Abstract
The intestinal epithelium of the neonatal rat is a model system for the study of receptor-mediated endocytosis in which large amounts of IgG are transferred intact across polarized cells. This review summarizes the ultrastructural pathway followed by IgG during cellular transit and several important properties of the membrane receptor that recognizes the IgG.
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Selected References
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- Abrahamson D. R., Rodewald R. Evidence for the sorting of endocytic vesicle contents during the receptor-mediated transport of IgG across the newborn rat intestine. J Cell Biol. 1981 Oct;91(1):270–280. doi: 10.1083/jcb.91.1.270. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fechheimer M., Daiss J. L., Cebra J. J. Interaction of immunoglobulin with actin. Mol Immunol. 1979 Nov;16(11):881–888. doi: 10.1016/0161-5890(79)90086-5. [DOI] [PubMed] [Google Scholar]
- Goldstein J. L., Anderson R. G., Brown M. S. Coated pits, coated vesicles, and receptor-mediated endocytosis. Nature. 1979 Jun 21;279(5715):679–685. doi: 10.1038/279679a0. [DOI] [PubMed] [Google Scholar]
- Jersild R. A., Jr Restricted mobility and endocytosis of anionic sites on newborn rat jejunal brush border membranes. Anat Rec. 1982 Jan;202(1):61–71. doi: 10.1002/ar.1092020108. [DOI] [PubMed] [Google Scholar]
- Rodewald R., Abrahamson D. R. Receptor-mediated transport of IgG across the intestinal epithelium of the neonatal rat. Ciba Found Symp. 1982;(92):209–232. doi: 10.1002/9780470720745.ch11. [DOI] [PubMed] [Google Scholar]
- Rodewald R. Distribution of immunoglobulin G receptors in the small intestine of the young rat. J Cell Biol. 1980 Apr;85(1):18–32. doi: 10.1083/jcb.85.1.18. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rodewald R. Intestinal transport of antibodies in the newborn rat. J Cell Biol. 1973 Jul;58(1):189–211. doi: 10.1083/jcb.58.1.189. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rodewald R., Lewis D. M., Kraehenbuhl J. P. Immunoglobulin G receptors of intestinal brush borders from neonatal rats. Ciba Found Symp. 1983;95:287–299. doi: 10.1002/9780470720769.ch17. [DOI] [PubMed] [Google Scholar]
- Rodewald R., Newman S. B., Karnovsky M. J. Contraction of isolated brush borders from the intestinal epithelium. J Cell Biol. 1976 Sep;70(3):541–554. doi: 10.1083/jcb.70.3.541. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Steinman R. M., Mellman I. S., Muller W. A., Cohn Z. A. Endocytosis and the recycling of plasma membrane. J Cell Biol. 1983 Jan;96(1):1–27. doi: 10.1083/jcb.96.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Waldmann T. A., Jones E. A. The role of cell-surface receptors in the transport and catabolism of immunoglobulins. Ciba Found Symp. 1972;9:5–23. doi: 10.1002/9780470719923.ch2. [DOI] [PubMed] [Google Scholar]
- Wallace K. H., Rees A. R. Studies on the immunoglobulin-G Fc-fragment receptor from neonatal rat small intestine. Biochem J. 1980 Apr 15;188(1):9–16. doi: 10.1042/bj1880009. [DOI] [PMC free article] [PubMed] [Google Scholar]