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. 1978;89:100–108.

Medicinal iron-induced hepatic cirrhosis: reversal by phlebotomy: studies on pathogenesis.

M S Wheby
PMCID: PMC2279425  PMID: 617015

Abstract

A patient with no underlying hematologic or iron metabolic disorder developed iron induced hepatic cirrhosis as a consequence of long term medicinal iron ingestion. Marked improvement in liver histology followed removal of 28 grams of iron by phlebotomy. Radioautographic studies in rats showed a periportal hepatocyte concentration of radioiron absorbed from the intestine while plasma transferrin was saturated. Based on these and other observations an hypothesis is proposed to explain liver damage in disorders of iron overload.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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