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. 1987;98:21–28.

Regulation of fetal hemoglobin synthesis in sickle cell anemia.

D G Nathan
PMCID: PMC2279722  PMID: 2441510

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Antonarakis S. E., Boehm C. D., Giardina P. J., Kazazian H. H., Jr Nonrandom association of polymorphic restriction sites in the beta-globin gene cluster. Proc Natl Acad Sci U S A. 1982 Jan;79(1):137–141. doi: 10.1073/pnas.79.1.137. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Antonarakis S. E., Boehm C. D., Serjeant G. R., Theisen C. E., Dover G. J., Kazazian H. H., Jr Origin of the beta S-globin gene in blacks: the contribution of recurrent mutation or gene conversion or both. Proc Natl Acad Sci U S A. 1984 Feb;81(3):853–856. doi: 10.1073/pnas.81.3.853. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Benton W. D., Davis R. W. Screening lambdagt recombinant clones by hybridization to single plaques in situ. Science. 1977 Apr 8;196(4286):180–182. doi: 10.1126/science.322279. [DOI] [PubMed] [Google Scholar]
  4. Collins F. S., Metherall J. E., Yamakawa M., Pan J., Weissman S. M., Forget B. G. A point mutation in the A gamma-globin gene promoter in Greek hereditary persistence of fetal haemoglobin. Nature. 1985 Jan 24;313(6000):325–326. doi: 10.1038/313325a0. [DOI] [PubMed] [Google Scholar]
  5. Collins F. S., Stoeckert C. J., Jr, Serjeant G. R., Forget B. G., Weissman S. M. G gamma beta+ hereditary persistence of fetal hemoglobin: cosmid cloning and identification of a specific mutation 5' to the G gamma gene. Proc Natl Acad Sci U S A. 1984 Aug;81(15):4894–4898. doi: 10.1073/pnas.81.15.4894. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Gelinas R., Endlich B., Pfeiffer C., Yagi M., Stamatoyannopoulos G. G to A substitution in the distal CCAAT box of the A gamma-globin gene in Greek hereditary persistence of fetal haemoglobin. Nature. 1985 Jan 24;313(6000):323–325. doi: 10.1038/313323a0. [DOI] [PubMed] [Google Scholar]
  7. Gianni A. M., Bregni M., Cappellini M. D., Fiorelli G., Taramelli R., Giglioni B., Comi P., Ottolenghi S. A gene controlling fetal hemoglobin expression in adults is not linked to the non-alpha globin cluster. EMBO J. 1983;2(6):921–925. doi: 10.1002/j.1460-2075.1983.tb01522.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Giglioni B., Casini C., Mantovani R., Merli S., Comi P., Ottolenghi S., Saglio G., Camaschella C., Mazza U. A molecular study of a family with Greek hereditary persistence of fetal hemoglobin and beta-thalassemia. EMBO J. 1984 Nov;3(11):2641–2645. doi: 10.1002/j.1460-2075.1984.tb02187.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Gilman J. G., Harano T., Nakatsuji T., Bakioglu I., Reese A. L., Gardiner M. B., Huisman T. H. The ratio of the G gamma and A gamma chains: variations due to anomalies at the molecular level. Ann N Y Acad Sci. 1985;445:235–247. doi: 10.1111/j.1749-6632.1985.tb17193.x. [DOI] [PubMed] [Google Scholar]
  10. Gilman J. G., Huisman T. H. DNA sequence variation associated with elevated fetal G gamma globin production. Blood. 1985 Oct;66(4):783–787. [PubMed] [Google Scholar]
  11. Gilman J. G., Huisman T. H. Two independent genetic factors in the beta-globin gene cluster are associated with high G gamma-levels in the HbF of SS patients. Blood. 1984 Aug;64(2):452–457. [PubMed] [Google Scholar]
  12. Javid J., Pettis P. K., Miller J. E. Radio-ligand immunoassay for human hemoglobin variants. J Immunol Methods. 1981;41(2):247–255. doi: 10.1016/0022-1759(81)90247-7. [DOI] [PubMed] [Google Scholar]
  13. Labie D., Dunda-Belkhodja O., Rouabhi F., Pagnier J., Ragusa A., Nagel R. L. The -158 site 5' to the G gamma gene and G gamma expression. Blood. 1985 Dec;66(6):1463–1465. [PubMed] [Google Scholar]
  14. Labie D., Pagnier J., Lapoumeroulie C., Rouabhi F., Dunda-Belkhodja O., Chardin P., Beldjord C., Wajcman H., Fabry M. E., Nagel R. L. Common haplotype dependency of high G gamma-globin gene expression and high Hb F levels in beta-thalassemia and sickle cell anemia patients. Proc Natl Acad Sci U S A. 1985 Apr;82(7):2111–2114. doi: 10.1073/pnas.82.7.2111. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Macklis R. M., Javid J., Lipton J. M., Kudisch M., Pettis P. K., Nathan D. G. Synthesis of hemoglobin F in adult simian erythroid progenitor-derived colonies. J Clin Invest. 1982 Oct;70(4):752–761. doi: 10.1172/JCI110671. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Messing J. New M13 vectors for cloning. Methods Enzymol. 1983;101:20–78. doi: 10.1016/0076-6879(83)01005-8. [DOI] [PubMed] [Google Scholar]
  17. Miller B. A., Olivieri N., Salameh M., Ahmed M., Antognetti G., Huisman T. H., Nathan D. G., Orkin S. H. Molecular analysis of the high-hemoglobin-F phenotype in Saudi Arabian sickle cell anemia. N Engl J Med. 1987 Jan 29;316(5):244–250. doi: 10.1056/NEJM198701293160504. [DOI] [PubMed] [Google Scholar]
  18. Miller B. A., Salameh M., Ahmed M., Wainscoat J., Antognetti G., Orkin S., Weatherall D., Nathan D. G. High fetal hemoglobin production in sickle cell anemia in the eastern province of Saudi Arabia is genetically determined. Blood. 1986 May;67(5):1404–1410. [PubMed] [Google Scholar]
  19. Milner P. F., Leibfarth J. D., Ford J., Barton B. P., Grenett H. E., Garver F. A. Increased HbF in sickle cell anemia is determined by a factor linked to the beta S gene from one parent. Blood. 1984 Jan;63(1):64–72. [PubMed] [Google Scholar]
  20. Nagel R. L., Fabry M. E., Pagnier J., Zohoun I., Wajcman H., Baudin V., Labie D. Hematologically and genetically distinct forms of sickle cell anemia in Africa. The Senegal type and the Benin type. N Engl J Med. 1985 Apr 4;312(14):880–884. doi: 10.1056/NEJM198504043121403. [DOI] [PubMed] [Google Scholar]
  21. Old J. M., Ayyub H., Wood W. G., Clegg J. B., Weatherall D. J. Linkage analysis of nondeletion hereditary persistence of fetal hemoglobin. Science. 1982 Feb 19;215(4535):981–982. doi: 10.1126/science.6186021. [DOI] [PubMed] [Google Scholar]
  22. Pagnier J., Mears J. G., Dunda-Belkhodja O., Schaefer-Rego K. E., Beldjord C., Nagel R. L., Labie D. Evidence for the multicentric origin of the sickle cell hemoglobin gene in Africa. Proc Natl Acad Sci U S A. 1984 Mar;81(6):1771–1773. doi: 10.1073/pnas.81.6.1771. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Papayannopoulou T., Nakamoto B., Buckley J., Kurachi S., Nute P. E., Stamatoyannopoulos G. Erythroid progenitors circulating in the blood of adult individuals produce fetal hemoglobin in culture. Science. 1978 Mar 24;199(4335):1349–1350. doi: 10.1126/science.628844. [DOI] [PubMed] [Google Scholar]
  24. Pembrey M. E., Wood W. G., Weatherall D. J., Perrine R. P. Fetal haemoglobin production and the sickle gene in the oases of Eastern Saudi Arabia. Br J Haematol. 1978 Nov;40(3):415–429. doi: 10.1111/j.1365-2141.1978.tb05813.x. [DOI] [PubMed] [Google Scholar]
  25. Perrine R. P., Brown M. J., Clegg J. B., Weatherall D. J., May A. Benign sickle-cell anaemia. Lancet. 1972 Dec 2;2(7788):1163–1167. doi: 10.1016/s0140-6736(72)92592-5. [DOI] [PubMed] [Google Scholar]
  26. Sanger F., Nicklen S., Coulson A. R. DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463–5467. doi: 10.1073/pnas.74.12.5463. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Shen S. H., Slightom J. L., Smithies O. A history of the human fetal globin gene duplication. Cell. 1981 Oct;26(2 Pt 2):191–203. doi: 10.1016/0092-8674(81)90302-0. [DOI] [PubMed] [Google Scholar]
  28. Wainscoat J. S., Thein S. L., Higgs D. R., Bell J. I., Weatherall D. J., Al-Awamy B. H., Serjeant G. R. A genetic marker for elevated levels of haemoglobin F in homozygous sickle cell disease? Br J Haematol. 1985 Jun;60(2):261–268. doi: 10.1111/j.1365-2141.1985.tb07412.x. [DOI] [PubMed] [Google Scholar]
  29. Wood W. G., Pembrey M. E., Serjeant G. R., Perrine R. P., Weatherall D. J. Hb F synthesis in sickle cell anaemia: a comparison of Saudi Arab cases with those of African origin. Br J Haematol. 1980 Jul;45(3):431–445. doi: 10.1111/j.1365-2141.1980.tb07163.x. [DOI] [PubMed] [Google Scholar]
  30. Wrightstone R. N., Huisman T. H. On the levels of hemoglobins F and A2 in sickle-cell anemia and some related disorders. Am J Clin Pathol. 1974 Mar;61(3):375–381. doi: 10.1093/ajcp/61.3.375. [DOI] [PubMed] [Google Scholar]
  31. Zeng Y. T., Huang S. Z., Chen B., Liang Y. C., Chang Z. M., Harano T., Huisman T. H. Hereditary persistence of fetal hemoglobin or (delta beta)o-thalassemia: three types observed in South-Chinese families. Blood. 1985 Dec;66(6):1430–1435. [PubMed] [Google Scholar]

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