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Developmental Immunology logoLink to Developmental Immunology
. 1992;2(1):1–6. doi: 10.1155/1992/28568

Changes in the Amphibian Antibody Repertoire are Correlated With Metamorphosis and not With Age or Size

Ellen Hsu 1, Louis Du Pasquier 2
PMCID: PMC2275844  PMID: 1521064

Abstract

Tadpole and adult Xenopus, manipulated to be of comparable size, exhibited stagespecific antibody expression. The production of adult-type higher-affinity anti-DNP antibodies proved to be independent of the age and size of the individual and is concomitant with the completion of metamorphosis. The appearance of new antibody specificities at such a time suggests that their expression occurs with the cell turnover and renewal during a period of morphological changes.

Keywords: Antibody repertoire, Xenopus, metamorphosis, amphibian

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