Abstract
We report a case of disseminated infection with Aspergillus granulosus in a cardiac transplant recipient on immunosuppressive therapy. This is the first reported case in which this organism has been described as a pathogen. This organism bears morphological features different from those of more common Aspergillus species and should be considered a potential pathogen in immunocompromised patients.
Full Text
The Full Text of this article is available as a PDF (311.2 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Allo M. D., Miller J., Townsend T., Tan C. Primary cutaneous aspergillosis associated with Hickman intravenous catheters. N Engl J Med. 1987 Oct 29;317(18):1105–1108. doi: 10.1056/NEJM198710293171802. [DOI] [PubMed] [Google Scholar]
- Bodey G. P., Vartivarian S. Aspergillosis. Eur J Clin Microbiol Infect Dis. 1989 May;8(5):413–437. doi: 10.1007/BF01964057. [DOI] [PubMed] [Google Scholar]
- Böhler K., Metze D., Poitschek C., Jurecka W. Cutaneous aspergillosis. Clin Exp Dermatol. 1990 Nov;15(6):446–450. doi: 10.1111/j.1365-2230.1990.tb02141.x. [DOI] [PubMed] [Google Scholar]
- Diamond R. D., Krzesicki R., Epstein B., Jao W. Damage to hyphal forms of fungi by human leukocytes in vitro. A possible host defense mechanism in aspergillosis and mucormycosis. Am J Pathol. 1978 May;91(2):313–328. [PMC free article] [PubMed] [Google Scholar]
- Googe P. B., DeCoste S. D., Herold W. H., Mihm M. C., Jr Primary cutaneous aspergillosis mimicking dermatophytosis. Arch Pathol Lab Med. 1989 Nov;113(11):1284–1286. [PubMed] [Google Scholar]
- Gurwith M. J., Stinson E. B., Remington J. S. Aspergillus infection complicating cardiac transplantation. Report of five cases. Arch Intern Med. 1971 Oct;128(4):541–545. [PubMed] [Google Scholar]
- Gustafson T. L., Schaffner W., Lavely G. B., Stratton C. W., Johnson H. K., Hutcheson R. H., Jr Invasive aspergillosis in renal transplant recipients: correlation with corticosteroid therapy. J Infect Dis. 1983 Aug;148(2):230–238. doi: 10.1093/infdis/148.2.230. [DOI] [PubMed] [Google Scholar]
- Hotchi M., Fujiwara M., Hata S., Nasu T. Chronic granulomatous disease associated with peculiar Aspergillus lesions. Patho-anatomical report based on two autopsy cases and a brief review of all autopsy cases reported in Japan. Virchows Arch A Pathol Anat Histol. 1980;387(1):1–15. doi: 10.1007/BF00428425. [DOI] [PubMed] [Google Scholar]
- Levitz S. M. Aspergillosis. Infect Dis Clin North Am. 1989 Mar;3(1):1–18. [PubMed] [Google Scholar]
- Loria K. M., Salinger M. H., Frohlich T. G., Gendelman M. D., Cook F. V., Arentzen C. E. Primary cutaneous aspergillosis in a heart transplant recipient treated with surgical excision and oral itraconazole. J Heart Lung Transplant. 1992 Jan-Feb;11(1 Pt 1):156–159. [PubMed] [Google Scholar]
- McCalmont T. H., Silverman J. F., Geisinger K. R. Cytologic diagnosis of aspergillosis in cardiac transplantation. Arch Surg. 1991 Mar;126(3):394–396. doi: 10.1001/archsurg.1991.01410270144022. [DOI] [PubMed] [Google Scholar]
- Rex J. H., Pfaller M. A., Rinaldi M. G., Polak A., Galgiani J. N. Antifungal susceptibility testing. Clin Microbiol Rev. 1993 Oct;6(4):367–381. doi: 10.1128/cmr.6.4.367. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rinaldi M. G. Invasive aspergillosis. Rev Infect Dis. 1983 Nov-Dec;5(6):1061–1077. doi: 10.1093/clinids/5.6.1061. [DOI] [PubMed] [Google Scholar]
- Schaffner A., Douglas H., Braude A. Selective protection against conidia by mononuclear and against mycelia by polymorphonuclear phagocytes in resistance to Aspergillus. Observations on these two lines of defense in vivo and in vitro with human and mouse phagocytes. J Clin Invest. 1982 Mar;69(3):617–631. doi: 10.1172/JCI110489. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Waldorf A. R., Levitz S. M., Diamond R. D. In vivo bronchoalveolar macrophage defense against Rhizopus oryzae and Aspergillus fumigatus. J Infect Dis. 1984 Nov;150(5):752–760. doi: 10.1093/infdis/150.5.752. [DOI] [PubMed] [Google Scholar]
- Watsky K. L., Eisen R. N., Bolognia J. L. Unilateral cutaneous emboli of Aspergillus. Arch Dermatol. 1990 Sep;126(9):1214–1217. [PubMed] [Google Scholar]
- Weiland D., Ferguson R. M., Peterson P. K., Snover D. C., Simmons R. L., Najarian J. S. Aspergillosis in 25 renal transplant patients. Epidemiology, clinical presentation, diagnosis, and management. Ann Surg. 1983 Nov;198(5):622–629. doi: 10.1097/00000658-198311000-00011. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Weston M. W. Invasive pulmonary aspergillosis in the early postcardiac transplantation period. Clin Cardiol. 1990 Jun;13(6):443–446. doi: 10.1002/clc.4960130614. [DOI] [PubMed] [Google Scholar]
- Zarabi M. C., Salmassi S. Antemortem diagnosis of systemic aspergillosis: ten-year review and report of a case. South Med J. 1984 May;77(5):584–588. doi: 10.1097/00007611-198405000-00011. [DOI] [PubMed] [Google Scholar]