status and other variables to the development of the disease. Secretor status was found to be a contributory factor among patients with non-insulin dependent diabetes but not among those with insulin-dependent diabetes. The possible reasons for this are discussed.

Full text

PDF
355

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arendorf T. M., Walker D. M., Kingdom R. J., Roll J. R., Newcombe R. G. Tobacco smoking and denture wearing in oral candidal leukoplakia. Br Dent J. 1983 Nov 19;155(10):340–343. doi: 10.1038/sj.bdj.4805222. [DOI] [PubMed] [Google Scholar]
  2. Blackwell C. C., Aly F. Z., James V. S., Weir D. M., Collier A., Patrick A. W., Cumming C. G., Wray D., Clarke B. F. Blood group, secretor status and oral carriage of yeasts among patients with diabetes mellitus. Diabetes Res. 1989 Nov;12(3):101–104. [PubMed] [Google Scholar]
  3. Budtz-Jorgensen E., Bertram U. Denture stomatitis. I. The etiology in relation to trauma and infection. Acta Odontol Scand. 1970 Mar;28(1):71–92. doi: 10.3109/00016357009033133. [DOI] [PubMed] [Google Scholar]
  4. Budtz-Jörgensen E., Stenderup A., Grabowski M. An epidemiologic study of yeasts in elderly denture wearers. Community Dent Oral Epidemiol. 1975 May;3(3):115–119. doi: 10.1111/j.1600-0528.1975.tb00291.x. [DOI] [PubMed] [Google Scholar]
  5. Budtz-Jörgensen E. The significance of Candida albicans in denture stomatitis. Scand J Dent Res. 1974;82(2):151–190. doi: 10.1111/j.1600-0722.1974.tb00378.x. [DOI] [PubMed] [Google Scholar]
  6. Burford-Mason A. P., Weber J. C., Willoughby J. M. Oral carriage of Candida albicans, ABO blood group and secretor status in healthy subjects. J Med Vet Mycol. 1988 Feb;26(1):49–56. doi: 10.1080/02681218880000061. [DOI] [PubMed] [Google Scholar]
  7. Davenport J. C. The oral distribution of candida in denture stomatitis. Br Dent J. 1970 Aug 18;129(4):151–156. doi: 10.1038/sj.bdj.4802540. [DOI] [PubMed] [Google Scholar]
  8. Farman A. G. Atrophic lesions of the tongue: a prevalence study among 175 diabetic patients. J Oral Pathol. 1976 Sep;5(5):255–264. doi: 10.1111/j.1600-0714.1976.tb01774.x. [DOI] [PubMed] [Google Scholar]
  9. HALPERIN V., KOLAS S., JEFFERIS K. R., HUDDLESTON S. O., ROBINSON H. B. The occurrence of Fordyce spots, benign migratory glossitis, median rhomboid glossitis, and fissured tongue in 2,478 dental patients. Oral Surg Oral Med Oral Pathol. 1953 Sep;6(9):1072–1077. doi: 10.1016/0030-4220(53)90220-5. [DOI] [PubMed] [Google Scholar]
  10. Lamey P. J., Darwaza A., Fisher B. M., Samaranayake L. P., Macfarlane T. W., Frier B. M. Secretor status, candidal carriage and candidal infection in patients with diabetes mellitus. J Oral Pathol. 1988 Aug;17(7):354–357. doi: 10.1111/j.1600-0714.1988.tb01549.x. [DOI] [PubMed] [Google Scholar]
  11. Sharon A., Ben-Aryeh H., Itzhak B., Yoram K., Szargel R., Gutman D. Salivary composition in diabetic patients. J Oral Med. 1985 Jan-Mar;40(1):23–26. [PubMed] [Google Scholar]
  12. Thom S. M., Blackwell C. C., MacCallum C. J., Weir D. M., Brettle R. P., Kinane D. F., Wray D. Non-secretion of blood group antigens and susceptibility to infection by Candida species. FEMS Microbiol Immunol. 1989 Jun;1(6-7):401–405. doi: 10.1111/j.1574-6968.1989.tb02428.x. [DOI] [PubMed] [Google Scholar]
  13. Turrell A. J. Aetiology of inflamed upper denture-bearing tissues. Br Dent J. 1966 Jun 7;120(11):542–546. [PubMed] [Google Scholar]
  14. Vogt F. C. The incidence of oral candidiasis with use of inhaled corticosteroids. Ann Allergy. 1979 Oct;43(4):205–210. [PubMed] [Google Scholar]

Articles from Epidemiology and Infection are provided here courtesy of Cambridge University Press

RESOURCES