Skip to main content
NCBI home page
The Journal of Cell Biology logoLink to The Journal of Cell Biology
. 1984 Jul 1;99(1 Pt 2):226s–231s. doi: 10.1083/jcb.99.1.226s

Postreceptor signal transduction by cyclic adenosine monophosphate and the Ca2+-calmodulin complex

A R Means, G R Slaughter, J A Putkey
PMCID: PMC2275604  PMID: 6086667

Full Text

The Full Text of this article is available as a PDF (854.4 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adelstein R. S., Conti M. A., Hathaway D. R., Klee C. B. Phosphorylation of smooth muscle myosin light chain kinase by the catalytic subunit of adenosine 3': 5'-monophosphate-dependent protein kinase. J Biol Chem. 1978 Dec 10;253(23):8347–8350. [PubMed] [Google Scholar]
  2. Andersen B., Osborn M., Weber K. Specific visualization of the distribution of the calcium dependent regulatory protein of cyclic nucleotide phosphodiesterase (modulator protein) in tissue culture cells by immunofluorescence microscopy: mitosis and intercellular bridge. Cytobiologie. 1978 Aug;17(2):354–364. [PubMed] [Google Scholar]
  3. Beale E. G., Dedman J. R., Means A. R. Isolation and characterization of a protein from rat testis which inhibits cyclic AMP-dependent protein kinase and phosdiesterase. J Biol Chem. 1977 Sep 25;252(18):6322–6327. [PubMed] [Google Scholar]
  4. Browne C. L., Lockwood A. H., Su J. L., Beavo J. A., Steiner A. L. Immunofluorescent localization of cyclic nucleotide-dependent protein kinases on the mitotic apparatus of cultured cells. J Cell Biol. 1980 Nov;87(2 Pt 1):336–345. doi: 10.1083/jcb.87.2.336. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Burridge K., Kelly T., Mangeat P. Nonerythrocyte spectrins: actin-membrane attachment proteins occurring in many cell types. J Cell Biol. 1982 Nov;95(2 Pt 1):478–486. doi: 10.1083/jcb.95.2.478. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Carlin R. K., Grab D. J., Siekevitz P. Function of a calmodulin in postsynaptic densities. III. Calmodulin-binding proteins of the postsynaptic density. J Cell Biol. 1981 Jun;89(3):449–455. doi: 10.1083/jcb.89.3.449. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Chafouleas J. G., Bolton W. E., Hidaka H., Boyd A. E., 3rd, Means A. R. Calmodulin and the cell cycle: involvement in regulation of cell-cycle progression. Cell. 1982 Jan;28(1):41–50. doi: 10.1016/0092-8674(82)90373-7. [DOI] [PubMed] [Google Scholar]
  8. Chafouleas J. G., Dedman J. R., Munjaal R. P., Means A. R. Calmodulin. Development and application of a sensitive radioimmunoassay. J Biol Chem. 1979 Oct 25;254(20):10262–10267. [PubMed] [Google Scholar]
  9. Chafouleas J. G., Lagacé L., Bolton W. E., Boyd A. E., 3rd, Means A. R. Changes in calmodulin and its mRNA accompany reentry of quiescent (G0) cells into the cell cycle. Cell. 1984 Jan;36(1):73–81. doi: 10.1016/0092-8674(84)90075-8. [DOI] [PubMed] [Google Scholar]
  10. Chafouleas J. G., Pardue R. L., Brinkley B. R., Dedman J. R., Means A. R. Regulation of intracellular levels of calmodulin and tubulin in normal and transformed cells. Proc Natl Acad Sci U S A. 1981 Feb;78(2):996–1000. doi: 10.1073/pnas.78.2.996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Chafouleas J. G., Riser M. E., Lagacé L., Means A. R. Production of polyclonal and monoclonal antibodies to calmodulin and utilization of these immunological probes. Methods Enzymol. 1983;102:104–110. doi: 10.1016/s0076-6879(83)02011-x. [DOI] [PubMed] [Google Scholar]
  12. Cochran B. H., Reffel A. C., Stiles C. D. Molecular cloning of gene sequences regulated by platelet-derived growth factor. Cell. 1983 Jul;33(3):939–947. doi: 10.1016/0092-8674(83)90037-5. [DOI] [PubMed] [Google Scholar]
  13. Cohen P. The role of protein phosphorylation in neural and hormonal control of cellular activity. Nature. 1982 Apr 15;296(5858):613–620. doi: 10.1038/296613a0. [DOI] [PubMed] [Google Scholar]
  14. Crouch T. H., Holroyde M. J., Collins J. H., Solaro R. J., Potter J. D. Interaction of calmodulin with skeletal muscle myosin light chain kinase. Biochemistry. 1981 Oct 27;20(22):6318–6325. doi: 10.1021/bi00525a006. [DOI] [PubMed] [Google Scholar]
  15. Dedman J. R., Potter J. D., Jackson R. L., Johnson J. D., Means A. R. Physicochemical properties of rat testis Ca2+-dependent regulator protein of cyclic nucleotide phosphodiesterase. Relationship of Ca2+-binding, conformational changes, and phosphodiesterase activity. J Biol Chem. 1977 Dec 10;252(23):8415–8422. [PubMed] [Google Scholar]
  16. Dedman J. R., Welsh M. J., Means A. R. Ca2+-dependent regulator. Production and characterization of a monospecific antibody. J Biol Chem. 1978 Oct 25;253(20):7515–7521. [PubMed] [Google Scholar]
  17. Deery W. J., Means A. R., Brinkley B. R. Calmodulin-microtubule association in cultured mammalian cells. J Cell Biol. 1984 Mar;98(3):904–910. doi: 10.1083/jcb.98.3.904. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Durkacz B. W., Shall S., Irwin J. The effect of inhibition of (ADP-ribose)n biosynthesis on DNA repair assayed by the nucleoid technique. Eur J Biochem. 1981 Dec;121(1):65–69. doi: 10.1111/j.1432-1033.1981.tb06430.x. [DOI] [PubMed] [Google Scholar]
  19. Ferraz C., Demaille J. G., Fisher E. H. The protein inhibitor of adenosine 3':5'-monophosphate-dependent protein kinases. Isolation and characterization of three isoinhibitors. Biochimie. 1979;61(5-6):645–651. doi: 10.1016/s0300-9084(79)80162-5. [DOI] [PubMed] [Google Scholar]
  20. Geisow M. J., Burgoyne R. D., Harris A. Interaction of calmodulin with adrenal chromaffin granule membranes. FEBS Lett. 1982 Jun 21;143(1):69–72. doi: 10.1016/0014-5793(82)80275-5. [DOI] [PubMed] [Google Scholar]
  21. Glenney J. R., Jr, Weber K. Calmodulin-binding proteins of the microfilaments present in isolated brush borders and microvilli of intestinal epithelial cells. J Biol Chem. 1980 Nov 25;255(22):10551–10554. [PubMed] [Google Scholar]
  22. Guerriero V., Jr, Rowley D. R., Means A. R. Production and characterization of an antibody to myosin light chain kinase and intracellular localization of the enzyme. Cell. 1981 Dec;27(3 Pt 2):449–458. doi: 10.1016/0092-8674(81)90386-x. [DOI] [PubMed] [Google Scholar]
  23. Jonak G. J., Baserga R. The cytoplasmic appearance of three functions expressed during the G0 leds to G1 leads to S transition is nucleus-dependent. J Cell Physiol. 1980 Nov;105(2):347–354. doi: 10.1002/jcp.1041050217. [DOI] [PubMed] [Google Scholar]
  24. Keith C., DiPaola M., Maxfield F. R., Shelanski M. L. Microinjection of Ca++-calmodulin causes a localized depolymerization of microtubules. J Cell Biol. 1983 Dec;97(6):1918–1924. doi: 10.1083/jcb.97.6.1918. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Klee C. B., Crouch T. H., Krinks M. H. Subunit structure and catalytic properties of bovine brain Ca2+-dependent cyclic nucleotide phosphodiesterase. Biochemistry. 1979 Feb 20;18(4):722–729. doi: 10.1021/bi00571a026. [DOI] [PubMed] [Google Scholar]
  26. Krebs E. G., Beavo J. A. Phosphorylation-dephosphorylation of enzymes. Annu Rev Biochem. 1979;48:923–959. doi: 10.1146/annurev.bi.48.070179.004423. [DOI] [PubMed] [Google Scholar]
  27. LaPorte D. C., Wierman B. M., Storm D. R. Calcium-induced exposure of a hydrophobic surface on calmodulin. Biochemistry. 1980 Aug 5;19(16):3814–3819. doi: 10.1021/bi00557a025. [DOI] [PubMed] [Google Scholar]
  28. Lagacé L., Chandra T., Woo S. L., Means A. R. Identification of multiple species of calmodulin messenger RNA using a full length complementary DNA. J Biol Chem. 1983 Feb 10;258(3):1684–1688. [PubMed] [Google Scholar]
  29. Marcum J. M., Dedman J. R., Brinkley B. R., Means A. R. Control of microtubule assembly-disassembly by calcium-dependent regulator protein. Proc Natl Acad Sci U S A. 1978 Aug;75(8):3771–3775. doi: 10.1073/pnas.75.8.3771. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. McPherson J. M., Whitehouse S., Walsh D. A. Possibility of shape conformers of the protein inhibitor of the cyclic adenosine monophosphate dependent protein kinase. Biochemistry. 1979 Oct 30;18(22):4835–4845. doi: 10.1021/bi00589a011. [DOI] [PubMed] [Google Scholar]
  31. Means A. R. Calmodulin: properties, intracellular localization, and multiple roles in cell regulation. Recent Prog Horm Res. 1981;37:333–367. doi: 10.1016/b978-0-12-571137-1.50011-6. [DOI] [PubMed] [Google Scholar]
  32. Means A. R., Dedman J. R. Calmodulin--an intracellular calcium receptor. Nature. 1980 May 8;285(5760):73–77. doi: 10.1038/285073a0. [DOI] [PubMed] [Google Scholar]
  33. Meyer F., Heilmeyer L. M., Jr, Haschke R. H., Fischer E. H. Control of phosphorylase activity in a muscle glycogen particle. I. Isolation and characterization of the protein-glycogen complex. J Biol Chem. 1970 Dec 25;245(24):6642–6648. [PubMed] [Google Scholar]
  34. Mita M., Price J. M., Hall P. F. Stimulation by follicle-stimulating hormone of synthesis of lactate by Sertoli cells from rat testis. Endocrinology. 1982 May;110(5):1535–1541. doi: 10.1210/endo-110-5-1535. [DOI] [PubMed] [Google Scholar]
  35. Munjaal R. P., Chandra T., Woo S. L., Dedman J. R., Means A. R. A cloned calmodulin structural gene probe is complementary to DNA sequences from diverse species. Proc Natl Acad Sci U S A. 1981 Apr;78(4):2330–2334. doi: 10.1073/pnas.78.4.2330. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Pledger W. J., Stiles C. D., Antoniades H. N., Scher C. D. Induction of DNA synthesis in BALB/c 3T3 cells by serum components: reevaluation of the commitment process. Proc Natl Acad Sci U S A. 1977 Oct;74(10):4481–4485. doi: 10.1073/pnas.74.10.4481. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Putkey J. A., Ts'ui K. F., Tanaka T., Lagacé L., Stein J. P., Lai E. C., Means A. R. Chicken calmodulin genes. A species comparison of cDNA sequences and isolation of a genomic clone. J Biol Chem. 1983 Oct 10;258(19):11864–11870. [PubMed] [Google Scholar]
  38. Riddle V. G., Pardee A. B. Quiescent cells but not cycling cells exhibit enhanced actin synthesis before they synthesize DNA. J Cell Physiol. 1980 Apr;103(1):11–15. doi: 10.1002/jcp.1041030103. [DOI] [PubMed] [Google Scholar]
  39. Robinson R., Fritz I. B. Metabolism of glucose by Sertoli cells in culture. Biol Reprod. 1981 Jun;24(5):1032–1041. doi: 10.1095/biolreprod24.5.1032. [DOI] [PubMed] [Google Scholar]
  40. Russell D. R., Bennett G. N. Construction and analysis of in vivo activity of E. coli promoter hybrids and promoter mutants that alter the -35 to -10 spacing. Gene. 1982 Dec;20(2):231–243. doi: 10.1016/0378-1119(82)90042-7. [DOI] [PubMed] [Google Scholar]
  41. Sittman D. B., Graves R. A., Marzluff W. F. Histone mRNA concentrations are regulated at the level of transcription and mRNA degradation. Proc Natl Acad Sci U S A. 1983 Apr;80(7):1849–1853. doi: 10.1073/pnas.80.7.1849. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. Slaughter G. R., Means A. R. Follicle-stimulating hormone activation of glycogen phosphorylase in the Sertoli cell-enriched rat testis. Endocrinology. 1983 Oct;113(4):1476–1485. doi: 10.1210/endo-113-4-1476. [DOI] [PubMed] [Google Scholar]
  43. Stein J. P., Munjaal R. P., Lagace L., Lai E. C., O'Malley B. W., Means A. R. Tissue-specific expression of a chicken calmodulin pseudogene lacking intervening sequences. Proc Natl Acad Sci U S A. 1983 Nov;80(21):6485–6489. doi: 10.1073/pnas.80.21.6485. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. Stiles C. D., Capone G. T., Scher C. D., Antoniades H. N., Van Wyk J. J., Pledger W. J. Dual control of cell growth by somatomedins and platelet-derived growth factor. Proc Natl Acad Sci U S A. 1979 Mar;76(3):1279–1283. doi: 10.1073/pnas.76.3.1279. [DOI] [PMC free article] [PubMed] [Google Scholar]
  45. Stiles C. D. The molecular biology of platelet-derived growth factor. Cell. 1983 Jul;33(3):653–655. doi: 10.1016/0092-8674(83)90008-9. [DOI] [PubMed] [Google Scholar]
  46. Stull J. T. Phosphorylation of contractile proteins in relation to muscle function. Adv Cyclic Nucleotide Res. 1980;13:39–93. [PubMed] [Google Scholar]
  47. Tanaka T., Hidaka H. Hydrophobic regions function in calmodulin-enzyme(s) interactions. J Biol Chem. 1980 Dec 10;255(23):11078–11080. [PubMed] [Google Scholar]
  48. Tash J. S., Means A. R. Regulation of protein phosphorylation and motility of sperm by cyclic adenosine monophosphate and calcium. Biol Reprod. 1982 May;26(4):745–763. doi: 10.1095/biolreprod26.4.745. [DOI] [PubMed] [Google Scholar]
  49. Tash J. S., Welsh M. J., Means A. R. Protein inhibitor of cAMP-dependent protein kinase: production and characterization of antibodies and intracellular localization. Cell. 1980 Aug;21(1):57–65. doi: 10.1016/0092-8674(80)90114-2. [DOI] [PubMed] [Google Scholar]
  50. Vieira J., Messing J. The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers. Gene. 1982 Oct;19(3):259–268. doi: 10.1016/0378-1119(82)90015-4. [DOI] [PubMed] [Google Scholar]
  51. Welsh M. J., Dedman J. R., Brinkley B. R., Means A. R. Calcium-dependent regulator protein: localization in mitotic apparatus of eukaryotic cells. Proc Natl Acad Sci U S A. 1978 Apr;75(4):1867–1871. doi: 10.1073/pnas.75.4.1867. [DOI] [PMC free article] [PubMed] [Google Scholar]
  52. Welsh M. J., Dedman J. R., Brinkley B. R., Means A. R. Tubulin and calmodulin. Effects of microtubule and microfilament inhibitors on localization in the mitotic apparatus. J Cell Biol. 1979 Jun;81(3):624–634. doi: 10.1083/jcb.81.3.624. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from The Journal of Cell Biology are provided here courtesy of The Rockefeller University Press

RESOURCES