Abstract
A review of carbohydrates in metabolism is presented. The recent rash of books on diet and weight reduction implicate carbohydrates as the root cause of obesity and abnormal metabolism, but they actually play a positive role in normal metabolism. They are involved in energy metabolism, water balance and a host of other functions in the body. Used with intelligence and not with indulgence, they will continue to be good sources of calories, contributing to total nutritional health and well-being.
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Selected References
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- ALBRINK M. J., MEIGS J. W., MAN E. B. Serum lipids, hypertension and coronary artery disease. Am J Med. 1961 Jul;31:4–23. doi: 10.1016/0002-9343(61)90220-0. [DOI] [PubMed] [Google Scholar]
- Antar M. A. Studies of thrombus formation and fatty acid composition of serum lecithins and cephalins in man during high sugar and starch diets. J Atheroscler Res. 1968 May-Jun;8(3):569–578. doi: 10.1016/s0368-1319(68)80110-3. [DOI] [PubMed] [Google Scholar]
- BLOOM W. L. Inhibition of salt excretion by carbohydrate. Arch Intern Med. 1962 Jan;109:26–32. doi: 10.1001/archinte.1962.03620130028004. [DOI] [PubMed] [Google Scholar]
- Birchwood B. L., Little J. A., Antar M. A., Lucas C., Buckley G. C., Csima A., Kallos A. Interrelationship between the kinds of dietary carbohydrate and fat in hyperlipoproteinemic patients. 2. Sucrose and starch with mixed saturated and polyunsaturated fats. Atherosclerosis. 1970 Mar-Apr;11(2):183–190. doi: 10.1016/0021-9150(70)90056-0. [DOI] [PubMed] [Google Scholar]
- Bloom W. L., Azar G., Smith E. G., Jr Changes in heart size and plasma volume during fasting. Metabolism. 1966 May;15(5):409–413. doi: 10.1016/0026-0495(66)90081-3. [DOI] [PubMed] [Google Scholar]
- Bortz W. M., Wroldson A., Morris P., Issekutz B., Jr Fat, carbohydrate, salt, and weight loss. Am J Clin Nutr. 1967 Oct;20(10):1104–1112. doi: 10.1093/ajcn/20.10.1104. [DOI] [PubMed] [Google Scholar]
- Brunzell J. D., Lerner R. L., Hazzard W. R., Porte D., Jr, Bierman E. L. Improved glucose tolerance with high carbohydrate feeding in mild diabetes. N Engl J Med. 1971 Mar 11;284(10):521–524. doi: 10.1056/NEJM197103112841004. [DOI] [PubMed] [Google Scholar]
- CONN J. W., FAJANS S. S., SELTZER H. S. Spontaneous hypoglycemia as an early manifestation of diabetes mellitus. Diabetes. 1956 Nov-Dec;5(6):437–442. doi: 10.2337/diab.5.6.437. [DOI] [PubMed] [Google Scholar]
- Cahill G. F., Jr The Banting Memorial Lecture 1971. Physiology of insulin in man. Diabetes. 1971 Dec;20(12):785–799. doi: 10.2337/diab.20.12.785. [DOI] [PubMed] [Google Scholar]
- Flatt J. P., Blackburn G. L. The matabolic fuel regulatory system: implications for protein-sparing therapies during caloric deprivation and disease. Am J Clin Nutr. 1974 Feb;27(2):175–187. doi: 10.1093/ajcn/27.2.175. [DOI] [PubMed] [Google Scholar]
- Ford S., Jr, Bozian R. C., Knowles H. C., Jr Interactions of obesity, and glucose and insulin levels in hypertriglyceridemia. Am J Clin Nutr. 1968 Sep;21(9):904–910. doi: 10.1093/ajcn/21.9.904. [DOI] [PubMed] [Google Scholar]
- HERVEY G. R., McCANCE R. A. The effects of carbohydrate and sea water on the metabolism of men without food or sufficient water. Proc R Soc Lond B Biol Sci. 1952 Jul 10;139(897):527–545. doi: 10.1098/rspb.1952.0033. [DOI] [PubMed] [Google Scholar]
- Hermansen L., Hultman E., Saltin B. Muscle glycogen during prolonged severe exercise. Acta Physiol Scand. 1967 Oct-Nov;71(2):129–139. doi: 10.1111/j.1748-1716.1967.tb03719.x. [DOI] [PubMed] [Google Scholar]
- Hodges R. E., Krehl W. A. The role of carbohydrates in lipid metabolism. Am J Clin Nutr. 1965 Nov;17(5):334–346. doi: 10.1093/ajcn/17.5.334. [DOI] [PubMed] [Google Scholar]
- LOTSPEICH W. D. The role of insulin in the metabolism of amino acids. J Biol Chem. 1949 May;179(1):175–180. [PubMed] [Google Scholar]
- Lewis S., Gutin B. Nutrition and endurance. Am J Clin Nutr. 1973 Sep;26(9):1011–1014. doi: 10.1093/ajcn/26.9.1011. [DOI] [PubMed] [Google Scholar]
- MACDONALD L., BRAITHWAITE D. M. THE INFLUENCE OF DIETARY CARBOHYDRATES ON THE LIPID PATTERN IN SERUM AND IN ADIPOSE TISSUE. Clin Sci. 1964 Aug;27:23–30. [PubMed] [Google Scholar]
- Macdonald I., Roberts J. B. The serum lipid response of baboons to various carbohydrate meals. Metabolism. 1967 Jun;16(6):572–579. doi: 10.1016/0026-0495(67)90088-1. [DOI] [PubMed] [Google Scholar]
- Owen O. E., Morgan A. P., Kemp H. G., Sullivan J. M., Herrera M. G., Cahill G. F., Jr Brain metabolism during fasting. J Clin Invest. 1967 Oct;46(10):1589–1595. doi: 10.1172/JCI105650. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rickman F., Mitchell N., Dingman J., Dalen J. E. Changes in serum cholesterol during the Stillman diet. JAMA. 1974 Apr 1;228(1):54–58. [PubMed] [Google Scholar]
- STONE D. B., CONNOR W. E. The prolonged effects of a low cholesterol, high carbohydrate diet upon the serum lipids in diabetic patients. Diabetes. 1963 Mar-Apr;12:127–132. doi: 10.2337/diab.12.2.127. [DOI] [PubMed] [Google Scholar]
- Stock A. L., Yudkin J. Nutrient intake of subjects on low carbohydrate diet used in treatment of obesity. Am J Clin Nutr. 1970 Jul;23(7):948–952. doi: 10.1093/ajcn/23.7.948. [DOI] [PubMed] [Google Scholar]
- Swan D. C., Davidson P., Albrink M. J. Effect of simple and complex carbohydrates on plasma non-esterified fatty acids, plasma-sugar, and plasma-insulin during oral carbohydrate tolerance tests. Lancet. 1966 Jan 8;1(7428):60–63. doi: 10.1016/s0140-6736(66)92357-9. [DOI] [PubMed] [Google Scholar]
- WINITZ M., GRAFF J., SEEDMAN D. A. EFFECT OF DIETARY CARBOHYDRATE ON SERUM CHOLESTEROL LEVELS. Arch Biochem Biophys. 1964 Dec;108:576–579. doi: 10.1016/0003-9861(64)90446-1. [DOI] [PubMed] [Google Scholar]
- Weinsier R. L., Seeman A., Herrera M. G., Assal J. P., Soeldner J. S., Gleason R. E. High- and low-carbohydrate diets in diabetes mellitus. Study of effects on diabetic control, insulin secretion, and blood lipids. Ann Intern Med. 1974 Mar;80(3):332–341. doi: 10.7326/0003-4819-80-3-332. [DOI] [PubMed] [Google Scholar]
- Wool I. G., Stirewalt W. S., Kurihara K., Low R. B., Bailey P., Oyer D. Mode of action of insulin in the regulation of protein biosynthesis in muscle. Recent Prog Horm Res. 1968;24:139–213. doi: 10.1016/b978-1-4831-9827-9.50010-1. [DOI] [PubMed] [Google Scholar]
- YUDKIN J., CAREY M. The treatment of obesity by the "highfat" diet. The inevitability of calories. Lancet. 1960 Oct 29;2(7157):939–941. doi: 10.1016/s0140-6736(60)92019-5. [DOI] [PubMed] [Google Scholar]
- YUDKIN J. PATTERNS AND TRENDS IN CARBOHYDRATE CONSUMPTION AND THEIR RELATION TO DISEASE. Proc Nutr Soc. 1964;23:149–162. doi: 10.1079/pns19640028. [DOI] [PubMed] [Google Scholar]
- Yudkin J., Kakkar V. V., Szanto S. Sugar intake, serum insulin and platelet adhesiveness in men with and without peripheral vascular disease. Postgrad Med J. 1969 Sep;45(527):608–611. doi: 10.1136/pgmj.45.527.608. [DOI] [PMC free article] [PubMed] [Google Scholar]
