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. 1985;96:81–97.

The Gordon Wilson lecture. Monoclonal antibodies in human cancer.

H Koprowski
PMCID: PMC2279655  PMID: 6085705

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adams D. O., Hall T., Steplewski Z., Koprowski H. Tumors undergoing rejection induced by monoclonal antibodies of the IgG2a isotype contain increased numbers of macrophages activated for a distinctive form of antibody-dependent cytolysis. Proc Natl Acad Sci U S A. 1984 Jun;81(11):3506–3510. doi: 10.1073/pnas.81.11.3506. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Atkinson B. F., Ernst C. S., Herlyn M., Steplewski Z., Sears H. F., Koprowski H. Gastrointestinal cancer-associated antigen in immunoperoxidase assay. Cancer Res. 1982 Nov;42(11):4820–4823. [PubMed] [Google Scholar]
  3. Atkinson B., Ernst C. S., Ghrist B. F., Herlyn M., Blaszczyk M., Ross A. H., Herlyn D., Steplewski Z., Koprowski H. Identification of melanoma-associated antigens using fixed tissue screening of antibodies. Cancer Res. 1984 Jun;44(6):2577–2581. [PubMed] [Google Scholar]
  4. Blaszczyk M., Ross A. H., Ernst C. S., Marchisio M., Atkinson B. F., Pak K. Y., Steplewski Z., Koprowski H. A fetal glycolipid expressed on adenocarcinomas of the colon. Int J Cancer. 1984 Mar 15;33(3):313–318. doi: 10.1002/ijc.2910330307. [DOI] [PubMed] [Google Scholar]
  5. Chatal J. F., Saccavini J. C., Fumoleau P., Douillard J. Y., Curtet C., Kremer M., Le Mevel B., Koprowski H. Immunoscintigraphy of colon carcinoma. J Nucl Med. 1984 Mar;25(3):307–314. [PubMed] [Google Scholar]
  6. Doolittle R. F., Hunkapiller M. W., Hood L. E., Devare S. G., Robbins K. C., Aaronson S. A., Antoniades H. N. Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor. Science. 1983 Jul 15;221(4607):275–277. doi: 10.1126/science.6304883. [DOI] [PubMed] [Google Scholar]
  7. Downward J., Yarden Y., Mayes E., Scrace G., Totty N., Stockwell P., Ullrich A., Schlessinger J., Waterfield M. D. Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences. Nature. 1984 Feb 9;307(5951):521–527. doi: 10.1038/307521a0. [DOI] [PubMed] [Google Scholar]
  8. Engstrom P. F., MacIntyre J. M., Mittelman A., Klaassen D. J. Chemotherapy of advanced colorectal carcinoma: fluorouracil alone vs. two drug combinations using fluorouracil, hydroxyurea, semustine, dacarbazine, razoxane, and mitomycin. A phase III trial by the Eastern Cooperative Oncology Group (EST: 1278). Am J Clin Oncol. 1984 Aug;7(4):313–318. [PubMed] [Google Scholar]
  9. Ernst C., Atkinson B., Wysocka M., Blaszczyk M., Herlyn M., Sears H., Steplewski Z., Koprowski H. Monoclonal antibody localization of Lewis antigens in fixed tissue. Lab Invest. 1984 Apr;50(4):394–400. [PubMed] [Google Scholar]
  10. Gudjonsson B., Livstone E. M., Spiro H. M. Cancer of the pancreas: diagnostic accuracy and survival statistics. Cancer. 1978 Nov;42(5):2494–2506. doi: 10.1002/1097-0142(197811)42:5<2494::aid-cncr2820420554>3.0.co;2-r. [DOI] [PubMed] [Google Scholar]
  11. Herlyn D. M., Steplewski Z., Herlyn M. F., Koprowski H. Inhibition of growth of colorectal carcinoma in nude mice by monoclonal antibody. Cancer Res. 1980 Mar;40(3):717–721. [PubMed] [Google Scholar]
  12. Herlyn D., Herlyn M., Steplewski Z., Koprowski H. Monoclonal antibodies in cell-mediated cytotoxicity against human melanoma and colorectal carcinoma. Eur J Immunol. 1979 Aug;9(8):657–659. doi: 10.1002/eji.1830090817. [DOI] [PubMed] [Google Scholar]
  13. Herlyn D., Koprowski H. IgG2a monoclonal antibodies inhibit human tumor growth through interaction with effector cells. Proc Natl Acad Sci U S A. 1982 Aug;79(15):4761–4765. doi: 10.1073/pnas.79.15.4761. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Herlyn M., Herlyn D., Elder D. E., Bondi E., LaRossa D., Hamilton R., Sears H. F., Balaban G., Guerry D., 4th, Clark W. H. Phenotypic characteristics of cells derived from precursors of human melanoma. Cancer Res. 1983 Nov;43(11):5502–5508. [PubMed] [Google Scholar]
  15. Herlyn M., Sears H. F., Steplewski Z., Koprowski H. Monoclonal antibody detection of a circulating tumor-associated antigen. I. Presence of antigen in sera of patients with colorectal, gastric, and pancreatic carcinoma. J Clin Immunol. 1982 Apr;2(2):135–140. doi: 10.1007/BF00916897. [DOI] [PubMed] [Google Scholar]
  16. Herlyn M., Shen J. W., Sears H. F., Civin C. I., Verrill H. L., Goldberg E. M., Koprowski H. Detection of a circulating gastrointestinal cancer antigen in sera of patients with gastrointestinal malignancies by a double determinant immunoassay with monoclonal antibodies against human blood group determinants. Clin Exp Immunol. 1984 Jan;55(1):23–35. [PMC free article] [PubMed] [Google Scholar]
  17. Herlyn M., Steplewski Z., Herlyn D., Clark W. H., Jr, Ross A. H., Blaszczyk M., Pak K. Y., Koprowski H. Production and characterization of monoclonal antibodies against human malignant melanoma. Cancer Invest. 1983;1(3):215–224. doi: 10.3109/07357908309041361. [DOI] [PubMed] [Google Scholar]
  18. Koprowski H., Herlyn D., Lubeck M., DeFreitas E., Sears H. F. Human anti-idiotype antibodies in cancer patients: Is the modulation of the immune response beneficial for the patient? Proc Natl Acad Sci U S A. 1984 Jan;81(1):216–219. doi: 10.1073/pnas.81.1.216. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Koprowski H., Steplewski Z., Herlyn D., Herlyn M. Study of antibodies against human melanoma produced by somatic cell hybrids. Proc Natl Acad Sci U S A. 1978 Jul;75(7):3405–3409. doi: 10.1073/pnas.75.7.3405. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Limas C., Lange P., Fraley E. E., Vessella R. L. A, B, H antigens in transitional cell tumors of the urinary bladder: correlation with the clinical course. Cancer. 1979 Dec;44(6):2099–2107. doi: 10.1002/1097-0142(197912)44:6<2099::aid-cncr2820440621>3.0.co;2-i. [DOI] [PubMed] [Google Scholar]
  21. Mach J. P., Chatal J. F., Lumbroso J. D., Buchegger F., Forni M., Ritschard J., Berche C., Douillard J. Y., Carrel S., Herlyn M. Tumor localization in patients by radiolabeled monoclonal antibodies against colon carcinoma. Cancer Res. 1983 Nov;43(11):5593–5600. [PubMed] [Google Scholar]
  22. Magnani J. L., Nilsson B., Brockhaus M., Zopf D., Steplewski Z., Koprowski H., Ginsburg V. A monoclonal antibody-defined antigen associated with gastrointestinal cancer is a ganglioside containing sialylated lacto-N-fucopentaose II. J Biol Chem. 1982 Dec 10;257(23):14365–14369. [PubMed] [Google Scholar]
  23. Mitchell K. F., Ward F. E., Koprowski H. DR antigens on melanoma cells: analysis with monoclonal antibodies. Hum Immunol. 1982 Feb;4(1):15–26. doi: 10.1016/0198-8859(82)90046-5. [DOI] [PubMed] [Google Scholar]
  24. Moertel C. G., Childs D. S., Jr, Reitemeier R. J., Colby M. Y., Jr, Holbrook M. A. Combined 5-fluorouracil and supervoltage radiation therapy of locally unresectable gastrointestinal cancer. Lancet. 1969 Oct 25;2(7626):865–867. doi: 10.1016/s0140-6736(69)92326-5. [DOI] [PubMed] [Google Scholar]
  25. Moldofsky P. J., Sears H. F., Mulhern C. B., Jr, Hammond N. D., Powe J., Gatenby R. A., Steplewski Z., Koprowski H. Detection of metastatic tumor in normal-sized retroperitoneal lymph nodes by monoclonal-antibody imaging. N Engl J Med. 1984 Jul 12;311(2):106–107. doi: 10.1056/NEJM198407123110207. [DOI] [PubMed] [Google Scholar]
  26. Olding L. B., Thurin J., Svalander C., Koprowski H. Expression of gastrointestinal carcinoma-associated antigen (GICA) detected in human fetal tissues by monoclonal antibody NS-19-9. Int J Cancer. 1984 Aug 15;34(2):187–192. doi: 10.1002/ijc.2910340208. [DOI] [PubMed] [Google Scholar]
  27. Ritz J., Schlossman S. F. Utilization of monoclonal antibodies in the treatment of leukemia and lymphoma. Blood. 1982 Jan;59(1):1–11. [PubMed] [Google Scholar]
  28. Ross A. H., Grob P., Bothwell M., Elder D. E., Ernst C. S., Marano N., Ghrist B. F., Slemp C. C., Herlyn M., Atkinson B. Characterization of nerve growth factor receptor in neural crest tumors using monoclonal antibodies. Proc Natl Acad Sci U S A. 1984 Nov;81(21):6681–6685. doi: 10.1073/pnas.81.21.6681. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Sears H. F., Atkinson B., Mattis J., Ernst C., Herlyn D., Steplewski Z., Häyry P., Koprowski H. Phase-I clinical trial of monoclonal antibody in treatment of gastrointestinal tumours. Lancet. 1982 Apr 3;1(8275):762–765. doi: 10.1016/s0140-6736(82)91811-6. [DOI] [PubMed] [Google Scholar]
  30. Sears H. F., Herlyn D., Steplewski Z., Koprowski H. Effects of monoclonal antibody immunotherapy on patients with gastrointestinal adenocarcinoma. J Biol Response Mod. 1984;3(2):138–150. [PubMed] [Google Scholar]
  31. Steplewski Z., Herlyn D., Maul G., Koprowski H. Hypothesis: macrophages as effector cells for human tumor destruction mediated by monoclonal antibody. Hybridoma. 1983;2(1):1–5. doi: 10.1089/hyb.1983.2.1. [DOI] [PubMed] [Google Scholar]
  32. Steplewski Z., Lubeck M. D., Koprowski H. Human macrophages armed with murine immunoglobulin G2a antibodies to tumors destroy human cancer cells. Science. 1983 Aug 26;221(4613):865–867. doi: 10.1126/science.6879183. [DOI] [PubMed] [Google Scholar]

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