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. 1992 Jun;108(3):547–553. doi: 10.1017/s0950268800050044

Subacute sclerosing panencephalitis (SSPE) in Papua New Guinea: a high incidence in young children.

K M Lucas 1, R C Sanders 1, A Rongap 1, T Rongap 1, S Pinai 1, M P Alpers 1
PMCID: PMC2272203  PMID: 1601084

Abstract

Eighty-seven cases of subacute sclerosing panencephalitis (SSPE) were diagnosed from September 1988 to April 1991 in Papua New Guinea (PNG), by demonstration of high-titre measles-specific antibodies in cerebrospinal fluid (CSF). For 1990 the annual incidence of SSPE, for the study provinces, was calculated to be 56 cases per million under 20 years of age and it is expected that this figure will be higher in 1991. The mean age of presentation was 4.9 years, with a male to female ratio of 1.8:1. An elevation in the ratio of immunoglobulin G as a percentage of total protein in CSF and an increase in the CSF:serum immunoglobulin G ratio was shown in SSPE patients. The dramatic appearance and high frequency of the disease in PNG might relate to the early age of measles infection encountered in children in this country.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bradford M. M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976 May 7;72:248–254. doi: 10.1016/0003-2697(76)90527-3. [DOI] [PubMed] [Google Scholar]
  2. Cremer N. E., Cossen C. K., Shell G., Diggs J., Gallo D., Schmidt N. J. Enzyme immunoassay versus plaque neutralization and other methods for determination of immune status to measles and varicella-zoster viruses and versus complement fixation for serodiagnosis of infections with those viruses. J Clin Microbiol. 1985 Jun;21(6):869–874. doi: 10.1128/jcm.21.6.869-874.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Cutler R. W., Merler E., Hammerstad J. P. Production of antibody by the central nervous system in subacute sclerosing panencephalitis. Neurology. 1968 Jan;18(1 Pt 2):129–132. doi: 10.1212/wnl.18.1_part_2.129. [DOI] [PubMed] [Google Scholar]
  4. Dyken P. R., Swift A., DuRant R. H. Long-term follow-up of patients with subacute sclerosing panencephalitis treated with inosiplex. Ann Neurol. 1982 Apr;11(4):359–364. doi: 10.1002/ana.410110407. [DOI] [PubMed] [Google Scholar]
  5. Halsey N. A., Modlin J. F., Jabbour J. T., Dubey L., Eddins D. L., Ludwig D. D. Risk factors in subacute sclerosing panencephalitis: a case-control study. Am J Epidemiol. 1980 Apr;111(4):415–424. doi: 10.1093/oxfordjournals.aje.a112916. [DOI] [PubMed] [Google Scholar]
  6. Jabbour J. T., Duenas D. A., Sever J. L., Krebs H. M., Horta-Barbosa L. Epidemiology of subacute sclerosing panencephalitis (SSPE). A report of the SSPE registry. JAMA. 1972 May 15;220(7):959–962. [PubMed] [Google Scholar]
  7. Jabbour J. T., Garcia J. H., Lemmi H., Ragland J., Duenas D. A., Sever J. L. Subacute sclerosing panencephalitis. A multidisciplinary study of eight cases. JAMA. 1969 Mar 24;207(12):2248–2254. doi: 10.1001/jama.207.12.2248. [DOI] [PubMed] [Google Scholar]
  8. Mingioli E. S., Strober W., Tourtellotte W. W., Whitaker J. N., McFarlin D. E. Quantitation of IgG, IgA and IgM in the CSF by radioimmunoassay. Neurology. 1978 Oct;28(10):991–995. doi: 10.1212/wnl.28.10.991. [DOI] [PubMed] [Google Scholar]
  9. Modlin J. F., Halsey N. A., Eddins D. L., Conrad J. L., Jabbour J. T., Chien L., Robinson H. Epidemiology of subacute sclerosing panencephalitis. J Pediatr. 1979 Feb;94(2):231–236. doi: 10.1016/s0022-3476(79)80829-x. [DOI] [PubMed] [Google Scholar]
  10. Musher D. M., Luchi M. J., Watson D. A., Hamilton R., Baughn R. E. Pneumococcal polysaccharide vaccine in young adults and older bronchitics: determination of IgG responses by ELISA and the effect of adsorption of serum with non-type-specific cell wall polysaccharide. J Infect Dis. 1990 Apr;161(4):728–735. doi: 10.1093/infdis/161.4.728. [DOI] [PubMed] [Google Scholar]
  11. Nerenberg S. T., Prasad R., Rothman M. E. Cerebrospinal fluid IgG, IgA, IgM, IgD, and IgE levels in central nervous system disorders. Neurology. 1978 Oct;28(10):988–990. doi: 10.1212/wnl.28.10.988. [DOI] [PubMed] [Google Scholar]
  12. Risk W. S., Haddad F. S. The variable natural history of subacute sclerosing panencephalitis: a study of 118 cases from the Middle East. Arch Neurol. 1979 Oct;36(10):610–614. doi: 10.1001/archneur.1979.00500460044004. [DOI] [PubMed] [Google Scholar]
  13. Rittner C., Meier E. M., Stradmann B., Giles C. M., Köchling R., Mollenhauer E., Kreth H. W. Partial C4 deficiency in subacute sclerosing panencephalitis. Immunogenetics. 1984;20(4):407–415. doi: 10.1007/BF00345615. [DOI] [PubMed] [Google Scholar]
  14. Robbins S. J., Appleton B., Fiumara F., Burke C. Subacute sclerosing panencephalitis (SSPE): a report of 16 cases. Aust N Z J Med. 1984 Apr;14(2):126–130. doi: 10.1111/j.1445-5994.1984.tb04274.x. [DOI] [PubMed] [Google Scholar]
  15. Rogers S., Sanders R. C., Alpers M. P. Immunogenicity of standard dose Edmonston-Zagreb measles vaccine in highland Papua New Guinean children from four months of age. J Trop Med Hyg. 1991 Apr;94(2):88–91. [PubMed] [Google Scholar]
  16. Saha V., John T. J., Mukundan P., Gnanamuthu C., Prabhakar S., Arjundas G., Sayeed Z. A., Kumaresan G., Srinivas K. High incidence of subacute sclerosing panencephalitis in south India. Epidemiol Infect. 1990 Feb;104(1):151–156. doi: 10.1017/s0950268800054637. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Sanders R. C., Brian M., Rongap A., Watt P. D., Alpers M. P. High incidence of subacute sclerosing panencephalitis (SSPE) in young children in Papua New Guinea. Med J Aust. 1990 Dec 3;153(11-12):740–740. doi: 10.5694/j.1326-5377.1990.tb126355.x. [DOI] [PubMed] [Google Scholar]
  18. Sever J. L. Persistent measles infection of the central nervous system: subacute sclerosing panencephalitis. Rev Infect Dis. 1983 May-Jun;5(3):467–473. doi: 10.1093/clinids/5.3.467. [DOI] [PubMed] [Google Scholar]
  19. Soffer D., Rannon L., Alter M., Kahana E., Feldman S. Subacute sclerosing panencephalitis: an epidemiologic study in Israel. Am J Epidemiol. 1976 Jan;103(1):67–74. doi: 10.1093/oxfordjournals.aje.a112206. [DOI] [PubMed] [Google Scholar]
  20. Witt C. S., Alpers M. P. Impaired cell-mediated immunity in Papua New Guinean infants. P N G Med J. 1991 Jun;34(2):90–97. [PubMed] [Google Scholar]
  21. Zilber N., Rannon L., Alter M., Kahana E. Measles, measles vaccination, and risk of subacute sclerosing panencephalitis (SSPE). Neurology. 1983 Dec;33(12):1558–1564. [PubMed] [Google Scholar]

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